A5048261038- Asymmetric Synthesis and Catalysis
- Chemical Synthesis and Analysis
- Synthetic Organic Chemistry Methods
- Carbohydrate Chemistry and Synthesis
- Synthesis and Reactions of Organic Compounds
- Photoreceptor and optogenetics research
- Chemical Reaction Mechanisms
- X-ray Diffraction in Crystallography
- Chemical synthesis and alkaloids
- Crystallization and Solubility Studies
- Phosphorus compounds and reactions
- Chemical Synthesis and Reactions
- Photochromic and Fluorescence Chemistry
- Synthesis and Catalytic Reactions
- Analytical Chemistry and Chromatography
- Microbial Natural Products and Biosynthesis
- Synthesis and Biological Evaluation
- Organophosphorus compounds synthesis
- Organic and Inorganic Chemical Reactions
- Synthesis of heterocyclic compounds
- Organic Chemistry Cycloaddition Reactions
- Advanced Synthetic Organic Chemistry
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Supramolecular Chemistry and Complexes
- Molecular spectroscopy and chirality
University of Ferrara
2011-2023
Bowling Green State University
2009-2010
Universidad de Extremadura
2010
University of Siena
2001-2010
Universidad de La Rioja
2009
Center for Translational Neurophysiology of Speech and Communication
1995
University of Bologna
1990
Istituto di Farmacologia Traslazionale
1984-1985
Single molecules that act as light-energy transducers (e.g., converting the energy of a photon into atomic-level mechanical motion) are examples minimal molecular devices. Here, we focus on switch designed by merging conformationally locked diarylidene skeleton with retinal-like Schiff base and capable mimicking, in solution, different aspects transduction visual pigment Rhodopsin. Complementary ab initio multiconfigurational quantum chemistry-based computations time-resolved spectroscopy...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA new approach to kainoids through tandem Michael reaction methodology: application the enantioselective synthesis of (+)- and (-)-.alpha.-allokainic acid formal (-)-.alpha.-kainic acidAchille Barco, Simonetta Benetti, Giampiero Spalluto, Alberto Casolari, Gian P. Pollini, Vinicio ZaniratoCite this: J. Org. Chem. 1992, 57, 23, 6279–6286Publication Date (Print):November 1, 1992Publication History Published online1 May 2002Published inissue 1...
Designing and testing biomimetic switches: Multireference perturbation theory is used to model a light-driven molecular switch featuring the same photoisomerization mechanism as chromophore of visual pigment rhodopsin (see picture; QM/MM: quantum mechanics/molecular mechanics). By exploiting synthetic route based on nitrilium-cation cyclization, it was shown that designed system can indeed be prepared characterized.
We report the results of a multidisciplinary research effort where methods computational photochemistry and retrosynthetic analysis/synthesis have contributed to preparation novel N-alkylated indanylidene−pyrroline Schiff base featuring an exocyclic double bond permanent zwitterionic head. show that, due its large dipole moment efficient photoisomerization, such system may constitute prototype generation electrostatic switches achieving reversible light-induced change on order 30 D. The...
Protonated Schiff bases (PSBs) of polyenals constitute a class light-driven switchers selected by biological evolution that provide model compounds for the development artificial molecular devices or motors. In present paper, our primary target is to show, through combined computational and experimental studies, it possible approach design PSBs suitable such applications. Below, we use methods photochemistry characterize prototype biomimetic...
A new family of biomimetic photoactivated molecular switches based in the retinal chromophore is described. Expedient synthesis allows a library compounds with different substitution pattern, including chiral substituents, to be obtained. The effect substitution, solvent, and light source on photoisomerization step has been assessed. absorption maximum red-shifted ca. 50 nm respect related systems rotation now easily achieved by using visible light.
Pseudomonas aeruginosa is a Gram-negative bacterium that commonly infects subjects with weakened immune system causing deadly infections above all at pulmonary level. During infection, P. produces well-organized bacterial structure, called biofilm, activating the quorum-sensing (QS) signaling, mechanism of gene regulation. In this work, we synthesized already known QS inhibitors (QSi) designed on scaffold N-(3-oxododecanoyl) homoserine lactone (3O-C12-HSL) molecule and conjugated them...