A5001745874- Neuropeptides and Animal Physiology
- Receptor Mechanisms and Signaling
- Chemical Synthesis and Analysis
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Colorectal Cancer Treatments and Studies
- Biochemical and Molecular Research
- Peptidase Inhibition and Analysis
- Catalytic Cross-Coupling Reactions
- Alzheimer's disease research and treatments
- Click Chemistry and Applications
- Plant Pathogens and Fungal Diseases
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Carbohydrate Chemistry and Synthesis
- Cancer, Hypoxia, and Metabolism
- Coordination Chemistry and Organometallics
- Postharvest Quality and Shelf Life Management
- RNA Interference and Gene Delivery
- Immunotherapy and Immune Responses
- Phosphodiesterase function and regulation
- Nanoparticle-Based Drug Delivery
- Dementia and Cognitive Impairment Research
- Hemoglobinopathies and Related Disorders
- Hypothalamic control of reproductive hormones
- Sleep and Wakefulness Research
University of Ferrara
2016-2025
University of Foggia
2024
University of Modena and Reggio Emilia
2022
University of Verona
2022
Excel Life Sciences (India)
2022
Gdańsk Medical University
2022
Aboca (Italy)
2022
Center for Translational Neurophysiology of Speech and Communication
2014
University of Molise
2001-2005
This study aimed to compare phenotypic and genetic characteristics of Lactobacillus rhamnosus strains isolated at the end ripening Parmigiano Reggiano cheese investigate an important prerequisite probiotic interest, such as capability survive low pH in presence bile salts. The use API 50 CH, RAPD-PCR analysis species-specific PCR allowed ascertain identity 63 L. strains. Three from cheese, ATCC 7469T commercial strain GG were assayed estimate resistance various stress factors reproducing...
Double glycosylation of cysteine-containing peptides has been carried out by a one-pot two-step sequence comprising selective S-propargylation followed photoinduced (λ max 365 nm) free-radical hydrothiolation with glycosyl thiols. Conditions were established for the sequential introduction two different thiol residues such as and biotinyl derivative.
The foliar application of zeolites has been proven to positively affect plant physiology suggesting that it could improve growth, however, this topic little studied. Two field trials were carried out (in 2021 and 2022) study the potential beneficial effect natural zeolite particle films on processing tomato crops. Natural i) clinoptinolite + mordenite (CubZeo) ii) micronized (BigZeo) sprayed onto plants six times in central crop cycles. In both trials, BigZeo promoted leaf fruit dry mass...
The NLRP3 inflammasome is a critical component of innate immunity that senses diverse pathogen- and host-derived molecules. However, its aberrant activation has been associated with the pathogenesis multiple diseases, including cancer. In this study, we designed synthesized series aryl sulfonamide derivatives (ASDs) to inhibit inflammasome. Among these, compounds 6c, 7n, 10 specifically inhibited at nanomolar concentrations without affecting NLRC4 AIM2 inflammasomes. Furthermore,...
Recent cardiology research studies have reported the role, function, and structure of mitochondrial permeability transition pore (mPTP) shown that its opening plays a key role in progression myocardial cell death secondary to reperfusion. In this manuscript, we validated new pharmacological approach as an adjunct reperfusion infarction (MI) treatment describe discovery, optimization, structure–activity relationship (SAR) first small-molecule mPTP inhibitors based on...
The synthesis and antiproliferative activity of new benzimidazole derivatives bearing an hydrazone mojety at the 2-position is described. N'-(4-arylidene)-1H-benzo[d]imidazole-2-carbohydrazides were evaluated for their cytostatic toward murine leukemia (L1210), human T-cell (CEM), cervix carcinoma (HeLa) pancreas cells (Mia Paca-2). A preliminary structure-activity relationship could be defined. Some compounds possess encouraging consistent activity, having IC50 values in low micromolar range.
Abstract Late onset Alzheimer disease (LOAD) is traditionally considered as a separate from vascular dementia (VAD). However, growing evidence suggests that β-amyloid (Aβ) accumulation, initiates LOAD-related neurodegeneration, preceded by events. Previous in vitro studies showed β-secretase 1 (BACE1), the key-enzyme of amyloidogenesis, upregulated cerebrovascular insult; moreover, its activity increased both brain and serum LOAD patients. We aimed to investigate whether BACE1 altered also...
