A5107301111- Angiogenesis and VEGF in Cancer
- Immune Cell Function and Interaction
- Cell Adhesion Molecules Research
- Cancer, Lipids, and Metabolism
- Immune cells in cancer
- Chemokine receptors and signaling
- Cancer, Hypoxia, and Metabolism
- Protease and Inhibitor Mechanisms
- Immunotherapy and Immune Responses
- HIV Research and Treatment
- Glycosylation and Glycoproteins Research
- Viral-associated cancers and disorders
- Retinoids in leukemia and cellular processes
- Proteoglycans and glycosaminoglycans research
- Edible Oils Quality and Analysis
- Lymphoma Diagnosis and Treatment
- RNA Interference and Gene Delivery
- COVID-19 Clinical Research Studies
- Cancer Treatment and Pharmacology
- Chemotherapy-induced cardiotoxicity and mitigation
- Metabolism, Diabetes, and Cancer
- Inflammatory mediators and NSAID effects
- Cancer-related molecular mechanisms research
- PI3K/AKT/mTOR signaling in cancer
- Cancer Immunotherapy and Biomarkers
University of Insubria
2015-2024
MultiMedica
2015-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2015-2024
Ospedale Santa Maria
2014-2015
University of Messina
2014
Imperial College London
2011-2012
Georgia Institute of Technology
2007-2012
Alleanza Contro il Cancro
1996-2011
University of Milan
2011
Dartmouth College
2007
A heparan sulfate proteoglycan is a component of all basement membranes. This molecule consists three side chains linked to large core protein approximately 400 kDa. We have isolated seven overlapping murine cDNA clones that encode the entire mRNA sequence 12.685 kilobases this molecule. has single open reading frame 3,707 amino acids encodes for 396 Identical or near identical matchups with nine peptide sequences derived from Engelbreth-Holm-Swarm tumor were found deduced sequence. Sequence...
Antimetabolites are a class of effective anticancer drugs interfering in essential biochemical processes. 5-Fluorouracil (5-FU) and its prodrug Capecitabine widely used the treatment several solid tumors (gastro-intestinal, gynecological, head neck, breast carcinomas). Therapy with fluoropyrimidines is associated wide range adverse effects, including diarrhea, dehydration, abdominal pain, nausea, stomatitis, hand-foot syndrome. Among 5-FU side increasing attention given to cardiovascular...
The tumor microenvironment can polarize innate immune cells to a proangiogenic phenotype. Decidual natural killer (dNK) show an angiogenic phenotype, yet the role for NK lymphoid in angiogenesis remains be defined. We investigated from patients with surgically resected non-small cell lung cancer (NSCLC) and controls using flow cytometric functional analyses. CD56+CD16- subset NSCLC patients, which represents predominant tumors minor adjacent peripheral blood, was associated vascular...
Abstract SARS-CoV-2 is characterized by a spike protein allowing viral binding to the angiotensin-converting enzyme (ACE)-2, which acts as receptor and expressed on surface of several pulmonary extra-pulmonary cell types, including cardiac, renal, intestinal endothelial cells. There evidence that also cells are infected SARS-COV-2, with subsequent occurrence systemic vasculitis, thromboembolism disseminated intravascular coagulation. Those effects, together “cytokine storm” involved in worse...
The HIV-1 Tat protein is a potent chemoattractant for monocytes. We observed that shows conserved amino acids corresponding to critical sequences of the chemokines, family molecules known their ability attract Synthetic and peptide (CysL 24–51 ) encompassing “chemokine-like” region induced rapid transient Ca 2+ influx in monocytes macrophages, analogous β-chemokines. Both monocyte migration mobilization were pertussis toxin sensitive cholera insensitive. Cross-desensitization studies...
The α3β1 integrin is elevated in several types of metastatic tumor and has been associated with increased migration invasion. Our analysis a series mammary carcinomas different histotypes their corresponding metastases demonstrated significantly expression the metastases. We therefore studied human breast carcinoma cell lines its association invasive phenotype. MDA-MB-231 line expressed high levels β1, α2, α3, α5, α6 subunits along moderate αvβ3 integrin. This was highly migratory most using...
Abstract The angiogenic activity of CXC-ELR+ chemokines, including CXCL8/IL-8, CXCL1/macrophage inflammatory protein-2 (MIP-2), and CXCL1/growth-related oncogene-α in the Matrigel sponge angiogenesis assay vivo, is strictly neutrophil dependent, as depletion animals completely abrogates response. In this study, we demonstrate that mice deficient src family kinases, Hck Fgr (hck−/−fgr−/−), are unable to develop an response CXCL1/MIP-2, although they respond normally vascular endothelial...
Human immunodeficiency virus type 1 (HIV-1) Tat protein is released from infected cells. Extracellular enters the cell where it stimulates transcriptional activity of HIV-long terminal repeat (LTR) and endogenous genes. Heparin modulates angiogenic (Albini, A., Benelli, R., Presta, M., Rusnati, Ziche, Rubartelli, Paglialunga, G., Bussolino, F., Noonan, D. (1996) <i>Oncogene</i> 12, 289-297) (Mann, Frankel, A. (1991) <i>EMBO J.</i> 10, 1733-1739) extracellular Tat. Here we demonstrate that...
Abstract Purpose: Green tea consumption has been linked to a reduced occurrence of some tumor types. Current data indicate that the principal mediator this chemopreventive effect is epigallocatechin-3-gallate (EGCG), most abundant polyphenol found in dried leaves. Here, we examined effects compound on two key cell populations typically involved growth: cells and endothelial cells. Experimental Design: The green EGCG were tested highly vascular Kaposi’s sarcoma (KS) model panel vivo vitro...
Chronic inflammation is a major risk factor for the development and metastatic progression of cancer. We have previously reported that chemopreventive polyphenol Curcumin inhibits expression proinflammatory cytokines CXCL1 ‐2 leading to diminished formation breast prostate cancer metastases. In present study, we analyzed effects on miRNA its correlation anti‐tumorigenic properties this natural occurring polyphenol. Using microarray analyses, show here modulates series miRNAs, including...
Xanthohumol (XN), the principal flavonoid of hop plant (Humulus lupulus L.) and a constituent beer, has been suggested to have potential cancer chemopreventive activities. We observed that most agents show antiangiogenic properties in vitro vivo, concept we termed "angioprevention." Here for first time XN can inhibit growth vascular tumor vivo. Histopathology vivo angiogenesis assays indicated inhibition was involved. Further, mechanisms its related endothelial cell activities vitro....