A5063703722- Radiation Detection and Scintillator Technologies
- Medical Imaging Techniques and Applications
- Nuclear Physics and Applications
- Atomic and Subatomic Physics Research
- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- Advanced X-ray and CT Imaging
- Digital Radiography and Breast Imaging
- Particle Detector Development and Performance
- Advanced Semiconductor Detectors and Materials
- Traditional Chinese Medicine Studies
- Photoacoustic and Ultrasonic Imaging
- Image and Signal Denoising Methods
- Luminescence Properties of Advanced Materials
- Advanced Vision and Imaging
- Breast Cancer Treatment Studies
- Cancer Diagnosis and Treatment
- Ultrasound and Hyperthermia Applications
- Medical Image Segmentation Techniques
- Brain Metastases and Treatment
- Advanced Data Compression Techniques
- Optical Systems and Laser Technology
- Fault Detection and Control Systems
- Radiation Dose and Imaging
Sapienza University of Rome
2011-2020
Istituti di Ricovero e Cura a Carattere Scientifico
2018-2020
Istituto Tumori Bari
2017-2020
Università Campus Bio-Medico
2016
Instituto de Instrumentación para Imagen Molecular
2016
The proposal of Mindview European Project concerns with the development a very high resolution and efficiency brain dedicated PET scanner simultaneously working Magnetic Resonance scanner, that expects to visualize neurotransmitter pathways their disruptions in quest better diagnose schizophrenia. On behalf this project, we propose low cost module for first prototype, based on monolithic crystals, suitable be integrated head Radio Frequency (RF) coil. aim suggested is achieve performances...
Nuclear medicine imaging devices commonly use multi-element photo detection systems, composed of an array N × elements, each one providing individual signal. Many strategies have been developed to reduce the number readout channels, main approaches is Rows and Columns (R/C) projection logic. In this paper we proposed a modified version Raised To Power (RTP) algorithm adapted R/C order validate its efficiency linear scanning irradiation on two 49× 49 mm2 LaBr3:Ce (0.5%) crystals with...
The Depth of Interaction (DoI) detection is crucial in many medical imaging applications such as small ring PET and high resolution SPECT. In this work we investigate the possibility to discriminate DoI using continuous crystals. A LaBr <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> (Ce) crystal has been used system for its intrinsic light yield, that especially at low energies (e.g. 140 keV) reduces considerably statistical...
Achieved spatial resolution of the PET systems is often limited by parallax error due to lack information about Depth Interaction (DoI) inside crystal incoming 511 keV annihilation photons. The smaller diameter ring and thicker scintillator are, more this affects imaging performance. In work, a DoI calculator suitable for monolithic scintillation crystals based on shape light distribution at photodetector surface has been proposed. To test estimator performance, module with <inline-formula...
The Multimodal Imaging of Neurological Disorders (MINDview) project aims to develop a high resolution and sensitivity dedicated brain Positron Emission Tomography (PET) system capable visualizing neurotransmitter pathways their disruptions for mental disorders diagnosis treatment follow-up. Moreover, this compact PET should be fully compatible with Magnetic Resonance (MRI) in order allow its operation as insert hybrid imaging setup most MRI scanners. proposed design will enable current...
Before the approval of any Intensity Modulated Radiation Therapy or Volumetric Arc treatment plan, quality assurance (QA) tests are needed to reveal potential errors such as an inaccurate calculation dose distribution, failure record-and-verify system, delivery system linear accelerator. Currently, method adopted compare measured distribution with planning TPS calculated is gamma analysis. However, analysis has been shown be ineffective for clinical evaluation plans. We proposed and tested a...
The Depth of Interaction (DoI) discrimination gamma-photons within scintillation crystals allows to improve imaging performance in PET scanners as well SPECT devices equipped with non-parallel collimators (e. g. pinhole ones). In previous works, the authors experimentally proved efficiency a DoI-encoding technique case 20 mm-thick monolithic crystal module. For thinner commonly used SPECT, DoI determination still remains challenging goal. To this aim, work have evaluated method on 6 LaBr3:Ce...
