A5008226608- Renal and related cancers
- Genetic and Kidney Cyst Diseases
- Renal Diseases and Glomerulopathies
- Biomedical Research and Pathophysiology
- Genetic Syndromes and Imprinting
- Diet and metabolism studies
- Amino Acid Enzymes and Metabolism
- Eating Disorders and Behaviors
- Cardiac Valve Diseases and Treatments
- Antibiotic Resistance in Bacteria
- Lipoproteins and Cardiovascular Health
- Bacterial biofilms and quorum sensing
- Vitamin D Research Studies
- Genomics and Rare Diseases
- Calcium signaling and nucleotide metabolism
- Glycosylation and Glycoproteins Research
- Climate Change and Health Impacts
- Cancer, Lipids, and Metabolism
- Diversity and Career in Medicine
- Axon Guidance and Neuronal Signaling
- Vitamin K Research Studies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cardiac, Anesthesia and Surgical Outcomes
- Breast Implant and Reconstruction
- Obsessive-Compulsive Spectrum Disorders
Azienda Ospedaliero-Universitaria di Modena
2019-2024
University of Modena and Reggio Emilia
2016-2023
Fondazione IRCCS Istituto Nazionale dei Tumori
2023
Surrey and Sussex Healthcare NHS Trust
2023
King's College London
2020
San Raffaele University of Rome
2012-2014
University of Milan
2014
University of Pavia
1987
Cystic fibrosis (CF) airways disease represents an example of polymicrobial infection whereby different bacterial species can interact and influence each other. In CF patients Staphylococcus aureus is often the initial pathogen colonizing lungs during childhood, while Pseudomonas aeruginosa predominant isolated in adolescents adults. During chronic infection, P. undergoes adaptation to cope with antimicrobial therapy, host response co-infecting pathogens. However, S. co-exist same niche...
Immunohistopathology is an essential technique in the diagnostic workflow of a kidney biopsy. Deep learning effective tool elaboration medical imaging. We wanted to evaluate role convolutional neural network as support for immunofluorescence reporting.High-magnification (×400) images biopsies performed from year 2001 2018 were collected. The report, adopted at Division Nephrology AOU Policlinico di Modena, describes specimen terms "appearance," "distribution," "location," and "intensity"...
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is the most common hereditary kidney disease. We analysed PKD1 and PKD2, in a large cohort of 440 unrelated Italian patients with ADPKD 203 relatives by direct sequencing MLPA. Molecular detailed phenotypic data have been collected submitted to PKD1/PKD2 LOVD database. This first retrospective study patients, describing 701 variants, 249 (35.5%) already associated 452 (64.5%) novel. According criteria adopted, overall detection rate was...
The mechanisms governing the epidemiology dynamics and success determinants of a specific healthcare-associated methicillin-resistant S. aureus (HA-MRSA) clone in hospital settings are still unclear. Important epidemiological changes have occurred Europe since 2000 that been related to appearance ST22-IV clone. Between 2006 2010, we observed establishment displacing predominant Italian clone, ST228-I, large university hospital. To investigate factors associated with successful spread...
The human sialidase, NEU4, has emerged as a possible regulator of neuronal differentiation and its overexpression been demonstrated to promote the acquisition stem cell-like phenotype in neuroblastoma cells. In this paper, we that glioblastoma cells (GSCs) isolated from multiforme (GBM) cell lines patients' specimens neurospheres are specifically marked by upregulation NEU4; contrast, expression NEU4 is very low non-neurosphere-differentiated GBM We showed silencing miRNA or chemical...
In addition to alterations concerning the expression of oncogenes and onco-suppressors, melanoma is characterized by presence distinctive gangliosides (sialic acid carrying glycosphingolipids). Gangliosides strongly control cell surface dynamics signaling; therefore, it could be assumed that these are linked modifications behavior acquired tumor. On bases, this work investigated correlations between ganglioside metabolism profiles biological features tumor survival patients. Melanoma lines...
Abstract Background Autosomal dominant polycystic kidney disease (ADPKD) is mainly characterised by the development and enlargement of renal cysts that lead to end-stage (ESRD) in adult patients. Other clinical manifestations this pathology include hypertension, haematuria, abdominal pain, cardiovascular system alterations intracranial aneurysms. ADPKD linked mutations either PKD1 or PKD2 codifies polycystin-1 (PC1) polycystin-2 (PC2 TRPP2), respectively. PC1 TRPP2 are membrane proteins...
Digital pathology and artificial intelligence offer new opportunities for automatic histologic scoring. We applied a deep learning approach to IgA nephropathy biopsy images develop an prognostic score, assessed against ground truth (kidney failure) among patients with who were treated over 39 years. noninferiority in comparison the component of currently validated predictive tools. correlated additional features our score identify potential features.Training was performed randomly selected,...
During the last few years it has been shown that an anaplastic T cell lymphoma can develop as a rare and late sequelae of implant-based breast reconstruction. This malignancy was recognized in 2017 by WHO named implant associated large (BIA-ALCL). BIA-ALCL usually presents abundant effusion around implant, thus, addition to cytology smears, its diagnosis also requires immunohistochemistry, cells clonality cytometry. Due increasing attention clinicians, is likely number suspected cases will...
Abstract Background and Aims Autosomal dominant polycystic kidney disease (ADPKD) is the 4th cause of end-stage renal in Western Countries, nevertheless still represents an illness with a significant unmet medical need. In recent years, deregulation glucose metabolism ADPKD has been identified. Data suggest that cystic cells shift their energy from oxidative phosphorylation to aerobic glycolysis. Preclinical experiences show beneficial effects terms size reduction, interstitial fibrosis...
Abstract Aims The climate crisis is scientifically irrefutable and poses a major threat to human life (1,2). Healthcare services face the paradox of managing disease burden caused by planetary crisis, whilst simultaneously contributing problem (3, 4). As surgeons, we have duty protect our patients as such decrease environmental impact: this checklist aims provide guidance towards more sustainable surgical practises. Methods A team doctors used evidence-based research, grey literature expert...
Despite disproportionate mortality rates for Black skin cancer patients, medical education and practice guidelines center White bodies fair skin. How did dark become such a deadly dermatological blind spot?