Michele Larobina

ORCID: 0000-0002-4093-046X
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About
Contact & Profiles
Research Areas
  • Medical Imaging Techniques and Applications
  • Digital Radiography and Breast Imaging
  • Spectroscopy Techniques in Biomedical and Chemical Research
  • Radiomics and Machine Learning in Medical Imaging
  • Medical Image Segmentation Techniques
  • Spectroscopy and Chemometric Analyses
  • Advanced MRI Techniques and Applications
  • Cardiovascular Function and Risk Factors
  • Radiation Detection and Scintillator Technologies
  • Cardiac Imaging and Diagnostics
  • Brain Tumor Detection and Classification
  • Ultrasound Imaging and Elastography
  • Multiple Sclerosis Research Studies
  • Functional Brain Connectivity Studies
  • Advanced Neuroimaging Techniques and Applications
  • MRI in cancer diagnosis
  • Advanced Fluorescence Microscopy Techniques
  • Particle Detector Development and Performance
  • Nuclear Physics and Applications
  • Advanced X-ray and CT Imaging
  • Ultrasound and Hyperthermia Applications
  • AI in cancer detection
  • Immunotherapy and Immune Responses
  • Peptidase Inhibition and Analysis
  • Metabolomics and Mass Spectrometry Studies

Institute of Biostructure and Bioimaging
2006-2023

National Research Council
2011-2021

University of Naples Federico II
1999-2016

Consorzio Roma Ricerche
2013

National Academies of Sciences, Engineering, and Medicine
2010-2012

Federico II University Hospital
1998-2003

Istituto Nazionale di Fisica Nucleare, Sezione di Napoli
1993-1994

Presidenza Del Consiglio Dei Ministri
1994

<sup>18</sup>F-FDG PET/CT allows the direct measurement of metabolic tumor burden in a variety different malignancies. The aim this study was to assess whether volume (MTV) determined by could be used prediction progression-free and overall survival multiple myeloma patients. <b>Methods:</b> Forty-seven patients (18 women, 29 men; mean age ± SD, 63 11 y) with stage IIIA disease who had undergone whole-body were retrospectively evaluated. Images underwent 3-dimensional region-of-interest...

10.2967/jnumed.112.106500 article EN Journal of Nuclear Medicine 2012-10-15

A fully automated magnetic resonance (MR) segmentation method for identification and volume measurement of demyelinated white matter has been developed. Spin-echo MR brain scans were performed in 38 patients with multiple sclerosis (MS) 46 healthy subjects. Segmentation normal tissues lesions (WML) was obtained, based on their relaxation rates proton density maps. For WML identification, additional criteria included three-dimensional (3D) lesion shape surrounding tissue composition....

10.1002/1522-2586(200012)12:6<799::aid-jmri2>3.0.co;2-# article EN Journal of Magnetic Resonance Imaging 2000-11-29

A fully automated magnetic resonance (MR) segmentation method for identification and volume measurement of demyelinated white matter has been developed. Spin-echo MR brain scans were performed in 38 patients with multiple sclerosis (MS) 46 healthy subjects. Segmentation normal tissues lesions (WML) was obtained, based on their relaxation rates proton density maps. For WML identification, additional criteria included three-dimensional (3D) lesion shape surrounding tissue composition....

10.1002/1522-2586(200012)12:6<799::aid-jmri2>3.0.co;2- article EN Journal of Magnetic Resonance Imaging 2000-01-01

At the Department of Physics University Pisa, Italy, a new and fully engineered version YAP-(S)PET small animal scanner has been recently installed. The is able to perform both PET SPECT studies on animals. made up four heads: each one composed 4/spl times/4 cm/sup 2/ YAlO/sub 3/:Ce (or YAP:Ce) matrix 20/spl times/20 elements, 2/spl times/2/spl times/25 mm/sup 3/ each, coupled Position Sensitive Photomultiplier (PS-PMT) (Hamamatsu R2486). modules are positioned rotating gantry. switching...

10.1109/tns.2006.871900 article EN IEEE Transactions on Nuclear Science 2006-06-01

A Riemannian manifold optimization strategy is proposed to facilitate the relaxation of orthonormality constraint in a more natural way course performing independent component analysis (ICA) that employs mutual information-based source-adaptive contrast function. Despite extensive development techniques catering constraint, only limited number works have been dedicated oblique (OB) algorithms intrinsically handle normality which has empirically shown be superior other and Euclidean...

10.1109/tnnls.2012.2218060 article EN IEEE Transactions on Neural Networks and Learning Systems 2012-10-23

This work addresses some key challenges in the fields of bio and nanophotonics by stimulated Raman microscopy.We present design implementation a femtosecond scattering microscope, equipped with three laser sources, which allows coexistence gain (SRG) stimulate losses (SRL) detection modes single microscopy setup to generate images same region succession, without adding or removing components.In order demonstrate switching between two modes, SRL SRG polystyrene beads are acquired quality...

10.1364/oe.26.026317 article EN cc-by Optics Express 2018-09-25

10.1016/j.nima.2015.10.071 article EN Nuclear Instruments and Methods in Physics Research Section A Accelerators Spectrometers Detectors and Associated Equipment 2015-10-26

In 16 patients with probable Alzheimer's disease (AD; NINDS criteria, age range 56–78 years), gray matter (GM), white (WM), and cerebrospinal fluid (CSF) absolute fractional volumes were measured an unsupervised multiparametric post-processing segmentation method based on estimates of relaxation rates R1, R2 (R1 = 1/T1; 1/T2) proton density [N(H)] from conventional spin-echo studies (Alfano et al. Magn. Reson. Med. 1997;37:84–93). Global brain atrophy, GM WM fractions significantly...

10.1002/(sici)1522-2586(200003)11:3<260::aid-jmri4>3.0.co;2-i article EN Journal of Magnetic Resonance Imaging 2000-03-01

At the Department of Physics University Pisa, a new and fully engineered version YAP-(S)PET small animal scanner has been recently installed. The is able to perform both PET SPECT studies on animals. made up four heads: each one composed 4times4 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> YAlO <sub xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> :Ce (or YAP:Ce) matrix 20times20 elements, 2times2times25 mm...

10.1109/nssmic.2004.1466313 article EN IEEE Symposium Conference Record Nuclear Science 2004. 2005-08-10

Double-sided microstrip silicon crystals are tested as detectors for X-rays in the diagnostic energy range (10-100 keV) digital radiography. An analog-to-digital converter (ADC) and CAMAC-based acquisition system is developed to study imaging capabilities of a mu strip detector with 100- 200- m read-out pitch. The first images submillimeter high contrast phantoms obtained an X-ray mammography tube operating at flux density presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML"...

10.1109/23.256698 article EN IEEE Transactions on Nuclear Science 1993-08-01
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