A5079770116- Chronic Lymphocytic Leukemia Research
- Multiple Myeloma Research and Treatments
- Lymphoma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Hematopoietic Stem Cell Transplantation
- Chronic Myeloid Leukemia Treatments
- Viral-associated cancers and disorders
- Cancer Treatment and Pharmacology
- Acute Lymphoblastic Leukemia research
- CAR-T cell therapy research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cytomegalovirus and herpesvirus research
- Immune Cell Function and Interaction
- T-cell and Retrovirus Studies
- Retinoids in leukemia and cellular processes
- Antifungal resistance and susceptibility
- Monoclonal and Polyclonal Antibodies Research
- Cutaneous lymphoproliferative disorders research
- Immunodeficiency and Autoimmune Disorders
- HIV/AIDS drug development and treatment
- Cancer therapeutics and mechanisms
- Eosinophilic Disorders and Syndromes
- T-cell and B-cell Immunology
- RNA Research and Splicing
- Protein Degradation and Inhibitors
Azienda Ospedaliero-Universitaria di Modena
2013-2023
University of Modena and Reggio Emilia
2012-2021
Fondazione Gimema Onlus
2007-2020
Azienda Sanitaria Ospedaliera S.Croce e Carle Cuneo
2015
University of Milan
2004-2011
Ospedale Maggiore
2010
Heinrich Heine University Düsseldorf
2010
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2010
Duran i Reynals Hospital
2010
Istituto di Ematologia di Bologna
2007
Chronic graft-versus-host disease (GVHD) is the leading cause of later illness and death after allogeneic hematopoietic stem-cell transplantation. We hypothesized that inclusion antihuman T-lymphocyte immune globulin (ATG) in a myeloablative conditioning regimen for patients with acute leukemia would result significant reduction chronic GVHD 2 years peripheral-blood transplantation from an HLA-identical sibling.We conducted prospective, multicenter, open-label, randomized phase 3 study ATG...
We performed a prospective, randomized study of single (arm A) versus double B) autologous stem-cell transplantation (ASCT) for younger patients with newly diagnosed multiple myeloma (MM).A total 321 were enrolled onto the and randomly assigned to receive either course high-dose melphalan at 200 mg/m2 or followed, after 3 6 months, by 120 busulfan 12 mg/kilogram B).As compared assignment single-transplantation group (n = 163 patients), random ASCT 158 patients) significantly increased...
Purpose Peripheral T-cell lymphomas (PTCLs) are a heterogeneous group of malignancies characterized by poor prognosis. We performed pilot study to investigate the role reduced-intensity conditioning (RIC) followed allogeneic stem-cell transplantation in relapsed or refractory PTCLs. Patients and Methods have conducted phase II trial on 17 patients receiving salvage chemotherapy RIC hematopoietic cells. The regimen consisted thiotepa, fludarabine, cyclophosphamide. acute graft-versus-host...
Human herpesvirus 8 (HHV-8) infection has been linked to the development of Kaposi's sarcoma and rare lymphoproliferative disorders.
To analyze the outcome of allogeneic transplantation for mycosis fungoides and Sézary syndrome (MF/SS) in terms nonrelapse mortality (NRM), relapse/progression (REL), progression-free survival (PFS), overall (OS) to identify factors associated with outcome.Sixty patients MF (n = 36) SS 24) who received a first hematopoietic cell (HCT) from matched related (mRD; n 45) or unrelated donor (mUD; 15) between 1997 2007 were registered European Group Blood Marrow Transplantation database analyzed:...
Results of allogeneic stem-cell transplantation (allo) in myeloma are controversial. In this trial autologous (auto) followed by reduced-intensity conditioning matched sibling donor allo (auto-allo) was compared with auto only previously untreated multiple myeloma.In all, 357 patients up to age 69 years were enrolled from 2001 2005. Patients an HLA-identical allocated the auto-allo arm (n = 108) and without a 249). Single 145) or tandem 104) optional. Conditioning for melphalan 200 mg/m(2);...
Macrophages reside in tissues infiltrated by chronic lymphocytic leukemia B cells and the extent of infiltration is associated with adverse prognostic factors. We studied blood monocyte population flow cytometry whole-genome microarrays. A mixed lymphocyte reaction was performed to evaluate proliferation T contact monocytes from patients normal donors. Migration gene modulation cultured CLL were also evaluated. The absolute number increased compared controls (792±86 cells/μL versus 485±46...
Several studies in mouse model of invasive aspergillosis (IA) and healthy donors have shown that different Aspergillus antigens may stimulate adaptive immune responses. However, the occurrence Aspergillus-specific T cells not yet been reported patients with disease. In IA, we investigated during infection: a) whether how specific T-cell responses to occur develop; b) which elicit highest frequencies protective and, c) such could be expanded ex-vivo. Forty hematologic studied, including 22 IA...
ABSTRACT We report on the first detection of NDM-1 carbapenemase in Italy, Escherichia coli isolated October 2009. Prolonged colonization and relapsing infection by NDM-1-positive E. were observed a patient (index case) with an indirect epidemiological link areas endemicity. Transient was apparently another linked index case.