A5007493200- Multiple Sclerosis Research Studies
- Liver Disease Diagnosis and Treatment
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Functional Brain Connectivity Studies
- Medical Imaging Techniques and Applications
- Biochemical Analysis and Sensing Techniques
- Systemic Lupus Erythematosus Research
- Eating Disorders and Behaviors
- Diet, Metabolism, and Disease
- Schizophrenia research and treatment
- Olfactory and Sensory Function Studies
- Peripheral Neuropathies and Disorders
- Hepatocellular Carcinoma Treatment and Prognosis
- Retinal Development and Disorders
- Ultrasound Imaging and Elastography
- Radiomics and Machine Learning in Medical Imaging
- Atomic and Subatomic Physics Research
- Diet and metabolism studies
- Systemic Sclerosis and Related Diseases
- MRI in cancer diagnosis
- Rheumatoid Arthritis Research and Therapies
- Retinal Imaging and Analysis
- Obsessive-Compulsive Spectrum Disorders
- Medical Image Segmentation Techniques
Institute of Biostructure and Bioimaging
2015-2024
National Research Council
2015-2024
Istituti di Ricovero e Cura a Carattere Scientifico
1995-2016
SDN Istituto di Ricerca Diagnostica e Nucleare
1995-2016
National Academies of Sciences, Engineering, and Medicine
2007-2016
Federico II University Hospital
2008
Cyceron
2006
Inserm
2006
University of Cambridge
2006
University of Campania "Luigi Vanvitelli"
2005
To evaluate the effects of qualitative dietary changes and interaction with aerobic exercise training on liver fat content independent weight loss in patients type 2 diabetes.With use a factorial × randomized parallel-group design, 37 men 8 women, aged 35-70 years, diabetes satisfactory blood glucose control diet or plus metformin treatment were assigned to one following groups for an 8-week period: 1) high-carbohydrate/high-fiber/low-glycemic index (CHO/fiber group), 2) high-MUFA (MUFA 3)...
Abstract In this study, changes in blood oxygenation and volume were monitored while monolingual right-handed subjects read English sentences. Our results confirm the role of left peri-sylvian cortex language processing. Interestingly, individual subject analyses reveal a pattern activation characterized by several small, limited patches rather than few large, anatomically well-circumscribed centers. Between-subject lateralized active classical areas including Broca's area, Wernicke's...
Background The neurobiological underpinnings of avolition in schizophrenia remain unclear. Most brain imaging research has focused on reward prediction deficit and ventral striatum dysfunction, but findings are not consistent. In the light accumulating evidence that both dorsal caudate play a key role motivation, we investigated activation during processing or loss patients with schizophrenia. Method We used functional magnetic resonance to study Monetary Incentive Delay task schizophrenia,...
Overconsumption of dietary sugars, fructose in particular, is linked to cardiovascular risk factors such as type 2 diabetes, obesity, dyslipidemia and nonalcoholic fatty liver disease. However, clinical studies have date not clarified whether these adverse cardiometabolic effects are induced directly by or they secondary weight gain.To assess the (75 g day-1 ), served with their habitual diet over 12 weeks, on fat content other a large cohort (n = 71) abdominally obese men.We analysed...
To measure white matter (WM) and gray (GM) atrophy lesion load in a large population of patients with multiple sclerosis (MS) using fully automated, operator-independent, multiparametric segmentation method.The study consisted 597 MS 104 control subjects. The MRI parameters were abnormal WM fraction (AWM-f), global WM-f (gWM-f), GM (GM-f).Significant differences between subjects included higher AWM-f reduced gWM-f GM-f. data showed significant relapsing-remitting secondary progressive forms...
A large body of evidence suggests that, besides their cholesterol-lowering effect, statins exert anti-inflammatory action. Consequently, may have therapeutic potential in immune-mediated disorders such as multiple sclerosis. Our objectives were to determine safety, tolerability and efficacy low-dose atorvastatin plus high-dose interferon beta-1a sclerosis patients responding poorly alone. Relapsing—remitting patients, aged 18—50 years, with contrast-enhanced lesions or relapses while on...
Objectives: Childhood maltreatment is a non-specific risk factor for eating disorders (EDs). However, so far, no study has assessed the impact of childhood on brain structure adults with EDs. Therefore, we investigated area volumes and fibre tract integrity maltreated (Mal) non-maltreated (noMal) patients Methods: Thirty-six ED women 16 healthy underwent an MRI scan, including acquisition diffusion tensor imaging (DTI) sequence high-resolution T1-weighted scan. participants were classified...
Previous studies have shown a preferential loss of grey matter in fronto-temporal regions patients with multiple sclerosis. Studies correlates disease severity are more controversial, because some suggested an association between sensorimotor cortex atrophy and Expanded Disability Status Scale score, while others did not find such correlation. The objective this study was to assess the correlation regional white indexes clinical radiological relapsing-remitting sclerosis, including lesion...
Approximately 30% of schizophrenia patients do not respond adequately to the therapy. Previous MRI studies have suggested that drug treatment resistance is associated with brain morphological abnormalities, although region-of-interest analysis MR from nonresponder and responder failed demonstrate a statistically significant difference between these two subgroups. We used voxel-based segmented assess structural cerebral differences in 20 15 16 age-matched normal volunteers. Differences three...
The presence of significant fibrosis is an indicator for liver disease staging and prognosis. aim the study was to determine reproducibility real-time shear wave elastography using a hepatic biopsy as reference standard identify patients with chronic disease. Forty 12 normal subjects received performed by skilled operators. Interoperator studied in 29 patients. Fibrosis evaluated Metavir score. median range values were 6.15 kPa 3.14–16.7 4.49 2.92–7.32 subjects, respectively. With respect...
The avolition/apathy domain of negative symptoms includes motivation- and pleasure-related impairments. In people with schizophrenia, structural functional abnormalities were reported in key regions within the motivational reward system, including ventral-tegmental area (VTA), striatum (especially at level nucleus accumbens, NAcc), orbitofrontal cortex (OFC), as well amygdala (Amy) insular (IC). However, association avoliton-apathy is still controversial. present study, we investigated white...
Background Right insular cortex is involved in taste discrimination, but its functional organization still poorly known. In general, sensory cortices represent the spatial prevalence of relevant features for each modality (visual, auditory, somatosensory) an ordered way across cortical space. Following this analogy, we hypothesized that primary organized similar response to six tastes with known receptorial mechanisms (sweet, bitter, sour, salt, umami, CO2). Design Ten normal subjects were...
Our goal was (a) to test the ability of functional MRI (fMRI) localize hand primary motor cortex in patients with brain neoplasms using a conventional scanner and (b) compare within same subject location morphology activated areas affected hemisphere contralateral ones.Seventeen right-handed frontoparietal intra- extraaxial tumors were studied. Hand performance ranged from normal slight impairment finger dexterity. The fMRI study based on series FLASH images. Two or three contiguous slices...