A5020130612- Microscopic Colitis
- Inflammatory Bowel Disease
- Celiac Disease Research and Management
- HER2/EGFR in Cancer Research
- Breast Cancer Treatment Studies
- Urinary and Genital Oncology Studies
- Gastrointestinal disorders and treatments
- Helicobacter pylori-related gastroenterology studies
- Genetic factors in colorectal cancer
- Sarcoma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Glycosylation and Glycoproteins Research
- Tumors and Oncological Cases
- Breast Lesions and Carcinomas
- Monoclonal and Polyclonal Antibodies Research
- Colorectal Cancer Screening and Detection
- Cholesterol and Lipid Metabolism
- Oral and Maxillofacial Pathology
- Cutaneous Melanoma Detection and Management
- ATP Synthase and ATPases Research
- Radiomics and Machine Learning in Medical Imaging
- Bladder and Urothelial Cancer Treatments
- Diverticular Disease and Complications
- Melanoma and MAPK Pathways
- Lung Cancer Treatments and Mutations
University of Perugia
2016-2025
Creative Commons
2023
Azienda Ospedaliera di Perugia
2015-2021
Ospedale Santa Maria
2021
University of Milan
2020
Candida albicans is implicated in intestinal diseases. Identifying host signatures that discriminate between the pathogenic versus commensal nature of this human clinically relevant. In present study, we identify IL-9 and mast cells (MCs) as key players commensalism pathogenicity. By inducing TGF-β stromal MCs, pivotally contributes to mucosal immune tolerance via indoleamine 2,3-dioxygenase enzyme. However, Candida-driven MCs also contribute barrier function loss, dissemination,...
Histological mucosal healing has become a paramount target goal to achieve in the treatment of inflammatory bowel diseases. However, there is still lack agreement on best way reach this goal, since numerous histological scores are available worldwide.
Background: Histological changes induced by gluten in the duodenal mucosa of patients with non-coeliac sensitivity (NCGS) are poorly defined. Objectives: To evaluate structural and inflammatory features NCGS compared to controls coeliac disease (CeD) milder enteropathy (Marsh I-II). Methods: Well-oriented biopsies 262 control cases normal gastroscopy histologic findings, 261 CeD, 175 from 9 contributing countries were examined. Villus height (VH, μm), crypt depth (CrD, villus-to-crypt ratios...
Absence of neutrophils is the minimum standard to consider histological remission ulcerative colitis [UC]. The PICaSSO Histological Remission Index [PHRI] a new simple index for UC, based only on detection neutrophils. We evaluate PHRI's correlation with endoscopy and its prognostic value compared other established indices.
Objectives Mucosal healing, and in particular histological mucosal represents the new frontier as a treatment goal for inflammatory bowel diseases. However, assessment of healing is presently somewhat limited by numerous pathological scores available, lack global consensus on how to best assess it. For this reason, availability simple rapid test evaluate state mucosa after would be useful, especially daily routine. Methods To exploit above purpose, we evaluated possible usefulness antibodies...
Liver regeneration is a unique means of studying cell proliferation in vivo. Screening large cDNA library from regenerating liver has previously allowed us to identify and characterize cluster genes encoding proteins with important roles proliferative processes. Here, by examining different rat human tissues as well lines, we characterized highly conserved gene, guanylyl cyclase domain containing 1 (GUCD1), whose modulation occurs cycle progression vitro. High-level expression GUCD1...
Human epidermal growth factor receptor 2 (HER2) is considered to be a therapeutic and prognostic marker in the management of breast carcinoma (BC), although discordance rates between primary metastatic or locally recurrent lesions have been reported.One hundred forty-eight paraffin-embedded BC tissues from patients mean age 59.27 (33-96) years corresponding synchronous lymph node metastases were collected retrospectively studied using immunohistochemistry fluorescence situ hybridization...
We have explored the role of Tm7sf2 gene, which codifies for 3β-hydroxysterol Δ14-reductase, an endoplasmic reticulum resident protein, in sensitivity to stress and resulting inflammatory response. used mouse embryonic fibroblasts, derived from Tm7sf2+/+ Tm7sf2−/− mice, determine vitro effects thapsigargin on NF-κB activation. Our results show that gene controls launch unfolded protein response presides anti-inflammatory loop thus its absence correlates with activation TNFα up-regulation....
Intravascular lymphoma is a rare type of non-Hodgkin mostly B-cell lineage. A few cases intravascular have been found to be NK/T-cell origin, mainly affecting the skin and central nervous system. 54-year-old Caucasian man sought care because 2 weeks history jaundice intermittent fever, not responsive antibiotics antipyretics. Laboratory tests showed low blood oxygen concentration pancytopenia. Serum microbiological were negative. Computerized tomography (CT) scan revealed hepatosplenomegaly...
Primary signet-ring cell carcinoma of the urinary bladder is a rare histologic variant adenocarcinoma. Generally, this neoplasm occurs in middle age and clinical presentation does not differ from most frequent transitional carcinomas. The prognosis frequently poor as at diagnosis it often an advanced phase. It essential to distinguish metastases, different therapeutic strategies are necessary. We present 5 cases primary we used panel histochemical immunohistochemical markers for differential...
Basal cell carcinoma with matrical differentiation is an extremely rare variant. To date, only 12 cases have been described in the literature. This tumor a typical basal basaloid nests containing shadow cells identical to those of pilomatricoma and pilomatrical carcinoma. We present two additional investigated immunoprofile .-catenin osteopontin aim determining both their biological significance possible diagnostic utility. The morphological immunohistochemical features these that we found...
The squamous cell carcinoma of the tongue (SCCT) is biologically and epidemiologically distinct from other oral cavity cancers associated with lower overall survival rates. role HER family members (HER-1, HER-2/neu, HER-3 HER-4) in pathogenesis progression head neck carcinomas has been demonstrated but no report have focused on SCCT. This study investigated, expression all family, a series SCCT studied possible prognostic value correlation various clinico-pathological parameters.HER-1, HER-4...