A5024858680- Weed Control and Herbicide Applications
- Receptor Mechanisms and Signaling
- Agriculture, Plant Science, Crop Management
- Odor and Emission Control Technologies
- Neuropeptides and Animal Physiology
- Chemical Synthesis and Analysis
- Agricultural Science and Fertilization
- Pesticide and Herbicide Environmental Studies
- Crop Yield and Soil Fertility
- Hydrology and Sediment Transport Processes
- IL-33, ST2, and ILC Pathways
- EEG and Brain-Computer Interfaces
- Magnetic and Electromagnetic Effects
- Powdery Mildew Fungal Diseases
- Monoclonal and Polyclonal Antibodies Research
- Sphingolipid Metabolism and Signaling
- Hydraulic flow and structures
- Synthesis and biological activity
- Structural mechanics and materials
- Pharmacological Effects and Assays
- Potato Plant Research
- Hygrothermal properties of building materials
- Inflammasome and immune disorders
- Pesticide Residue Analysis and Safety
- Plant Pathogens and Fungal Diseases
University of Ferrara
2021-2023
University of Bologna
2020
University of California, San Diego
2005
The NLRP3 inflammasome is a critical component of innate immunity that senses diverse pathogen- and host-derived molecules. However, its aberrant activation has been associated with the pathogenesis multiple diseases, including cancer. In this study, we designed synthesized series aryl sulfonamide derivatives (ASDs) to inhibit inflammasome. Among these, compounds 6c, 7n, 10 specifically inhibited at nanomolar concentrations without affecting NLRC4 AIM2 inflammasomes. Furthermore,...
The nociceptin/orphanin FQ (N/OFQ)/N/OFQ receptor (NOP) system controls different biological functions including pain and cough reflex. Mixed NOP/opioid agonists elicit similar effects to strong opioids but with reduced side effects. In this work, 31 peptides the general sequence [Tyr/Dmt1,Xaa5]N/OFQ(1-13)-NH2 were synthesized pharmacologically characterized for their action at human recombinant receptors. best results in terms of NOP versus mu opioid potency obtained by substituting both...
Neuropeptide S modulates important neurobiological functions including locomotion, anxiety, and drug abuse through interaction with its G protein-coupled receptor known as neuropeptide (NPSR). NPSR antagonists are potentially useful for the treatment of substance disorders against which there is an urgent need new effective therapeutic approaches. Potent
Plant-derived remedies rich in chalcone-based compounds have been known for centuries the treatment of specific diseases, and nowadays, fascinating chalcone framework is considered a useful and, above all, abundant natural chemotype. Velutone F, new chalconoid from Millettia velutina, exhibits potent effect as an NLRP3-inflammasome inhibitor; search natural/non-natural lead NLRP3 inhibitors current topical subject medicinal chemistry. The details our work toward synthesis velutone F unknown...
We report the synthesis, biological activity and conformational analysis of analogs cyclic hexapeptide L-363,301, c[Pro6-Phe7-D-Trp8-Lys9-Thr10-Phe11] (numbering as in native hormone somatostatin-14). The d-Trp position 8 was replaced with (2R,3S)- (2R,3R)-beta-MeTrp respectively, an added methyl group beta Trp. objective our study to determine potency selectivity generated by constraint upon binding human somatostatin receptors hsst1-5. synthesized building blocks enantioselectively...
Abstract Introduction We aimed to create standardized protocol for language examination in patients who underwent video-EEG recording and assessed its efficacy the characterization of ictal impairment, ability differentiate this from impaired awareness, interobserver reliability clinical practice. Methods From our database recordings, we selected a representative sample 63 focal seizures with presumed impairment. A multidisciplinary team epileptologists, EEG technicians, speech therapists...