A5052255766- Nanoparticle-Based Drug Delivery
- Hydrogels: synthesis, properties, applications
- 3D Printing in Biomedical Research
- Supramolecular Self-Assembly in Materials
- Electrospun Nanofibers in Biomedical Applications
- Nanoparticles: synthesis and applications
- Heavy Metal Exposure and Toxicity
- Gold and Silver Nanoparticles Synthesis and Applications
- Advanced Drug Delivery Systems
- Innovative Microfluidic and Catalytic Techniques Innovation
- Chemical Synthesis and Analysis
- Microfluidic and Capillary Electrophoresis Applications
- Graphene and Nanomaterials Applications
- biodegradable polymer synthesis and properties
- Advanced Polymer Synthesis and Characterization
- Tissue Engineering and Regenerative Medicine
- Bone Tissue Engineering Materials
- Healthcare and Environmental Waste Management
- Polymer Surface Interaction Studies
- RNA Interference and Gene Delivery
- Advanced Radiotherapy Techniques
- Advanced MRI Techniques and Applications
- Nanopore and Nanochannel Transport Studies
- Polydiacetylene-based materials and applications
- Radiation Dose and Imaging
University of Milan
2018-2021
Institute for Microelectronics and Microsystems
2021
Interface (United States)
2020
Mylan (South Africa)
2020
Fondazione Filarete
2012-2018
Mylan (Switzerland)
2016
Milano University Press
2016
Istituto Nanoscienze
2009-2010
University of Salento
2009-2010
Silver nanoparticles (AgNPs) are an important class of nanomaterials used as antimicrobial agents for a wide range medical and industrial applications. However toxicity AgNPs impact their physicochemical characteristics in vivo models still need to be comprehensively characterized. The aim this study was investigate the effect size coating on tissue distribution after intravenous administration mice, compare results with those obtained silver acetate administration. Male CD-1(ICR) mice were...
The combination of materials that possess different properties (such as, for instance, fluorescence and magnetism) into one single object nanoscale size represents an attractive challenge biotechnology, especially their potential relevance in biomedical applications. We report here the preparation novel bifunctional conjugates based on linkage inorganic nanoparticles to organic oligothiophene fluorophores (OTFs). In comparison dyes commonly used bioimaging more similarly colloidal quantum...
Abstract Background Widespread use of silver in its different forms raises concerns about potential adverse effects after ingestion, the main exposure route for humans. The aim this study was to investigate CD-1 (ICR) male mice tissue distribution and vivo 4-week oral 0.25 1 mg Ag/kg bw 10 nm citrate coated nanoparticles (AgNPs) acetate (AgAc) at end treatment (EoT) 4 weeks recovery. Results There were no treatment-related clinical signs mortality, significant on body organ weights EoT...
The study of the mechanisms underlying uptake and release bioactive molecules from stimuli-responsive nanoparticles is key to their application in biomedical fields. Here, we present pH-controlled two chemically different solutes newly synthesized nanogels, showing potential as dual drug delivery systems. Nanogels were by emulsion copolymerization methacrylic acid (MAA) methyl acrylate (MA), then characterized FT-IR, 1H NMR, dynamic light scattering (DLS). To encapsulation properties...
Abstract The behavior of nanoparticles in biological systems is determined by their dimensions, size distribution, shape, surface chemistry, density, drug loading and stability; the characterization these parameters realistic conditions possibility to follow evolution vitro vivo are, most cases, far from capabilities standard technologies. Optical techniques such as dynamic light scattering (DLS) principle, well suited for line nanoparticle, however fail characterizing nanoparticle solution...
Abstract Nanometer‐sized poly(acrylic acid) (PAA) hydrogels were synthesized by emulsion polymerization of methyl acrylate and subsequent acidic hydrolysis. The nanohydrogel was characterized spectroscopic methods (FTIR 1 H‐NMR) scanning probe techniques, their pH‐dependent swelling behavior studied dynamic light scattering. To determine the suitability PAA nanogels as pH‐sensitive carriers for biomedical applications, uptake release an oligothiophene fluorophore its albumin conjugated from...
