A5091170737- Antifungal resistance and susceptibility
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Cerebrospinal fluid and hydrocephalus
- Asthma and respiratory diseases
- NF-κB Signaling Pathways
- T-cell and B-cell Immunology
- Estrogen and related hormone effects
- Neuroscience of respiration and sleep
- Spinal Dysraphism and Malformations
- Heart Rate Variability and Autonomic Control
- Immunotherapy and Immune Responses
- Chronic Lymphocytic Leukemia Research
- Cell Adhesion Molecules Research
- Glioma Diagnosis and Treatment
- Autophagy in Disease and Therapy
- Respiratory and Cough-Related Research
- Streptococcal Infections and Treatments
- Tryptophan and brain disorders
- RNA Interference and Gene Delivery
- Virus-based gene therapy research
- Head and Neck Surgical Oncology
- Monoclonal and Polyclonal Antibodies Research
- Neonatal and Maternal Infections
- Cell death mechanisms and regulation
University Hospital of Geneva
2017-2024
Universidade Federal do ABC
2024
University of Perugia
2005-2021
Tel Aviv University
2019-2020
Tel Aviv Sourasky Medical Center
2020
University Hospital of Basel
2019
NYU Langone Health
2019
Children's National
2019
Le Bonheur Children's Hospital
2019
University of Tennessee Health Science Center
2019
By comparing untreated and dexamethasone-treated murine T cell hybridoma (3DO) cells by the differential display technique, we have cloned a new gene, GITR (glucocorticoid-induced tumor necrosis factor receptor family-related gene) encoding member of factor/nerve growth family. is 228-amino acids type I transmembrane protein characterized three cysteine pseudorepeats in extracellular domain similar to CD27 4-1BB intracellular domain. resulted be expressed normal lymphocytes from thymus,...
1. Breuer's hypothesis that the vagus nerves exert a tonic control of respiratory rhythm, in addition to phasic control, was examined.2. Closed-chest cardiopulmonary bypass instituted dogs weighing 20-30 kg anaesthetized with chloralose. Respiratory rhythm recorded from phrenic electroneurogram.3. Complete muscular paralysis induced gallamine triethiodide produced an increase duration inspiration and amplitude integrated electroneurogram. There no consistent effect on expiratory duration....
1. The inhalation of CO(2) produces a tachypnoea only in the presence intact vagus nerves; present study was designed to examine mechanism this phenomenon dog.2. Closed-chest cardiopulmonary bypass established dogs weighing 16-24 kg, anaesthetized with chloralose. When ;bypass' pulmonary blood flow ceased, P(A, CO2) reduced and respiratory rate slowed. 3-10% O(2) could then be inhaled without change level P(a, set at oxygenator.3. addition these concentrations inspired oxygen resulted an...
Candida albicans is implicated in intestinal diseases. Identifying host signatures that discriminate between the pathogenic versus commensal nature of this human clinically relevant. In present study, we identify IL-9 and mast cells (MCs) as key players commensalism pathogenicity. By inducing TGF-β stromal MCs, pivotally contributes to mucosal immune tolerance via indoleamine 2,3-dioxygenase enzyme. However, Candida-driven MCs also contribute barrier function loss, dissemination,...
Abstract Group B Streptococcus (GBS) has developed several strategies to evade immune defenses. We show that GBS induces macrophage (Mφ) membrane permeability defects and apoptosis, prevented by inhibition of calcium influx but not caspases. analyze the molecular mechanisms GBS-induced murine Mφ apoptosis. causes a massive intracellular increase, strictly correlated apoptosis onset. Calcium increase was associated with activation calcium-dependent protease calpain, demonstrated casein...
Abstract γ‐Secretase inhibitors (GSIs) have been proposed for combined therapies of malignancies with a dysregulated Notch signaling. GSI I (Z‐Leu‐Leu‐Nle‐CHO) induces apoptosis some tumor cells by inhibiting proteasome and activity. Alterations in these two cell survival regulators contribute to resistance chronic lymphocytic leukemia (CLL) cells. Here, we investigated the mechanisms whereby increases primary CLL Time‐course studies indicate that initial apoptotic events are inhibition...
Periodontitis (PD) is a chronic disease caused by the host inflammatory response to bacteria colonizing oral cavity. In addition tolerance microbiome, fine-tuned balance of IL-10 levels critical efficiently mount antimicrobial resistance without causing immunopathology. Clinical and animal studies support that adaptive T-helper (Th) cytokines are involved in pathogenesis alveolar bone destruction PD. However, it remains unclear what type Th related human PD progression role has on this...
Summary The ability of the Ber‐H2 (CD30) monoclonal antibody (mAb) to target in vivo Hodgkin (H) and Reed‐Sternberg (R‐S) cells was investigated six patients with advanced Hodgkin's disease (HD). were injected scaled‐up quantities of‘cold’Ber‐H2 mixed‐up a small dose 131 I‐labelled Ber‐H2. binding H R‐S assessed by immunohistologi‐cal analysis tumour biopsies immunoscintigraphy. Only 50% sites imaged at scintigraphy In contrast, immunohistological studies on tissue biopsies, taken 24–72 h...
Group B Streptococcus (GBS) has evolved several strategies to avoid host defences where macrophages are one of main targets. Since pathogens frequently target the cytoskeleton evade immune defences, we investigated if GBS manipulates macrophage cytoskeleton. GBS-III-COH31 in a time- and infection ratio-dependent manner induces great alterations, causing degradation structural regulatory cytoskeletal proteins. β-haemolysin is involved alterations plasma membrane permeability defects which...
Inflammation plays a major role in the pathophysiology of cystic fibrosis (CF), multisystem disease. Anti-inflammatory therapies are, therefore, interest CF, provided that inhibition inflammation does not compromise ability to fight pathogens. Here, we assess whether indole-3-aldehyde (3-IAld), ligand aryl hydrocarbon receptor (AhR), may encompass such an activity. We resorted biopharmaceutical technologies order deliver 3-IAld directly into lung, via dry powder inhalation, or gut, enteric...
The advent of immune checkpoint inhibitors has represented a major boost in cancer therapy, but safety concerns are increasingly being recognized. Indeed, although beneficial at the tumor site, unlocking safeguard mechanism response may trigger autoimmune-like effects periphery, thus making research priority. Herein, we demonstrate that thymosin α1 (Tα1), an endogenous peptide with immunomodulatory activities, can protect mice from intestinal toxicity murine model inhibitor–induced colitis....