A5055362865- Genetic and Kidney Cyst Diseases
- Dialysis and Renal Disease Management
- Lysosomal Storage Disorders Research
- Metabolism and Genetic Disorders
- Parathyroid Disorders and Treatments
- Diet and metabolism studies
- Glycogen Storage Diseases and Myoclonus
- Biomedical Research and Pathophysiology
- Neurological and metabolic disorders
- Diabetes Management and Research
- Renal Diseases and Glomerulopathies
- Muscle and Compartmental Disorders
- Heart Failure Treatment and Management
- Cystic Fibrosis Research Advances
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Potassium and Related Disorders
- Botulinum Toxin and Related Neurological Disorders
- Chronic Kidney Disease and Diabetes
- Trypanosoma species research and implications
- Diet, Metabolism, and Disease
- Renal and related cancers
- Electrolyte and hormonal disorders
- Neurological diseases and metabolism
- Antibiotic Use and Resistance
- Diverse Scientific Research Studies
University of Naples Federico II
2016-2025
Federico II University Hospital
2020-2024
University of Milan
2016
Ospedale Papa Giovanni XXIII
2016
Antimicrobial resistance (AMR) is one of the major health issues worldwide. Clinicians should play a central role to fight AMR, and medical training pivotal issue combat it; therefore, assessing levels knowledge, attitudes practices among young doctors essential for future antimicrobial stewardship (AMS) programmes. A nationwide, cross-sectional, multicentre survey was conducted in Italy. descriptive analysis knowledge performed, along with univariate multivariate their determinants....
The history of insulin-induced skin lipohypertrophy (LH) runs parallel to that insulin's 100 years, and an average 47% insulin-treated patients still suffer from it today. metabolic economic effects LH are significant, with hypoglycemia being the most striking. objective study was perform a 52-week follow-up 713 type 2 diabetes (T2DM) detect any differences in occurrence hypoglycemic events (HYPOs) related healthcare costs as well rates injection habits between intensive education...
Data on exercise activities in place, and the interest for developing them Nephrology Services Italy is limited. To address this gap, we carried out cross-sectional study to investigate status of physical activity programs available Italian Centres. Additionally, research priorities topic were examined. We developed a 14-item electronic survey, which consisted multiple-choice questions covering training programs, assessment, barriers practice counselling practices, perceived benefits,...
Atheroembolic kidney disease (AEKD) is an under-recognized cause of failure, secondary to the obstruction renal artery and/or its branches due rupture unstable atherosclerotic plaque in patients treated with surgical and invasive cardiovascular procedures. The embolization cholesterol crystals activates complement triggers inflammatory reaction. Atypical hemolytic uremic syndrome (aHUS) a thrombotic microangiopathy caused by hyperactivation alternative pathway, leading prothrombotic...
Magnesium (Mg2+) is essential for cardiovascular and metabolic health, yet hypomagnesemia common in kidney transplant recipients (KTRs) due to immunosuppressive therapy renal dysfunction. Oral Mg2+ supplementation often ineffective poor absorption side effects. Sodium-glucose cotransporter 2 inhibitors (SGLT2i) have been shown increase serum chronic disease, but their effects KTRs, particularly patients without diabetes, remain unclear. This observational study assessed 63 KTRs treated with...
Hyperkalemia is common in patients treated with renin-angiotensin-aldosterone system inhibitors (RAASis), and it represents the main cause of large gap reported between guideline recommendations real-world practice chronic kidney disease (CKD). We conducted a CKD-population-based restrospective study to determine prevalence CKD RAASis, incidence hyperkalemia proportion RAASi medication change after experiencing incident hyperkalemia. Among 809 analyzed, 556 (68.7%) were prescription was...
Fabry disease (FD), also known as Anderson-Fabry disease, is a hereditary disorder of glycosphingolipid metabolism, caused by deficiency the lysosomal alpha-galactosidase A enzyme. This causes progressive accumulation glycosphingolipids in tissues and organs which represents main pathogenetic mechanism FD. The multisystemic characterized early symptoms late complications (renal, cardiac neurological dysfunction). Fatigue exercise intolerance are common FD patients but specific still to be...
Studies on the durability of an intensive, structured education protocol best insulin injection practice are missing for people with type 2 diabetes mellitus (T2DM). The aim this study was to assess education-based rehabilitation in well-trained subjects from our previous multimedia intervention registered as ISTERP-1 study. A total 158 T2DM group 6-month-long study, all whom had successfully attained lower glucose levels compared baseline daily doses and less frequent severe hypoglycemic...
Abstract Background In Italy, nephrology residency is available in twenty-one schools, each with its own strengths and weaknesses. The present study aimed at exploring the residents’ satisfaction their training programs. Methods Between April 20th May 19th, 2021, a questionnaire on consisting of 49 items was sent to 586 residents 175 recently certified specialists (qualified practice as nephrologists 2019 2020), response rate 81% 51%, respectively. teaching organization contextualized survey...
Polycystic Kidney Diseases (PKDs) consist of a genetically and phenotypically heterogeneous group inherited disorders characterized by numerous renal cysts. PKDs include autosomal dominant ADPKD, recessive ARPKD atypical forms. Here, we analyzed 255 Italian patients using an NGS panel 63 genes, plus Sanger sequencing exon 1 the PKD1 gene MPLA (PKD1, PKD2 PKHD1) analysis. Overall, 167 bore pathogenic/likely pathogenic variants in 5 genes. Four were carriers one variant. A total 24 had VUS...
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a common monogenic disorder characterized by renal cysts and progressive failure. In kidney diseases, adipose tissue undergoes functional changes that have been associated with increased inflammation insulin resistance mediated release of adipokines. Adiponectin involved in various cellular processes, such as energy inflammatory oxidative processes. However, it remains to be determined whether adiponectin the concomitant metabolic...
Abstract Background Although enzyme replacement therapy with agalsidase beta resulted in a variety of clinical benefits, life‐long biweekly intravenous infusion may impact on patients’ quality life. Moreover, regular infusions are time‐consuming: although stepwise shortening duration is allowed up to minimum 1.5 hr, most centers it remains ≥3 and no data exists about the safety tolerability administration at maximum tolerated rate. Methods In this study, we reported our experience rate...
Abstract Background and Aims Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary disease, characterized by development of fluid-filled renal cysts leading to progressive expansion volume, with decline in function up end-stage (ESRD). Octreotide long-acting release (OCT-LAR) a synthetic somatostatin analogue, which has been shown reduce growth slow progression ADPKD patients. Although evidence literature supporting protective effect OCT-LAR against patients both...
Orexin-A is a neuropeptide product of the lateral hypothalamus that acts on two receptors, OX1R and OX2R. The orexinergic system involved in feeding, sleep, pressure regulation. Recently, orexin-A levels have been found to be negatively correlated with renal function. Here, we analyzed as well incidence SNPs hypocretin precursor (HCRT) its HCRTR1 HCRTR2, 64 patients affected by autosomal dominant polycystic kidney disease (ADPKD) bearing truncating mutations PKD1 or PKD2 genes. Twenty-four...
Severe hyperammoniemia denotes a clinical condition associated with high blood ammonia levels and uncertain prognosis. The presentation can vary the age of patient magnitude increase in levels. Persistent hyperammonemia, if not treated rapidly, may cause irreversible neuronal damage. aim therapy should be to normalize Recent experience has provided treatment guidelines that include minimizing endogenous production protein catabolism, restricting nitrogen intake, administering substrates urea...