One of the technical objectives MindView project is developing a brain-dedicated PET insert based on monolithic scintillation crystals. It will be inserted in MRI systems with purpose to obtain simultaneous and brain images. High sensitivity, high image quality performance accurate detection Depth-of-Interaction (DoI) 511keV photons are required. We have developed DoI estimation method, dedicated scintillators, allowing continuous DoI-dependent algorithm for photon planar impact position,...
Over the last thirty years we have been seeing impressive advances in photodetection technology and scintillation crystal production manufacturing. Researchers proposed an variety of small FoV cameras or detector modules for SPET PET. The original position arithmetic based on linear weight is still widely used although this logic generates a conflict between linearity spatial resolution. In paper, propose method floating weights, simply utilizing non amplification anode charge. has tested...
In recent years, a new generation of compact gamma cameras, based on monolithic scintillation crystals, has become increasingly widespread. The main advantages small FoV cameras with respect to the standard ones are high portability, low cost and weight, allowing several clinical applications, from scintimammography intraoperative tumor localization. continuous intrinsic Spatial Resolution (SR) is mainly affected by two factors: light collection efficiency overall crystal thickness. first...
Phoswich detectors based on scintillation crystals are widely diffused for both PET and SPECT applications. In order to separate the signals arising from different layers many methods have been proposed in literature. Separation of commonly relies time discrimination or pulse height discrimination. this work, by means experimental measurement a phoswich detector Lanthanum Bromide Lutetium Fine Silicate monolithic crystals, novel method allowing coming has evaluated. The main feature method,...
A series of small size <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">22</sup> Na point sources have been simulated using GATE, following the NEMA protocol, and applied to geometry a brain dedicated PET so-called MindView. The scanner is currently composed by one ring 20 detector blocks with distance about 330 mm between opposite detectors. Each module includes monolithic LYSO crystal 50 × xmlns:xlink="http://www.w3.org/1999/xlink">3</sup>...
Magnetic Resonance (MR) guided Focused Ultrasound Surgery (MRgFUS) technology, combined with High Intensity (HIFU) beams, has opened to new therapeutic protocols for various pathological conditions. The success of this therapy relies on the accuracy guidance provided by thermal mapping sonication, which is obtained MR imaging. In addition, in recent years, multimodality Positron Emission Tomography and Imaging (PET/MRI) imaging been developed. This technique able provide simultaneous...
GaGG:Ce scintillation crystal is very useful for nuclear imaging purposes, thanks to its several advantages (high density, short decay time, high light yield and good energy resolution, no self-activity, hygroscopic). However, only the recent improvements in growth processes make it available with large size, order use monolithic configuration. The main drawbacks of pixelated crystals, as non-uniform response, production costs optical loss, could be therefore overcome. In this work...
In PET detectors based on monolithic scintillators, the photon impact position can be estimated from light intensity distribution (LD) photodetector pixels. Typically, there is a poor estimation of interaction positions towards edges when linear algorithms such as Center Gravity (CoG) are used. We present novel method to determine coordinates in thick crystals filtering digitized LDs each gamma-event by means an autocorrelation filter and raise power (RTP) positioning algorithm reduce border...
The MindView European Project pursues the development of a high efficiency and resolution brain dedicated PET detector, simultaneously working with Magnetic Resonance Imaging (MRI) system. Since scanner is based on small diameter ring thick monolithic scintillation crystals to assess efficiency, parallax error related off-center positron annihilation critical issue. Depth Interaction (DoI) discrimination can reduce blurring due this phenomenon. In work, we propose novel DoI estimator, ratio...
The localization of radioactivity is an increasing topic interest, both in the field nuclear medicine and for environmental monitoring. We developed a gamma tracker prototype that small handy object can identify direction radioactive source; it consists more than one scintillation detecting elements with cylindrical symmetry (40 mm height 25 large) coupled position sensitive photo matrix SiPM; external crystals (LYSO, attenuation coefficient at 511 keV=0.86 cm <sup...
A proper choice of the scintillation crystal can considerably improve detector performance in nuclear medicine imaging. In this study two promising crystals, CRY018 and CRY019, are characterized terms spectrometric imaging capabilities. Thanks to same irradiation conditions, it has been possible compare their for a wide range energies (30 keV 662 keV) . They have high energy resolution (6.5% 7.6% at respectively), negligible light yield non-proportionality, good position linearity, intrinsic...