A5077975100- Antioxidant Activity and Oxidative Stress
- Genomics, phytochemicals, and oxidative stress
- Glutathione Transferases and Polymorphisms
- Liver Disease Diagnosis and Treatment
- Free Radicals and Antioxidants
- Selenium in Biological Systems
- Vitamin C and Antioxidants Research
- Metabolomics and Mass Spectrometry Studies
- Heavy Metal Exposure and Toxicity
- Adipose Tissue and Metabolism
- Retinoids in leukemia and cellular processes
- Sulfur Compounds in Biology
- Cholesterol and Lipid Metabolism
- Computational Drug Discovery Methods
- Eicosanoids and Hypertension Pharmacology
- Drug Transport and Resistance Mechanisms
- Fatty Acid Research and Health
- Diet, Metabolism, and Disease
- Estrogen and related hormone effects
- Autophagy in Disease and Therapy
- Adipokines, Inflammation, and Metabolic Diseases
- Hops Chemistry and Applications
- Advanced Glycation End Products research
- Dyeing and Modifying Textile Fibers
- Redox biology and oxidative stress
University of Perugia
2016-2025
University of Pavia
2023
Policlinico San Matteo Fondazione
2023
Istituti di Ricovero e Cura a Carattere Scientifico
2015-2023
MultiMedica
2012-2016
Antimetabolites are a class of effective anticancer drugs interfering in essential biochemical processes. 5-Fluorouracil (5-FU) and its prodrug Capecitabine widely used the treatment several solid tumors (gastro-intestinal, gynecological, head neck, breast carcinomas). Therapy with fluoropyrimidines is associated wide range adverse effects, including diarrhea, dehydration, abdominal pain, nausea, stomatitis, hand-foot syndrome. Among 5-FU side increasing attention given to cardiovascular...
Several studies have demonstrated anti-proliferative and pro-apoptotic actions of cannabinoids on various tumours, together with their anti-angiogenic properties. The non-psychoactive cannabinoid cannabidiol (CBD) effectively inhibits the growth different types tumours in vitro vivo down-regulates some pro-angiogenic signals produced by glioma cells. As its properties not been thoroughly investigated to date, given very favourable pharmacological toxicological profile, here, we evaluated...
The aim of this study was to establish the persistence severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on inanimate surfaces such as plastic, stainless steel, and glass during UV-C irradiation which is a physical means commonly utilized in sanitization procedures. viral inactivation rate, virus half-life, percentage titer reduction after were assessed. Infectivity maintained plastic until 120 h steel 72 h. half-life 5.3, 4.4, 4.2 glass, respectively. In all cases, decay >99%...
Viral infections sustain their replication cycle promoting a pro-oxidant environment in the host cell. In this context, specific alterations of levels and homeostatic function tripeptide glutathione have been reported to play causal role cytopathic effects (CPE) virus. study, these aspects were investigated for first time SARS-CoV2-infected Vero E6 cells, reliable well-characterized vitro model infection. SARS-CoV2 markedly decreased cellular thiols, essentially lowering reduced form (GSH)....
Abstract Two recent randomized controlled trials demonstrated improved radiographic, histological and hepatometabolic cues of non-alcoholic steatohepatitis (NASH) in pediatric patients treated with the ω-3 fatty acid docosahexaenoic (DHA) combination vitamin D (VD) or choline (CHO) E (VE), DHA-VD DHA-CHO-VE trials, respectively). In present study we verified nutritional compliance to these DHA-based multivitamin treatments; lipidomics biomarkers reported outcome on NASH indicators were also...
SARS-CoV-2 (COVID-19) infection can cause a severe respiratory distress syndrome. The risk of manifestations and mortality characteristically increase in the elderly presence non-COVID-19 comorbidity. We others previously demonstrated that low molecular weight (LMW) protein thiol/disulfide ratio declines human plasma with age such decline is even more rapid case inflammatory premature aging diseases, which are also associated most complications COVID-19 infection. same LMW observed appears...
Propolis is a resinous mixture produced by honeybees which has been used since ancient times for its useful properties. However, chemical composition and bioactivity may vary, depending on the geographical area of origin type tree bees use collecting pollen. In this context, research aimed to investigate total phenolic content (using Folin-Ciocalteu assay) antioxidant capacity FRAP, DPPH, ABTS assays) three black poplar (Populus nigra L.) propolis (BPP) solutions (S1, S2, S3), as well...
Abstract Melatonin (MLT) plays a role in preserving bone health, function that may depend on homeostatic effects both mature osteoblasts and mesenchymal stem cells (MSCs) of the tissue. In this study, these functions MLT have been investigated rat (femur) human adipose MSC (hMSC) during chronic exposure to low‐grade cadmium (Cd) toxicity, serious public health concern. The vivo findings demonstrate protects against Cd‐induced metabolism disruption accumulation marrow adipocytes, cue impaired...
Abstract Unfolded protein response (UPR) and endoplasmic reticulum (ER) stress are aspects of SARS‐CoV‐2‐host cell interaction with proposed role in the cytopathic inflammatory pathogenesis this viral infection. The NF‐kB pathway these cellular processes remains poorly characterized. When investigated VERO‐E6 cells, SARS‐CoV‐2 infection was found to markedly stimulate expression activity. activation occurs early process (6 hpi) it is associated increased MAPK signaling UPR inducer IRE‐1α....
The metabolism of α-tocopherol (α-TOH, vitamin E) shows marked interindividual variability, which may influence the response to nutritional and therapeutic interventions with this vitamin. Recently, new metabolomics protocols have fostered possibility explore such variability for different metabolites α-TOH so far identified in human blood, i.e., “vitamin E metabolome”, some been reported promote important biological functions. Such advances prompt definition reference values degree these at...
Melatonin (MLT) is a cytoprotective agent holding potential to prevent cadmium (Cd) toxicity and its impact in testicular function fertility. In this study, we explored such porcine pre-pubertal Sertoli cells (SCs). Cd resulted impaired SC viability function, abnormal cellular H2 O2 generation efflux, induction of reductive stress by the upregulation Nrf2 expression activity, cystine uptake glutathione biosynthesis, glutathione-S-transferase P (GSTP) expression, protein glutathionylation...