A5009309469- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- EEG and Brain-Computer Interfaces
- Esophageal Cancer Research and Treatment
- Neuroscience and Neuropharmacology Research
- Functional Brain Connectivity Studies
- Long-Term Effects of COVID-19
- Gastric Cancer Management and Outcomes
- Neurological disorders and treatments
- Genetics and Neurodevelopmental Disorders
- Esophageal and GI Pathology
- Autoimmune Neurological Disorders and Treatments
- Neural dynamics and brain function
- Cancer Genomics and Diagnostics
- Genomics and Rare Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Lung Cancer Treatments and Mutations
- Cerebrospinal fluid and hydrocephalus
- Metabolism and Genetic Disorders
- Glycogen Storage Diseases and Myoclonus
- Amino Acid Enzymes and Metabolism
- Bacterial Infections and Vaccines
- COVID-19 Clinical Research Studies
- Neuroscience of respiration and sleep
- Gastroesophageal reflux and treatments
University of Bologna
2016-2025
Istituto delle Scienze Neurologiche di Bologna
2013-2025
McGill University Health Centre
2022-2025
McGill University
2009-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2013-2024
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2020-2024
Azienda Socio Sanitaria Territoriale Lariana
2024
Surgical Specialties (Canada)
2024
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
2024
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
2024
Importance Women with epilepsy (WWE) require treatment antiseizure medications (ASMs) during pregnancy, which may be associated an increased risk of major congenital malformations (MCMs) in their offspring. Objective To investigate the prevalence MCMs after prenatal exposure to 8 commonly used ASM monotherapies and changes MCM over time. Design, Setting, Participants This was a prospective, observational, longitudinal cohort study conducted from June 1999 October 2022. Since 1999, physicians...
To explore the neuropsychological profile and integrity of olfactory network in patients with COVID-19-related persistent dysfunction (OD).Patients OD underwent assessment Sniffin' Sticks evaluation. Additionally, both a control group brain MRI, including T1-weighted resting-state functional MRI (rs-fMRI) sequences on 3 T scanner. Morphometrical properties were evaluated olfaction-associated regions; rs-fMRI data analysed using graph theory at whole-brain level within standard parcellation...
Abstract Background Epilepsy significantly impacts on morbidity and mortality. Understanding hospitalization mortality risks in persons with epilepsy (PWE) is essential for improving healthcare strategies. We aimed to investigate the risk causes of PWE compared a matched general population cohort. Methods The EpiLink Bologna historical cohort study analyzed adult period 2018–2019. A control was used comparison. Clinical data were linked health administrative data. grouped into focal...
Headache and epilepsy are two relatively common neurological disorders their relationship is still a matter of debate. Our aim was to estimate the prevalence clinical features inter-ictal (inter-IH) peri-ictal headache (peri-IH) in patients with epilepsy. All aged ≥ 17 years referring our tertiary Epilepsy Centre were consecutively recruited from March May 2011 July 2012. They underwent semi-structured interview including International Classification Disorders (ICHD-II) criteria diagnose...
Abstract Objective To report on efficacy and safety of intravenous immunoglobulin (IVIg) therapy in a case series patients with COVID-19-related encephalopathy. Methods We retrospectively collected data all COVID-19 hospitalized at two Italian hospitals who developed encephalopathy during disease course were treated IVIg. Results Five (two females, mean age 66.8 years) after 12.6 days, since the onset respiratory/constitutional symptoms related to COVID-19. Four suffered severe respiratory...
We report our single-center experience on the neurological manifestations of long COVID.This is a retrospective observational study. All consecutive patients referred to COVID outpatient clinic institute from January 21 2021 December 9 underwent general objective examination. Treatments and investigations (brain MRI, neuropsychological evaluation, or others) were prescribed an individual basis as per standard clinical practice. A follow-up visit was performed when appropriate. Descriptive...
<title>Abstract</title> Background Esophageal adenocarcinoma (EAC) is the sixth most deadly cancer worldwide, with increasing incidence in North America. As no targeted therapy or immunotherapy has revolutionized management of EAC, chemotherapy only standard care. Most patients EAC experience poor outcomes because inherent acquired resistance to chemotherapy. Methods Adapting a patient-centered approach, we leveraged microfluidic cell culture technology platform (Emulate), organoids derived...
