A5009093219- Heavy Metal Exposure and Toxicity
- Trace Elements in Health
- Environmental Toxicology and Ecotoxicology
- Mercury impact and mitigation studies
- Fish Biology and Ecology Studies
- Microplastics and Plastic Pollution
- Effects and risks of endocrine disrupting chemicals
- Heavy metals in environment
- Aquaculture Nutrition and Growth
- Birth, Development, and Health
- Parkinson's Disease Mechanisms and Treatments
- Bone Metabolism and Diseases
- Renal and related cancers
- Child Nutrition and Water Access
- Toxic Organic Pollutants Impact
- Selenium in Biological Systems
- Aluminum toxicity and tolerance in plants and animals
- Reproductive biology and impacts on aquatic species
- Nanoparticles: synthesis and applications
- Nerve injury and regeneration
- Biomedical Research and Pathophysiology
- Air Quality and Health Impacts
- Comparative Animal Anatomy Studies
- Parasite Biology and Host Interactions
- Immunotoxicology and immune responses
University of Monastir
2015-2024
University of Sousse
2018
Hôpital Mongi Slim
2016
Institut Supérieur de Biotechnologie de Sfax
2007-2015
Czech Academy of Sciences, Institute of Biotechnology
2008
Herein, we further document the protective action of melatonin (MLT) in mitigating cadmium (Cd) effects on adult rat testis. Cd treatment provoked testicular injury, that was documented by histological and biomolecular alterations, i.e., decrease serum testosterone concentration modified sperm parameters. Mainly, both cytoarchitecture blood-testis barrier (BTB) germ cell morphology were perturbed, as highlighted impairment structural (OCN, VANGL, Cx43) regulative (Src FAK) protein levels...
Mitochondria-Associated Endoplasmic Reticulum Membranes (MAMs) mediate the communication between (ER) and mitochondria, playing a fundamental role in steroidogenesis. This study aimed to understand how D-aspartate (D-Asp), well-known stimulator of testosterone biosynthesis spermatogenesis, affects mechanism steroidogenesis rat testes. Our results suggested that D-Asp exerts this function through MAMs, affecting lipid trafficking, calcium signaling, ER stress, mitochondrial dynamics. After 15...
Oxidative stress is a major factor involved in the pathogenesis of renal ischemia/reperfusion (I/R). Exogenous zinc (Zn) was suggested as potent antioxidant; however, mechanism by which it strengthens organ resistance against effects reactive oxygen species (ROS) not yet investigated. The present study aims to determine whether acute chloride (ZnCl 2 ) administration could attenuate endoplasmic reticulum (ER) stress, autophagy, and inflammation after I/R. Rats were subjected either sham...
In order to verify the effects of exposure Cd and Zn on testicular DAAM1 gene protein expression also ascertain their involvement in protective role prevent toxicity Cd‐induced male offspring rats at adult age after gestational lactational exposure, rats, from mothers receiving either tap water, Cd, Zn, or + during gestation lactation periods, were scarified postnatal days (PND) 70. The reproductive organ (testis, epididymis, vesicle seminal) collected, weighed, analyzed. results showed that...
Abstract Melatonin (MLT) plays a role in preserving bone health, function that may depend on homeostatic effects both mature osteoblasts and mesenchymal stem cells (MSCs) of the tissue. In this study, these functions MLT have been investigated rat (femur) human adipose MSC (hMSC) during chronic exposure to low‐grade cadmium (Cd) toxicity, serious public health concern. The vivo findings demonstrate protects against Cd‐induced metabolism disruption accumulation marrow adipocytes, cue impaired...
This paper confirms the damaging effects produced by MP and Cd on testicular activity in rat. Oral treatment with both chemicals resulted damage, documented biomolecular histological alterations, particularly impaired morphometric parameters, increased apoptosis, reduced testosterone synthesis, downregulation of steroidogenic enzyme 3β-HSD. We also demonstrated, for first time, that can affect protein level PTMA, a small peptide regulates germ cell proliferation differentiation....
Abstract The present study was conducted to assess the effects of Cd exposure on estrogen signaling in zebrafish brain, as well potential protective role Zn against Cd‐induced toxicity. For this purpose, transcriptional activation receptors (ERs), aromatase B (Aro‐B) protein expression and molecular related genes were examined vivo using wild‐type transgenic embryos. vitro studies, an ER‐negative glial cell line (U251MG) transfected with different ER subtypes (ERα, ERβ1 ERβ2) also used....