A5033637751- Medical Imaging Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- Hepatocellular Carcinoma Treatment and Prognosis
- Neuroendocrine Tumor Research Advances
- Prostate Cancer Treatment and Research
- Lung Cancer Research Studies
- Neuroblastoma Research and Treatments
- Advanced Radiotherapy Techniques
- Lymphoma Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- Cancer Immunotherapy and Biomarkers
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer, Hypoxia, and Metabolism
- Lung Cancer Treatments and Mutations
- Sarcoma Diagnosis and Treatment
- Cardiac tumors and thrombi
- Radiomics and Machine Learning in Medical Imaging
- Cancer, Lipids, and Metabolism
- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Nonmelanoma Skin Cancer Studies
- Bone health and treatments
- Renal cell carcinoma treatment
- Immunotherapy and Immune Responses
- Melanoma and MAPK Pathways
Ospedale Santa Maria Goretti
2015-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2022
Sapienza University of Rome
2011-2022
Istituto Neurologico Mediterraneo
2022
Inform (Germany)
2022
Abstract Purpose A multidisciplinary expert panel convened to formulate state-of-the-art recommendations for optimisation of selective internal radiation therapy (SIRT) with yttrium-90 ( 90 Y)-resin microspheres. Methods steering committee 23 international experts representing all participating specialties formulated SIRT Y-resin microspheres activity prescription and post-treatment dosimetry, based on literature searches the responses a 61-question survey that was completed by 43 leading...
Objectives The decay of 90Y has a minor branch to the O+ first excited state 89Zr, de-excitation which fundamental is followed by β+–β− emission that been used recently for biodistribution assessment after selective internal radiotherapy (SIRT) treatments. purpose present study demonstrate feasibility PET imaging dose radioembolization with microspheres. Methods Activity quantification was validated through preliminary phantom studies using cylindrical body composed six inserts different...
White blood cell (WBC) scintigraphy is considered the nuclear medicine imaging gold standard for diagnosing osteomyelitis in diabetic foot. Recent papers have suggested that use of (18)F-FDG PET/CT produces similar diagnostic accuracy, but clear interpretation criteria not yet been established. Our aim was to evaluate role sequential patients with a high suspicion define objective be compared WBC scintigraphy.Thirteen whom clinicians positive (7 ulcers, 6 exposed bone) were enrolled. The...
PURPOSE The role of consolidation radiotherapy in patients with primary mediastinal B-cell lymphoma (PMBCL) is controversial. METHODS IELSG37 trial, a randomized noninferiority study, aimed to assess whether irradiation can be omitted PMBCL complete metabolic response (CMR) after induction immunochemotherapy. end point was progression-free survival (PFS) at 30 months random assignment. Patients CMR were randomly assigned observation or (30 Gy). With margin 10% (assuming 30-month PFS 85% both...
PET/CT has recently been shown to be a viable alternative traditional post-infusion imaging methods providing good quality images of 90Y-laden microspheres after selective internal radiation therapy (SIRT). In the present paper, first we assessed quantitative accuracy 90Y-PET using an anthropomorphic phantom provided with lungs, liver, spine, and cylindrical homemade lesion located into hepatic compartment. Then, explored different computational approaches on dose calculation, including (I)...
To demonstrate the feasibility of 90Y-PET imaging for biodistribution assessment after selective internal radiotherapy treatments with 90Y-microspheres, comparing results 99mTc-macroaggregated albumin (MAA) images obtained single-photon emission computed tomography.Preliminary studies were performed aim evaluating system spatial resolution and scanner sensitivity detecting annihilation photons. Subsequently, microsphere distribution was evaluated in 10 patients who underwent liver treatment....
Objective The aim of this study was to investigate the prognostic value neutrophil-to-lymphocyte ratio (NLR) and its relationship with several metabolic parameters obtained through PET in intrahepatic cholangiocarcinoma (ICC) submitted radioembolization 90 Y-microspheres ( Y-radioembolization). Methods Records 20 subjects affected by ICC Y-radioembolization were retrospectively evaluated. In all cases, pretreatment NLR carried out fluorine-18-fluorodeoxyglucose 18 F-FDG) PET/CT acquired...
We assessed the role of digital PET/CT (dPET/CT) with 18F-FACBC in patients affected by castration-resistant prostate cancer PSA levels ≤ 3 ng/mL (early CRPC), no lesions detectable at cross-sectional imaging (CIM) and bone scan (BS).Clinical data submitted to dPET/CT were retrospectively reviewed. results analyzed: lesions' number, location, and, case positive lymph nodes, largest node's short axis (i.e. SA) annotated. According PET/CT's results, 18F-FACBC-avid further stratified into 1)...
This recommendation by the Italian Associations of Nuclear Medicine (AIMN) and Medical Physics (AIFM) focuses on dosimetric optimization Therapy (NMT) as clearly requested article 56 EURATOM Directive 2013/59 its consequent implementation in 158 Law n. 101/2020. However, this statement must deal with scientific methodological limits that still exist and, above all, currently available limited resources. paper addresses these specific issues. It distinguishes among many possible kinds NMT....