A5019049908- Medical Imaging Techniques and Applications
- Radiation Detection and Scintillator Technologies
- Nuclear Physics and Applications
- Atomic and Subatomic Physics Research
- Advanced X-ray and CT Imaging
- Advanced Radiotherapy Techniques
- Digital Radiography and Breast Imaging
- Educational and Social Studies
- Radiopharmaceutical Chemistry and Applications
- Particle Detector Development and Performance
- Radiomics and Machine Learning in Medical Imaging
- Radiation Therapy and Dosimetry
- Infrared Target Detection Methodologies
- Advanced Semiconductor Detectors and Materials
- Advanced MRI Techniques and Applications
- Radiation Dose and Imaging
- Nanoplatforms for cancer theranostics
- Consumer Retail Behavior Studies
- Luminescence Properties of Advanced Materials
- Photoacoustic and Ultrasonic Imaging
- Prostate Cancer Treatment and Research
- Diverse academic and cultural studies
- Italian Social Issues and Migration
- Nanoparticle-Based Drug Delivery
- X-ray Spectroscopy and Fluorescence Analysis
Sapienza University of Rome
2016-2025
National Agency for New Technologies, Energy and Sustainable Economic Development
2009-2024
Universidad Latina
2020
Istituto Nazionale di Fisica Nucleare, Sezione di Roma I
2005-2018
Institut de l'Information Scientifique et Technique
2018
Istituto Nazionale di Fisica Nucleare
2008-2015
University of Bologna
2005-2009
Istituto Nazionale di Fisica Nucleare, Roma Tor Vergata
2009
Istituto Nazionale di Fisica Nucleare, Sezione di Bologna
2009
Istituto Nazionale di Fisica Nucleare, Sezione di Padova
2009
Aim: To realize and characterize a new generation of keratin-coated gold nanoparticles (Ker-AuNPs) as highly efficient photosensitive nanosized therapeutics for plasmonic photothermal (PPT) therapy. Materials & methods: The chemical, physical, morphological properties Ker-AuNPs are investigated using dynamic light scattering, ζ-potential, UV-Visible, Fourier transform infrared spectroscopy, x-ray photoelectron transmission electron microscopy high-resolution thermography. In vitro...
Biocompatible gold nanoparticles (AuNPs) are particularly interesting for photo-thermal therapy (PTT) of cancer treatment because their ability to convert light into heating efficiently. Nevertheless, the random accumulation AuNPs in tissues, mainly determined by retention time bloodstream, is one main limiting factors use PTT applications. For this reason, efficient targeting and monitoring selected tissues paramount importance. This manuscript reports on a new generation 99mTc-labeled...
PET/CT has recently been shown to be a viable alternative traditional post-infusion imaging methods providing good quality images of 90Y-laden microspheres after selective internal radiation therapy (SIRT). In the present paper, first we assessed quantitative accuracy 90Y-PET using an anthropomorphic phantom provided with lungs, liver, spine, and cylindrical homemade lesion located into hepatic compartment. Then, explored different computational approaches on dose calculation, including (I)...
The present paper introduces the so-called scintillator footprints, consisting of plots showing XRF-escape peaks and their relative emission intensities in energy range interest for nuclear medicine SPECT PET. A footprint describes suitability a quantitative investigation with best possible detectability. Sixteen scintillation materials have been identified literature, characterized by effective atomic numbers Zeff ranging between 22 75. footprints NaI:Tl BGO, confirm spectral analysis PET,...
Gamma ray imaging is usually accomplished by the use of a relatively large scintillating crystal coupled to either number photomultipliers (PMTs) (Anger Camera) or single Position Sensitive PMT (PSPMT). Recently development new diagnostic techniques, such as scintimammography and radio-guided surgery, have highlighted significant limitations Anger camera in procedures. In this paper dedicated gamma proposed for clinical applications with aim improving image quality utilizing detectors an...
Before entering human clinical studies to evaluate their safety and effectiveness, new drugs novel medical treatments are subject extensive animal testing that expensive time-consuming. By contrast, advanced technologies enable the development of animal-free models allow efficacy innovative therapies be studied without sacrificing animals, while providing helpful information details. We report on powerful combination 3D bioprinting (3DB) photo-thermal therapy (PTT) applications. To this end,...
A method is introduced for the evaluation of x-ray spectra from machines operating in range 50-100 kVp using a cadmium telluride (CdTe) detector with low detection efficiency. The pulse height distribution obtained this kind does not represent true photon owing to presence K-escape, Compton scattering, etc.; these effects were evaluated Monte Carlo method. stripping procedure described implementation on Univac 1100/82 computer. validity our was finally tested by comparison experimental...
The proposal of Mindview European Project concerns with the development a very high resolution and efficiency brain dedicated PET scanner simultaneously working Magnetic Resonance scanner, that expects to visualize neurotransmitter pathways their disruptions in quest better diagnose schizophrenia. On behalf this project, we propose low cost module for first prototype, based on monolithic crystals, suitable be integrated head Radio Frequency (RF) coil. aim suggested is achieve performances...
The main diagnostic tools for primary and metastatic central nervous system (CNS) tumors are the anamnestic neurological examination imaging tests, which expensive lack specificity. In recent years, shell of macromolecules forms on nanoparticles (NPs) when they exposed to human blood, also known as hard corona (HC), became a powerful tool in diagnostics. Indeed, HC can act “nano-concentrator” serum proteins detect minor changes protein concentration at very early stages disease development....
A new scintillation detector system has been designed for application in high resolution positron emission tomography (PET). The is a bundle of small YAlO/sub 3/:Ce (YAP) crystals closely packed (0.2/spl times/0.2/spl times/3.0 cm/sup 3/), coupled to position sensitive photomultiplier tube (PSPMT). preliminary results obtained spatial resolution, time energy and efficiency 2 such detectors working coincidence are presented. These 1.2 mm the FWHM 2.0 ns 20% at 511 keV. measured (44/spl...
The authors report on the performance of two small field view, compact gamma cameras working in single photon counting planar imaging tests at 122 and 140 keV. first camera is based a scintillator continuous crystal assembled with flat panel multianode photomultiplier tube parallel readout. second one belongs to class semiconductor hybrid pixel detectors, specifically, CdTe detector square pixels pitch , read out by CMOS integrated circuit Medipix2 series. scintillation was operated...
Nuclear medicine imaging devices commonly use multi-element photo detection systems, composed of an array N × elements, each one providing individual signal. Many strategies have been developed to reduce the number readout channels, main approaches is Rows and Columns (R/C) projection logic. In this paper we proposed a modified version Raised To Power (RTP) algorithm adapted R/C order validate its efficiency linear scanning irradiation on two 49× 49 mm2 LaBr3:Ce (0.5%) crystals with...
Abstract We present the first results of MINDVIEW project. An innovative imaging system for human brain examination, allowing simultaneous acquisition PET/MRI images, has been designed and constructed. It consists a high sensitivity resolution PET scanner integrated in novel, head-dedicated, radio frequency coil 3T MRI scanner. Preliminary measurements from show 3 times higher than state-of-the-art systems that will allow safe repeated studies on same patient. The achieved spatial...
Prone scintimammography with Tc-99m SestaMIBI has been proposed as a method of detecting breast cancers in women dense breasts. Clinical reports have shown that this technique lacks sensitivity for cancer smaller than 1 cm. To overcome some limitations offered by Auger camera on imaging was realized new scintigraphic detector dedicated to SPEM (Single Photon Emission Mammography). This novel small FOV device, shows high spatial resolution performances (<2 mm), but poorer energy values, (17%...