A5036341851- Renal Diseases and Glomerulopathies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Vasculitis and related conditions
- Dialysis and Renal Disease Management
- Renal Transplantation Outcomes and Treatments
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Nutrition and Health in Aging
- Urticaria and Related Conditions
- Infectious Encephalopathies and Encephalitis
- Parathyroid Disorders and Treatments
- Renal and Vascular Pathologies
- Metabolism and Genetic Disorders
- Hepatitis B Virus Studies
- Prion Diseases and Protein Misfolding
- Chronic Kidney Disease and Diabetes
- Muscle and Compartmental Disorders
- Pregnancy and Medication Impact
- Autoimmune Bullous Skin Diseases
- Pediatric Urology and Nephrology Studies
- Inflammasome and immune disorders
- Renal function and acid-base balance
- Body Composition Measurement Techniques
- Genetic and Kidney Cyst Diseases
- Gout, Hyperuricemia, Uric Acid
Azienda Ospedaliera di Perugia
1992-2024
Società Italiana di Nefrologia
2021
University of Perugia
1994-2017
Ospedale Santa Maria
2016
Misericordia University
2012
Nini Hospital
1999
Presidio Ospedaliero
1993
Few data are available from large population-based studies on survival and renal outcome of patients with involvement different types systemic amyloidosis.Two hundred ninety over 373 affected amyloidosis diagnosed in Italy between January 1995 December 2000 were followed diagnosis to death or until the last clinical control. Eighty-three excluded analysis either because amyloid type remained undetermined they lost at follow-up. Clinical laboratory information was collected according using a...
PTPN22 is involved in T-cell activation and its R620W single-nucleotide polymorphism (SNP) has been shown to predispose different autoimmune diseases. The aims of this study were investigate the role SNP conferring susceptibility ANCA-associated vasculitides (AAVs), explore potential associations between genotype disease manifestations.PTPN22 was genotyped a cohort 344 AAV patients [143 with granulomatosis polyangiitis (Wegener's) (GPA), 102 microscopic (MPA) 99 Churg-Strauss syndrome (CSS)]...
ABSTRACT Background The known risks and benefits of native kidney biopsies are mainly based on the findings retrospective studies. aim this multicentre prospective study was to evaluate safety percutaneous renal quantify biopsy-related complication rates in Italy. Methods examined results performed 54 Italian nephrology centres between 2012 2020. primary outcome rate major complications 1 day after procedure, or for longer if it necessary evolution a complication. Centre patient risk...
Hyperuricemia is present in about 5% of the population, and allopurinol frequently used to treat it. The use this drug can be associated with a number side effects, indicating allergic reactions, such as skin rash, reversible after its withdrawal. In some cases more severe hypersensitivity reactions may seen, erythema multiforme exudativum, or Steven-Johnson Syndrome (SJS). Reversible clinical hepatotoxicity, well acute renal failure, also develop therapy. We describe here case 74-year-old...
The epidemiology of non-A, non-B hepatitis (NANBH) is still incomplete. To define the prevalence antibodies against main causative agent NANBH, C virus (HCV) and role some risk factors, we tested sera from 269 patients on chronic dialysis at hemodialysis units in our region central Italy. We utilized recently developed serological assay. Twenty-nine (13.3%) 3 peritoneal (4.8%) were anti-HCV positive. Of these, 13 (40.6%) had to B core antigen (anti-HBc) indicating prior infection....
Granulomatous interstitial nephritis in sarcoidosis (sGIN) is generally clinically silent, but <1% causes acute kidney injury (AKI).This Italian multicentric retrospective study included 39 sarcoidosis-patients with renal involvement at biopsy: 31 sGIN-AKI, 5 other patterns (No-sGIN-AKI), 3 nephrotic proteinuria. We investigate the predictive value of clinical features, laboratory, radiological parameters and histological regarding steroid response. Primary endpoint: incident chronic disease...
Primary myelofibrosis (PMF) is an uncommon form of myeloproliferative neoplasm (MPN) characterized by a proliferation predominantly megakaryocytes and granulocytes in the bone marrow that, fully-developed disease, associated with reactive deposition fibrous connective tissue, extramedullary hematopoiesis (EMH), splenomegaly. Kidney involvement rare clinically presents proteinuria, nephrotic syndrome, renal insufficiency. Renal damage can be due to EMH glomerulopathy. three patterns:...
Isolated complex I deficiency represents the most common mitochondrial respiratory chain defect involved in disorders. Among these, DNA (mtDNA) m.13513G>A pathogenic variant NADH dehydrogenase 5 subunit gene (MT-ND5) has been associated with heterogenous manifestations, including phenotypic overlaps of encephalomyopathy lactic acidosis and stroke-like episodes, Leigh syndrome, Leber's hereditary optic neuropathy (LHON). Interestingly, this specific mutation recently described patients...
Circulating autoantibodies to phospholipase A2 receptor (PLA2R-Ab) are detected in >70% of patients with primary membranous glomerulonephritis (MGN). Detection PLA2R antigen renal tissue, immunohistochemistry (PLA2R IHC), strongly correlates serum PLA2R-Ab, although it is more sensitive. As IHC literature has no univocal interpretation, we suggest reliable criteria for a standard approach the assessment immunostaining differential diagnosis between and secondary MGN. We analyzed expression...
Introduction: Cholesterol crystals and granulomas in tubular lumen interstitium of the kidney are infrequent findings during nephrotic syndrome (NS) poorly described. We attempt to discuss cholesterol NS as a form crystallopathy. Case Presentation: Three cases 207 (1.5%) performed biopsies, between 2001 2019, patients with NS, showed deposition tubules, even some degree interstitial mononuclear inflammation giant cells, fibrosis variable atrophy. Oil Red O staining revealed lipid laden...
End stage renal disease (ESRD) is a chronic with progressively increasing burden. To date, about 3-million people ESRD in Italy can be classified 3/5 K-DOQI, but less than 30% of patients 4-5 refer to nephrology outpatient clinics. Despite such evidence, the current knowledge on burden and, therefore, need manage and possibly prevent complications rather limited. General practitioners (GPs) nephrologists often experience difficulties communicate cooperate concerning appropriate duration...
L’insufficienza renale cronica (IRC) è una patologia in progressivo incremento; Italia circa 3 milioni le persone affette da IRC agli stadi 3-5 sec. K-DOQI, ma percentuale inferiore al 30% dei soggetti 4-5 sarebbe nota presso gli ambulatori nefrologici. A fronte di questa evidenza, che riflette importanti implicazioni nell’ambito della prevenzione primaria, si rilevano, il più delle volte, difficoltà comunicative tra medico medicina generale (MMG) e specialista nefrologo, merito soprattutto...
Journal Article Cytomegalovirus colitis in a patient with recent failure of kidney transplant Get access M. Gaburri, Gaburri U.O. di Nefrologia e Dialisi, Ospedale ‘R. Silvestrini’PerugiaIstituto Malattie Infettive, Universitä PerugiaItaly Search for other works by this author on: Oxford Academic PubMed Google Scholar R. Brugnano, Brugnano Cozzari, Cozzari D. Francisci, Francisci G. Stagni, Stagni U. Buoncristiani Nephrology Dialysis Transplantation, Volume 8, Issue 10, 1993, Pages...