Advanced age is associated with severe symptoms and death upon SARS-CoV-2 infection. Virus-specific CD8 + T-cell responses have shown to be protective toward critical COVID-19 manifestations, suggesting that suboptimal cellular immunity may contribute the age-pattern of disease. The induction a response against an emerging pathogen like relies on activation naive T cells. To investigate whether primary this virus defective in advanced age, we used vitro approach prime SARS-CoV-2-specific...
Thiazolium salt pre-catalysts have been immobilized on silica and monolithic polystyrene their activity was tested under batch conditions in three model umpolung reactions, namely the benzoin condensation of benzaldehyde, acyloin-type biacetyl, Stetter reaction biacetyl with trans-chalcone. A prerequisite study has utilization environmentally benign water ethanol solvents. After having established higher performance thiazolium carbene catalysts, effectiveness flow regime by fabricating...
Protein misfolding and amyloid formation are associated with various human diseases including Alzheimer's disease (AD), Parkinson's (PD), Type-2 Diabetes mellitus (T2DM). No disease-modifying therapeutics available for them. Despite the lack of sequence homology between corresponding proteins, aromatic residues recognized as common key motifs in stabilization structures via π–π stacking. Thus, targeting recognition interfaces could be a useful approach inhibiting well disrupting preformed...
Drug–target interaction, cellular internalization, and target engagement should be addressed to design a lead with high chances of success in further optimization stages. Accordingly, we have designed conjugates folic acid anticancer peptides able bind human thymidylate synthase (hTS) enter cancer cells through folate receptor α (FRα) highly expressed by several cells. Mechanistic analyses molecular modeling simulations shown that these the hTS monomer–monomer interface affinities over 20...
Age-related changes in the immune system are thought to underlie vulnerability of elderly individuals emerging viral diseases, such as coronavirus disease 2019 (COVID-19). In this study, we used a fully validated vitro approach determine how age impacts generation de novo CD8+ T cell responses against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), causative agent COVID-19. Our data revealed generalized deficit ability prime differentiation naïve precursors into effector cells...
Abstract The hitherto unreported ability of the methylsulfinyl carbanion (dimsyl anion) to generate acyl anion equivalents is described. dimsyl anion, in fact, efficiently catalyzes chemoselective intermolecular cross‐benzoin condensations diaryl α‐diketones (benzils) with various aromatic and aliphatic aldehydes give corresponding aryl‐aryl aryl‐alkyl benzoin benzoates an atom‐economic fashion. acts as environmentally friendly alternative toxic cyanide it obtained by situ deprotonation...
An efficient method for the N-heterocyclic carbene (NHC)-catalyzed conjugate addition of acetyl anions to various α,β-unsaturated acceptors (Stetter reaction) has been optimized by using 2,3-butandione (biacetyl) as an alternative surrogate acetaldehyde. The disclosed procedure proved be compatible with microwave dielectric heating reaction time reduction and use different linear α-diketones acyl anion donors (e.g. 3,4-hexanedione propionyl additions). Moreover, unprecedented umpolung...
Increasing attention has been recently devoted to 89Zr(IV) and 68Ga(III) radionuclides, due their favorable decay characteristics for positron emission tomography (PET). In the present paper, a deep investigation is presented on Ga(III) Zr(IV) complexes with series of tri-(H3L1, H3L3, H3L4 desferrioxamine E, DFOE) tetrahydroxamate (H4L2) ligands. Herein, we describe rational design synthesis two cyclic complexing agents (H3L1 H4L2) bearing three four hydroxamate chelating groups,...
The urotensin-II receptor (UTR) is a class A GPCR that predominantly binds to the pleiotropic cyclic peptide (U-II). U-II constrained by disulfide bridge induces β-turn structure and pseudo-irreversibly UTR believed result in structural rearrangement of receptor. However, it not well understood how nature reorganization results G-protein activation. Here we describe series peptidomimetics incorporating non-reducible bond surrogate investigate feasibility native G protein-coupled through...