A5026161094- Cholesterol and Lipid Metabolism
- Genetics and Neurodevelopmental Disorders
- Effects and risks of endocrine disrupting chemicals
- Lipid metabolism and biosynthesis
- Biochemical Analysis and Sensing Techniques
- Diet, Metabolism, and Disease
- HIV Research and Treatment
- Autoimmune and Inflammatory Disorders Research
- Ubiquitin and proteasome pathways
- Biochemical effects in animals
- Adipose Tissue and Metabolism
- Lysosomal Storage Disorders Research
- Fatty Acid Research and Health
- Child Nutrition and Water Access
- Alkaloids: synthesis and pharmacology
- Environmental and biological studies
- Nuclear Receptors and Signaling
- Nerve injury and regeneration
- Monoclonal and Polyclonal Antibodies Research
- Multiple Myeloma Research and Treatments
- Diet and metabolism studies
- Academic Research in Diverse Fields
- Attention Deficit Hyperactivity Disorder
- Protein Degradation and Inhibitors
- Muscle Physiology and Disorders
Roma Tre University
2018-2025
Inborn errors of lysosomal function often provoke disorders presenting highly variable onset, diverse visceral, neurologic and psychiatric symptoms reduced life spans. A prime example is Niemann-Pick type C disease (NPCD). At present, therapeutic options are limited to palliative care disease-modifying drugs, there a need for new treatments. Here, we explored bromodomain extra-terminal domain (BET) proteins as drug target NPCD using patient-derived skin fibroblasts. Treatment cells with JQ1,...
The homeostatic control of lipid metabolism is essential for many fundamental physiological processes. A deep understanding its regulatory mechanisms pivotal to unravel prospective physiopathological factors and identify novel molecular targets that could be employed design promising therapies in the management disorders. Here, we investigated role bromodomain extraterminal domain (BET) proteins regulation metabolism. To reach this aim, used a loss-of-function approach by treating HepG2...
Bisphenol A (BPA) is an organic chemical compound widely used for manufacturing plastics. BPA exposure originates principally from the diet, but it can also originate dermal contact. In over 90% of individuals, including pregnant women, detectable in several body fluids. The effects this on fetus are under active investigation research laboratories. aim our work was to study impact prenatal liver rat fetuses a sex-dependent point view. We particularly investigated hepatic lipids because...
Fragile X Syndrome (FXS) is the most frequent form of inherited X-linked pathology, associated with an intellectual and developmental disability, currently considered first monogenic cause autism spectrum disorder (ASD). Low levels total cholesterol reported in serum FXS patients, evidence that FMRP targets a subset mRNAs encoding proteins lipid synthesis transport suggests metabolism impairments could be involved FXS. Thus, aim presented work was to investigate modulations biosynthetic...
Bisphenol A (BPA) is a synthetic compound widely used for the production of polycarbonate plasticware and epoxy resins. BPA exposure widespread more than 90% individuals have detectable amounts molecule in their body fluids, which originates primarily from diet. Here, we investigated whether prenatal to affects mevalonate (MVA) pathway rat brain fetuses, potential effects are sex-dependent. The MVA important development function. Our results demonstrate that fetal brain, exposed utero very...
Scope Cholesterol homeostasis is crucial for brain functioning. Unhealthy nutrition can influence cerebral physiology, but the effect of western diets on cholesterol homeostasis, particularly at middle age, unknown. Given link between alteration and beta amyloid production, aim to evaluate whether a diet rich in fat fructose affects protein network implicated synthesis shuttling glial cells neurons, as well markers metabolism. Methods results Middle aged rats are fed high fat–high (HFF) or...
Abstract Here, we investigated the protein network regulating cholesterol metabolism in liver and brain of adolescent adult male female rats prenatally exposed to valproate (VPA), a well validated experimental model autism spectrum disorders (ASD). We were aimed at studying whether prenatal VPA exposure affected proteins involved homeostasis sex‐dependent manner. To this aim metabolism, term synthesis plasma membrane trafficking, was analyzed by western blot different areas (amygdala,...
Despite its undisputable role in the homeostatic regulation of nervous system, nerve growth factor (NGF) also governs relevant cellular processes other tissues and organs. In this study, we aimed at assessing expression putative involvement NGF signaling skeletal muscle physiology. To reach objective, employed satellite cell-derived myoblasts as an vitro culture model. vivo experiments were performed on Tibialis anterior from wild-type mice mdx mouse model Duchenne muscular dystrophy....
Objective: We were aimed at evaluating the long-term impact of perinatal an omega-3 fatty acid-enriched diet on mevalonate/cholesterol pathway in brain male offspring.Methods: Female rats fed with standard or during pregnancy and lactation. Liver, plasma collected from infant, adolescent adult offspring for subsequent biochemical morphological analyses.Results: The enriched induced region-dependent changes 3-hydroxy 3-methylglutaryl Coenzyme A reductase affected notably RhoA/CREB signaling...
The detrimental impact of fructose, a widely used sweetener in industrial foods, was previously evidenced on various brain regions. Although adolescents are among the highest consumers sweet whether alterations induced by sugar intake during this age persist until young adulthood or rescued returning to healthy diet remains largely unexplored. To shed light issue, just weaned rats were fed with fructose-rich control for 3 weeks. At end treatment, fructose-fed underwent further weeks phase...
ABSTRACT Extensive research has focused on cellular cholesterol and its regulation, primarily due to crucial physiological roles association with numerous diseases resulting from dysregulated homeostasis. Consequently, investigating metabolism the network of regulating proteins remains an ongoing challenge for biomedical seeking new molecular targets manage aberrant levels in pathologic conditions. There is evidence that Sigma‐2/TMEM97 receptor regulates metabolism. However, mechanisms...
Background: A major problem of aging is the disruption metabolic homeostasis. This particularly relevant in brain where it provokes neurodegeneration. Caloric restriction a physiologic intervention known to delay deleterious consequences several species ranging from yeast mammals. To date, most studies on experimental models have started this dietary weaning, which very difficult be translated human beings. Here, we study effects more realistic regimen rats, starting at an advanced age and...
<h3>Background</h3> Effective cancer immunotherapy is driven by robust T cell response against neoantigens. A sufficient number of neoantigens crucial to stimulate at least 2–3 cancer-specific responses that can home into the tumor microenvironment and exert therapeutic activity. Current clinical trials support these principles, showing promising results with combinations approved immunotherapies, including anti-PD1 antibodies. Actually, most existing delivery systems for rely on...
Abstract The detrimental impact of fructose, a widely used sweetener in industrial foods, was previously evidenced on various brain regions. Although adolescents are among the highest consumers sweet whether alterations induced by sugar intake during this age persist until young adulthood or rescued returning to healthy diet remains largely unexplored. To shed light issue, adolescent rats were fed with fructose-rich control for 3 weeks. At end treatment, fructose-fed underwent further weeks...
Abstract Niemann-Pick type C disease (NPCD) is a lysosomal disorder whith patients presenting highly variable onset, neurovisceral symptoms and life spans due to defective lipid homeostasis. At present, therapeutic options are limited palliative disease-modifying drugs, there continued need for new approaches. Here, we explored bromodomain extraterminal (BET) proteins as drug target NPCD using patient-derived fibroblasts. Treatment of cells with JQ1, prototype BET inhibitor, enhanced the...