A5050464958- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Cannabis and Cannabinoid Research
- Receptor Mechanisms and Signaling
- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Memory and Neural Mechanisms
- Forensic Toxicology and Drug Analysis
- Adenosine and Purinergic Signaling
- Nicotinic Acetylcholine Receptors Study
- Behavioral Health and Interventions
- Smoking Behavior and Cessation
- Tryptophan and brain disorders
- Attention Deficit Hyperactivity Disorder
- Pancreatic function and diabetes
- GABA and Rice Research
- Biochemical Analysis and Sensing Techniques
- Sleep and Wakefulness Research
- Peroxisome Proliferator-Activated Receptors
- Substance Abuse Treatment and Outcomes
- Biochemical effects in animals
- Regulation of Appetite and Obesity
- Transcranial Magnetic Stimulation Studies
- Obsessive-Compulsive Spectrum Disorders
- Bipolar Disorder and Treatment
Université de Poitiers
2016-2025
Inserm
2015-2025
Laboratoire de Neurosciences Expérimentales et Cliniques
2017-2024
Centre Hospitalier Henri Laborit
2020-2024
Laboratoire de Neurosciences Cognitives
2024
University of Kentucky
2016
Université de Tours
2015
Imagerie et Cerveau
2015
NYU Langone Health
2015
SUNY Upstate Medical University
2015
Although anecdotal reports suggest that cannabis may be used to alleviate symptoms of depression, the psychotropic effects and abuse liability this drug prevent its therapeutic application. The active constituent cannabis, Δ 9 -tetrahydrocannabinol, acts by binding brain CB 1 cannabinoid receptors, but an alternative approach might develop agents amplify actions endogenous cannabinoids blocking their deactivation. Here, we show URB597, a selective inhibitor enzyme fatty-acid amide hydrolase,...
An increase in the extracellular concentration of dopamine nucleus accumbens (NAc) is believed to be one main mechanisms involved rewarding and motor-activating properties psychostimulants such as amphetamines cocaine. Using <i>in vivo</i> microdialysis freely moving rats, we demonstrate that systemic administration behaviorally relevant doses caffeine can preferentially levels glutamate shell NAc. These effects could reproduced by a selective adenosine A1 receptor antagonist but not A2A...
Environmental conditions can dramatically influence the behavioral and neurochemical effects of drugs abuse. For example, stress increases reinforcing plays an important role in determining vulnerability to develop drug addiction. On other hand, positive conditions, such as environmental enrichment, reduce psychostimulants may provide protection against development However, whether enrichment be used "treat" addiction has not been investigated. In this study, we first exposed mice induced...
Although endogenous cannabinoid systems have been implicated in the modulation of rewarding effects abused drugs and food, little is known about direct ligands for receptors on brain reward processes. Here we show first time that intravenous administration anandamide, an ligand receptors, its longer-lasting synthetic analog methanandamide, increase extracellular dopamine levels nucleus accumbens shell awake, freely moving rats, effect characteristic most by humans. Anandamide produced two...
Activation or blockade of cannabinoid CB1 receptors markedly alters many effects opioids. In the present study, we investigated whether antagonist (N-piperidinyl-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxamide (SR-141716A) could alter reinforcing heroin in rats. A Delta9-tetrahydrocannabinol (THC) drug-discrimination procedure was first used to determine effective doses SR-141716A and optimal pretreatment times for self-administration studies. Subsequently,...
The recent findings that Δ9 tetrahydrocannabinol ( THC), the active agent in marijuana and hashish, (1) is self-administered intravenously, (2) potentiates rewarding effects of electrical brain stimulation, (3) can establish conditioned place preferences laboratory animals, suggest these drugs activate biologically primitive reward mechanisms. Here, we identify two chemical trigger zones for stimulant actions THC. Microinjections THC into posterior ventral tegmental area (VTA) or shell...
Several studies have demonstrated anti-proliferative and pro-apoptotic actions of cannabinoids on various tumours, together with their anti-angiogenic properties. The non-psychoactive cannabinoid cannabidiol (CBD) effectively inhibits the growth different types tumours in vitro vivo down-regulates some pro-angiogenic signals produced by glioma cells. As its properties not been thoroughly investigated to date, given very favourable pharmacological toxicological profile, here, we evaluated...
Previous studies have demonstrated opposing roles for adenosine A1 and A2A receptors in the modulation of extracellular levels glutamate dopamine striatum. In present study, acute systemic administration motor-activating doses receptor antagonist MSX-3 significantly decreased shell rat nucleus accumbens (NAc) counteracted both release induced by either CPT or caffeine. Furthermore, exposure to caffeine drinking water (1 mg/mL, 14 days) resulted tolerance effects injection caffeine, but not...
Inhibitors of fatty acid amide hydrolase (FAAH) increase endogenous levels anandamide (a cannabinoid CB 1 -receptor ligand) and oleoylethanolamide palmitoylethanolamide (OEA PEA, ligands for α-type peroxisome proliferator-activated nuclear receptors, PPAR-α) when where they are naturally released in the brain. Using a passive-avoidance task rats, we found that memory acquisition was enhanced by FAAH inhibitor URB597 or PPAR-α agonist WY14643, these enhancements were blocked antagonist MK886....
Anandamide is an endogenous ligand for brain cannabinoid CB<sub>1</sub> receptors, but its behavioral effects are difficult to measure due rapid inactivation. Here we used a drug-discrimination procedure test the hypothesis that anandamide, given i.v. or i.p., would produce discriminative like those of δ-9-tetrahydrocannabinol (THC) in rats when metabolic inactivation was inhibited. We also vivo microdialysis investigate on dopamine levels nucleus accumbens shell rats. When injected i.v.,...