A5084408786- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- HER2/EGFR in Cancer Research
- Cancer Genomics and Diagnostics
- Colorectal Cancer Treatments and Studies
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Diagnosis and Treatment
- Breast Lesions and Carcinomas
- Monoclonal and Polyclonal Antibodies Research
- Breast Cancer Treatment Studies
- RNA modifications and cancer
- Infectious Diseases and Mycology
- Neuroendocrine Tumor Research Advances
- Mycobacterium research and diagnosis
- Cancer, Hypoxia, and Metabolism
- Sarcoma Diagnosis and Treatment
- Actinomycetales infections and treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Urinary and Genital Oncology Studies
- Tumors and Oncological Cases
- Cancer therapeutics and mechanisms
- Estrogen and related hormone effects
- Thyroid Cancer Diagnosis and Treatment
- Molecular Biology Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
University of Perugia
2016-2025
Creative Commons
2023
Azienda Ospedaliera di Perugia
2013-2018
Ospedale Santa Maria
2017
Institute of Normal and Pathological Physiology of the Slovak Academy of Sciences
2008
Istituto Superiore di Sanità
1964
Background: Gefitinib, a specific epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, has activity against approximately 10% of unselected non–small-cell lung cancer (NSCLC) patients. Phosphatidylinositol 3′-kinase (PI3K)/Akt and Ras/Raf/mitogen-activated protein (MAPK), the two main EGFR-signaling pathways, mediate EGFR effects on proliferation survival. Because activation these pathways is dependent phosphorylation status components, we evaluated association between Akt...
BACKGROUND A strong positive correlation exists between the breast cancer tissue content of either urokinase-plasminogen activator (uPA) or plasminogen inhibitor type 1 (PAI-1), quantified in extracts by immunoassays, and survival patients with cancer. Furthermore, several studies assign to urokinase-type receptor (uPAR) a pivotal role triggering proteolytic activity urokinase pathway involved tumor stroma degradation, spread metastasis. However, pattern distribution uPAR normal cancerous...
BACKGROUND Glyoxalase 2 (Glo2), together with glyoxalase 1 (Glo1), forms the main scavenging system of methylglyoxal, a potent pro‐apoptotic agent mainly generated by glycolysis. An increased rate glycolysis is well known signature cancer cells. As survival strategy, Glo1 overexpressed in many human malignant cells, including prostate (PCa), where it plays crucial role progression. No information available on Glo2 same ambit. PCa most common malignancy affecting men western world....
The enzyme indoleamine 2,3-dioxygenase 1 (IDO1) degrade tryptophan (Trp) into kynurenine (Kyn) at the initial step of an enzymatic pathway affecting T cell proliferation. IDO1 is highly expressed in various cancer types and associated with poor prognosis. Nevertheless, serum Kyn/Trp concentration ratio has been suggested as a marker cancer-associated immune suppression. We measured Kyn Trp blood samples wide cohort non-small-cell lung (NSCLC) patients, before they underwent surgery, analyzed...
Besides platinum-based chemotherapy, no established treatment option exists for advanced non-small-cell lung cancer (NSCLC) patients with EGFR exon 20 (Ex20ins) insertion mutations. We sought to determine the clinical outcome of this mutation subtype in immunotherapy era. Thirty NSCLCs Ex20ins mutations were identified, whom 15 had received immune checkpoint blockade (ICB) as monotherapy (N = 12), combination chemotherapy 2) or another immunotherapeutic agent 1). The response rate was...
Abstract Purpose Lung cancer is the leading cause of death worldwide which includes two main types carcinoma distinguished in non-small cell lung (NSCLC) involving epithelial cells, and small (SCLC) affecting neuronal cells hormone secreting cells. Studies have shown a causal link between inflammation/innate immunity onset NSCLC. The present study aimed to evaluate expression Toll-like receptors (TLRs) 4 TLR8 peripheral blood mononuclear (PBMC) tissues patients with NSCLC, useful for future...
Risk assessment and treatment choice remains a challenge in early non-small-cell lung cancer (NSCLC). The aim of this study was to identify novel genes involved the risk relapse (ER) compared no (NR) resected adenocarcinoma (AD) patients using combination high throughput technology computational analysis. We identified 18 (n.13 NR n.5 ER) with stage I AD. Frozen samples ER, corresponding normal (NL) were subjected Microarray quantitative-PCR (Q-PCR). A gene network analysis performed select...
Indoleamine 2,3-dioxygenase 2 (IDO2) is an analog of the tryptophan degrading and immunomodulating enzyme indoleamine 1 (IDO1). Although role IDO1 largely understood, function IDO2 not yet well elucidated. overexpression was documented in some human tumors, but linkage between expression cancer progression still unclear, particular non-small cell lung (NSCLC). Immunohistochemical cellular localization evaluated on 191 formalin-fixed paraffin-embedded resected NSCLC. Correlations expression,...
Pregnane X receptor (PXR) is a master xenobiotic-sensing transcription factor and validated target for immune inflammatory diseases. The identification of chemical probes to investigate the therapeutic relevance still highly desired. In fact, currently available PXR ligands are not selective can exhibit toxicity and/or potential off-target effects. this study, we have identified garcinoic acid as efficient agonist. properties natural molecule specific agonist were demonstrated by screening...
Primary mucinous carcinomas of the skin are very rare. To date, 120 cases have been described in literature. This tumor is a histologic subtype sweat gland carcinoma. Because histopathologic appearance, primary carcinoma can be mistaken for metastasis from extracutaneous sites. We report on two elderly women with arising scalp. Immunohistochemical staining both tumors was positive low-molecular-weight cytokeratin and epithelial membrane antigen. Carcinoembryonic antigen Case 2....
Glyoxalase 2 (Glo2), a metabolic enzyme, is overexpressed in some human cancers which suggests this enzyme may play role tumorigenesis. In prostate cancer (PCa), the of Glo2 has been scarcely investigated and there are no studies addressing causative involvement protein neoplasia. Here, we examined immunohistochemical profile PCa benign adjacent tissues development cell lines. matched normal were obtained from paraffin sections primary 20 patients who had undergone radical prostatectomy....
// Marianna Penzo 1 , Vienna Ludovini 2 Davide Treré Annamaria Siggillino Jacopo Vannucci 3 Guido Bellezza 4 Lucio Crinò Lorenzo Montanaro Department of Experimental, Diagnostic and Specialty Medicine, Alma Mater Studiorum, University Bologna, I-40138, Italy Medical Oncology, S. Maria della Misericordia Hospital, Perugia, I-06156, Thoracic Surgery, Institute Pathological Anatomy Histology, Correspondence to: Montanaro, e-mail: lorenzo.montanaro@unibo.it Keywords: lung cancer,...