The exploitation of self-assembled systems to improve the solubility drugs is getting more and attention. Among different types biomaterials, peptides in particular containing non-coded amino acids (NCAPs) are promising because their use opens door stable materials inducing increased stability proteolysis. New classes NCAP, Ac-Ala-X-Ala-Aib-AlaCONH2 (X = alpha-aminoisobutyric acid (Aib) or X cyclopentane (Ac5c)) have been prepared correlation between secondary peptide structure solvent (i.e....
The preparation and self-assembly of short hydrophobic peptides containing the non-coded norbornene amino acid is reported. formation a supramolecular assembly in water was assessed by TEM DLS.
Abstract Summary: Nanometer‐sized poly(acrylic acid) (PAA) hydrogels were synthesized by emulsion polymerization of methyl acrylate and subsequent acid hydrolysis, their pH‐dependent swelling behaviour was studied dynamic light scattering. To determine the suitability PAA nanogels as pH‐sensitive carriers for biomedical applications, loading release an oligothiophene fluorophore its albumin conjugate onto investigated a function pH absorption photoluminescence measurements. It observed that...
Poly(d,l-lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) are among the most studied systems for drug and gene targeting. So far, synthesis of stable uniform PLGA NPs has involved use a large excess polyvinyl surfactants such as poly(vinyl alcohol) (PVA) polyvinylpyrrolidone (PVP), whose removal requires multistep purification procedures high ecological economic impact. Hence development environment-friendly cost-effective synthetic would effectively boost their in clinics. This work aims...
In this work, novel smart surfaces for in situcell staining were realized by covalent attachment of pH-responsive microgels on platforms dedicated to microfluidics lab-on-chip. The poly(methacrylic acid) firstly synthesized solution and then covalently immobilized a glass surface. As they preserve their pH-sensitive nature after the immobilization, loaded with an oligothiophene-conjugated anti-human CD4 monoclonal antibody, finally incubated Jurkat T-cell suspension. physiological pH...
Micropatterned collagen scaffold with axially oriented pores embedded poly(lactide-co-glycolide) nanoparticles (PLGA NPs) was synthesized and characterized. Two different concentrations of PLGA have been tested the experimental results indicate that concentration affects release kinetic, whereas stiffness, crosslink density, degradation rate matrix are comparable to bare scaffold. Further, proposed crosslinking procedure provides a resistance thermal enzymatic degradation, thereby promoting...
Herein proposed is a simple system to realize hands-free labeling and simultaneous detection of two human cell lines within microfluidic device. This was realized by novel covalent immobilization pH-responsive poly(methacrylic acid) microgels onto the inner glass surface an assembled polydimethylsiloxane/glass channel. Afterwards, selected thiophene labeled monoclonal antibodies, specific for recognition CD4 antigens on T helper/inducer cells CD19 B lymphocytes lines, were encapsulated in...
Abstract Poly(lactide‐ co ‐glycolide) ( PLGA ) nanoparticles NPs represent a promising tool for effective delivery of biomacromolecules, thanks to their biodegradability and biocompatibility properties. are often synthesized by the emulsion‐solvent evaporation method poly(vinyl alcohol) PVA represents one most commonly used surfactants. Although ‐mediated synthesis is in tailoring NP size stability, resulting negative surface charge can prevent both endosomal escape biomacromolecule release...
Increasing efforts have been focused on development of novel therapeutic approaches based a carrier mixed with polymeric microparticles (MPs) for promoting bioactive factors delivery. Polymers as poly (lactide-co-glycolide) are the most widely used due to their tunable physico-chemical properties and biomimetic character. Here, PLGA-MPs different surface charges were dispersed in hyaluronic acid impact viability four cell lines was studied. Our data reveal that evident effect is influence...