Objectives To describe the occurrence of secondary sclerosing cholangitis in critically ill patients (SC-CIP) with febrile infection-related epilepsy syndrome (FIRES). Methods Monocentric retrospective analysis all adult FIRES admitted from January 2020 to December 2024. Results Four (3 males) a mean age 24 years (range: 18–40 years) and no significant medical history presented cryptogenic FIRES. They required treatment antiseizure medications (mean: 9; range: 8–10), anesthetics (propofol,...
Studies of functional neurosurgery and electroencephalography in Parkinson's disease have demonstrated abnormally synchronous activity between basal ganglia motor cortex. Functional neuroimaging studies investigated brain dysfunction during task or resting state primarily shown altered patterns activation connectivity for areas. L-dopa administration relatively normalized these alterations. The aim this pilot study was to examine the effects on early-stage PD, as revealed by simultaneous...
Objectives: We explored the impact of coronavirus disease-19 (COVID-19) emergency on health people with epilepsy (PwE). also investigated their attitude toward telemedicine. Methods: The PubMed database up to September 10, 2020 was searched for questionnaire-based studies conducted in PwE during COVID-19 emergency, and literature retrieved reviewed. In addition, all patients who had a telephone consultation our center between May 7 July 31, were invited fill 57-item online questionnaire...
Summary We prospectively examined the effect of antiepileptic ( AED ) cotherapy on steady state plasma concentrations perampanel PMP in epileptic patients. classified s as strong enzyme inducers (carbamazepine, phenobarbital, phenytoin, oxcarbazepine), not inducers/not inhibitors (levetiracetam, lamotrigine, topiramate, rufinamide, lacosamide, zonisamide, clobazam), and (valproic acid [ VPA ]). The main outcome was comparison concentration to weight‐adjusted dose ratio (C/D; [μg/mL]/mg kg −1...
Purpose. To examine the ability of BOLD response to EEG spikes assess epileptogenicity lesion in patients with focal cortical dysplasia (FCD). Method. Patients epilepsy and FCD who underwent 3T EEG-fMRI from 2006 2010 were included. Diagnosis was based on neuroradiology (MRI+), or histopathology MRI-negative cases (MRI-). 120 min recording session. Spikes similar those recorded outside scanner marked filtered EEG. The (in MRI+) removed cortex MRI-) anatomical T1 sequence, blindly response,...
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Introduction: Neurological manifestations are emerging as relatively frequent complications of corona virus disease 2019 (COVID-19), including stroke and encephalopathy. Clinical characteristics the latter heterogeneous not yet fully elucidated, while pathogenesis appears related to neuroinflammation in a subset patients. Case: A middle-aged man presented with acute language disturbance at emergency department. Examination revealed expressive aphasia, mild ideomotor slowing, severe...
Data on COVID-19 outcomes in persons with epilepsy (PWE) are scarce and inconclusive. We aimed to study the risk of hospitalization death for a large cohort PWE from March 1, 2020 October 31, 2021.The historical design (EpiLink Bologna) compared adult grouped into people focal (PFE), idiopathic generalized (PIGE), developmental and/or epileptic encephalopathy (PDEE), population matched (ratio 1:10) age, sex, residence, comorbidity (assessed multisource score), living local health trust...
Most cases of sudden unexpected death in epilepsy (SUDEP) follow a seizure, and most deaths occur while people are bed, presumably sleeping. Nocturnal seizures reported to be risk factor for SUDEP. People with nocturnal frontal lobe (NFLE) have predominantly or exclusively during sleep, often many times per night. The present study aimed assess whether NFLE represents high-risk condition SUDEP.The retrospectively assessed the incidence SUDEP cohort reconstructed from dedicated database...
To identify structural and/or metabolic alterations in patients with sleep-related hypermotor epilepsy (SHE) using magnetic resonance imaging (MRI) and proton MR spectroscopy (1H-MRS).Nineteen SHE (seven males; 34.7 ± 9.7 years, mean age standard deviation) 17 matched healthy volunteers 34.0 8.9 years) were included the study. In all patients, diagnosis of was confirmed by video-polysomnographic recording seizures. Semiology, seizure frequency, therapy assessed for patients. For each...