A5029820057- Hematopoietic Stem Cell Transplantation
- Chronic Myeloid Leukemia Treatments
- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Chronic Lymphocytic Leukemia Research
- CAR-T cell therapy research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Glycosylation and Glycoproteins Research
- Cellular transport and secretion
- Immune Cell Function and Interaction
- Multiple Myeloma Research and Treatments
- T-cell and B-cell Immunology
- Neutropenia and Cancer Infections
- Sphingolipid Metabolism and Signaling
- Antifungal resistance and susceptibility
- Lysosomal Storage Disorders Research
- Fungal Infections and Studies
- Histone Deacetylase Inhibitors Research
- Angiogenesis and VEGF in Cancer
- Eosinophilic Disorders and Syndromes
- Mesenchymal stem cell research
- Bone Tissue Engineering Materials
- Lymphoma Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Cytomegalovirus and herpesvirus research
University of Brescia
2016-2025
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
2016-2025
University of Florence
2024
Gruppo Italiano per il Trapianto di Midollo Osseo
2023
National Research Council
2012-2022
Institute for Experimental Endocrinology and Oncology
2022
Institute of Cell Biology and Neurobiology
2019-2021
Center for Excellence in Molecular Cell Science
2019
National Academies of Sciences, Engineering, and Medicine
2019
Institute of Protein Biochemistry
2011-2018
Chronic graft-versus-host disease (GVHD) is the leading cause of later illness and death after allogeneic hematopoietic stem-cell transplantation. We hypothesized that inclusion antihuman T-lymphocyte immune globulin (ATG) in a myeloablative conditioning regimen for patients with acute leukemia would result significant reduction chronic GVHD 2 years peripheral-blood transplantation from an HLA-identical sibling.We conducted prospective, multicenter, open-label, randomized phase 3 study ATG...
Purpose To compare the outcome of patients with Hodgkin lymphoma who received post-transplantation cyclophosphamide-based haploidentical (HAPLO) allogeneic hematopoietic cell transplantation conventional HLA-matched sibling donor (SIB) and unrelated (MUD). Patients Methods We retrospectively evaluated 709 adult were registered in European Society for Blood Marrow Transplantation database HAPLO (n = 98), SIB 338), or MUD 273) transplantation. Results Median follow-up survivors was 29 months....
A 27-year-old man presented with acute nonlymphocytic leukemia (French–American–British Classification M2) in December 1988 and was induced into complete remission daunorubicin arabinosyl cytosine. In April 1989, he underwent successful bone marrow transplantation (BMT) from his human leukocyte antigen identical sister. One month after BMT, the patient developed a grade I cutaneous graft versus host disease (GVHD). By fourth month, moderate extensive chronic GVHD persistent palmar erythema,...
// Manuela Terranova-Barberio 1 , Maria Serena Roca Andrea Ilaria Zotti Alessandra Leone Francesca Bruzzese Carlo Vitagliano Giosuè Scogliamiglio 2 Domenico Russo 3 Giovanni D'Angelo Renato Franco Alfredo Budillon Elena Di Gennaro Experimental Pharmacology Unit, Istituto Nazionale Tumori Fondazione G. Pascale - IRCCS, Naples, Italy Pathology Institute of Protein Biochemistry, National Research Council, Correspondence to: Budillon, e-mail: a.budillon@istitutotumori.na.it Keywords: HDAC...
Abstract Circulating endothelial cells (CEC) represent a restricted peripheral blood (PB) cell subpopulation with high potential diagnostic value in many endothelium-involving diseases. However, whereas the interest CEC studies has grown, standardization level of their detection not. Here, we undertook task to align phenotypes and counts, by standardizing novel flow cytometry approach, within network six laboratories. were identified as alive/nucleated/CD45negative/CD34bright/CD146positive...
Article13 September 2021Open Access Source DataTransparent process GRASP55 regulates intra-Golgi localization of glycosylation enzymes to control glycosphingolipid biosynthesis Prathyush Pothukuchi orcid.org/0000-0002-6242-2319 Institute Biochemistry and Cell Biology, National Research Council Italy, Rome, Italy Search for more papers by this author Ilenia Agliarulo These authors contributed equally work Marinella Pirozzi Riccardo Rizzo Domenico Russo Gabriele Turacchio Julian Nüchel...
Motivated by the enormous potential of hydrogels in regenerative medicine, new biocompatible gelatin-based hybrid were developed through a green process using poly(ethylene glycol) diglycidyl ether as cross-linking agent, adding carrageenan and chitosan polysaccharides to network better mimic composition native extracellular matrix. Overall, show suitable structural stability, high porosity pore interconnectivity, good swellability, finally, biocompatibility. Their mechanical behavior,...
Abstract Purpose: Resveratrol (3,4',5-tri-hydroxy-trans-stilbene) is an antioxidant constituent of a wide variety plant species including grapes. It has gained considerable attention because its anticancer properties, as shown in solid and hematologic malignancies. Whether resveratrol could inhibit proliferation or induce cytotoxicity Waldenström's macroglobulinemia (WM) was investigated. Experimental Design: We studied resveratrol-induced inhibition induction WM cell lines, primary tumor...
A human bone marrow-derived mesenchymal stromal cell (MSCs) and cord blood-derived CD34+ stem co-culture system was set up in order to evaluate the proliferative differentiative effects induced by MSCs on cells, reciprocal influences gene expression profiles. After 10 days of co-culture, non-adherent (SN-fraction) adherent (AD-fraction) cells were collected analysed separately. In presence MSCs, a significant increase number observed (fold = 14.68), mostly SN-fraction 13.20). This combined...
Late relapse of acute myeloid leukemia (AML) is the main reason for treatment failure after a successful allogeneic hematopoietic stem cell transplant (allo-HSCT). A rare manifestation disease reoccurrence isolated sarcoma. 67-year-old gentleman underwent allo-HSCT in 2020 achieving second complete remission, following salvage relapsed AML originally diagnosed 2018. At onset, cytogenetic assay on bone marrow was remarkable translocation (16;17)(p11;p13); retrospective next-generation...
Background The hepatic Veno-Occlusive Disease (VOD), also known as Sinusoidal Obstruction Syndrome (SOS), is a serious complication that can occur after high-dose chemotherapy and hematopoietic stem cell transplantation (HSCT). In Italy, the approach to VOD varies due differences in healthcare practices diagnostic criteria among different regions. Aim methods To address this issue, structured, multi-step Delphi consensus project was undertaken with aim of standardizing therapeutic pathways...
'Non-classical' Myeloproliferative Neoplasms (MPNs) and Myelodysplastic/Myeloproliferative (MDS/MPNs) represent a heterogeneous group of malignancies characterized by wide range clinical manifestations. Unlike classical MPNs, there is no standardized management approach for these conditions, particularly concerning the indications allogeneic hematopoietic cell transplantation (HCT). To address this gap, EBMT Practice Harmonization Guidelines (PH&G) Committee Chronic Malignancies Working...
Background: Acute myeloid leukemia (AML) primarily affects older adults and is associated with poor prognosis, particularly in patients aged ≥ 60 years comorbidities adverse disease characteristics. Standard intensive chemotherapy, such as the “7 + 3” regimen, has shown limited efficacy substantial toxicity this population, underscoring need for alternative treatment strategies. In recent years, venetoclax-based regimens have emerged an important option, demonstrating promising outcomes...