A5078153016- Synthesis and biological activity
- Computational Drug Discovery Methods
- Synthesis and Biological Evaluation
- Click Chemistry and Applications
- HIV/AIDS drug development and treatment
- Research on Leishmaniasis Studies
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- SARS-CoV-2 and COVID-19 Research
- Synthesis and Characterization of Heterocyclic Compounds
- Quinazolinone synthesis and applications
- Cancer therapeutics and mechanisms
- Tuberculosis Research and Epidemiology
- Synthesis and bioactivity of alkaloids
- HIV Research and Treatment
- Trypanosoma species research and implications
- Nanoparticle-Based Drug Delivery
- Phenothiazines and Benzothiazines Synthesis and Activities
- Bioactive Compounds and Antitumor Agents
- Multicomponent Synthesis of Heterocycles
- Cholinesterase and Neurodegenerative Diseases
- Synthesis of Organic Compounds
- Synthesis and Biological Activity
- Diverse Scientific Research Studies
- COVID-19 Clinical Research Studies
Birla Institute of Technology and Science, Pilani
2016-2025
Institut Teknologi dan Sains Mandala
2014-2025
Birla Institute of Technology, Mesra
2010-2024
Tamil Nadu Veterinary and Animal Sciences University
2023
Poultry Research Institute
2016-2020
Central Electrochemical Research Institute
2019
Bristol-Myers Squibb (United States)
2016
Bristol-Myers Squibb (India)
2016
Biocon (India)
2016
Syngene International (India)
2016
In the present study, an open-label, three-treatment, three-period clinical study of rosuvastatin (RSV) and rifampicin (RIF) when administered alone in combination was conducted 12 male healthy subjects to determine if coproporphyrin I (CP-I) III (CP-III) could serve as biomarkers for organic anion transporting polypeptide 1B1 (OATP1B1) 1B3 that belong solute carrier gene subfamily. Genotyping human OATP1B1 performed all confirmed absence OATP1B1*5 OATP1B1*15 mutations. Average plasma...
A new class of compounds formed by the linkage -C(O)-NH- with pyridine and thiazole moieties was designed, synthesized, characterized various spectral approaches. The newly were evaluated for their antimicrobial as well anti-inflammatory properties. in vitro activity these denaturation bovine serum albumin method showed inhibition range IC50 values-46.29-100.60 μg/mL. Among all tested compounds, compound 5l has highest value 5g least value. On other hand, results revealed that 5j lowest MIC...
COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily appeared in Wuhan, China, December 2019. At present, no proper therapy and vaccinations are available for the disease, it is increasing day with a high mortality rate. Pharmacophore based virtual screening of selected natural product databases followed Glide molecular docking dynamics studies against SARS-CoV-2 main protease was investigated to identify potential ligands that may act as inhibitors. The...
Abstract Spice-rich recipes are referred to as “functional foods” because they include a variety of bioactive chemicals that have health-promoting properties, in addition their nutritional value. Using pharmacoinformatics-based analysis, we explored the relevance found Rasam (a South Indian cuisine) against oxidative stress-induced human malignancies. The is composed twelve main ingredients, each which contains chemicals. Sixty-six compounds were from these and structures downloaded Pubchem....
The synthesis of copper nanoparticles (CuNPs) using Wrightia tinctoria (Wt) R.Br extract is defined in this article as being convenient, environmentally friendly, and non-toxic. UV-visible spectrophotometry, FT-IR, XRD, particle size analyser, SEM-EDAX TEM methods were used to describe the physicochemical properties Wt mediated synthesized CuNPs (Wt-CuNPs). Wt-CuNPs was found be monodispersed spherical, with an average 15 nm. Gas chromatography mass spectrometry (GC-MS) research revealed...
Lower doses of capsaicin (8-methyl-N-vanillyl-6-nonenamide) have the potential to serve as an anticancer drug, however, due its pungency, irritant effect, poor water solubility and high distribution volume often linked various off-target effects, therapeutic use is limited. This study aimed determine biodistribution efficacy loaded solid lipid nanoparticles (SLNs) in human hepatocellular carcinoma vitro. In this study, SLNs stearic acid with was formulated by solvent...
AbstractThe major enzyme responsible for the hydrolytic breakdown of neurotransmitter acetylcholine (ACh) is acetylcholinesterase (AChE). Acetylcholinesterase inhibitors (AChEIs) are most prescribed class medications treatment Alzheimer's disease (AD) and dementia. The limitations available therapy, like side effects, drug tolerance, inefficacy in halting progression, drive need better, more efficacious, safer drugs. In this study, a series fourteen novel chalcone-coumarin derivatives (8a-n)...
To discover anti-acetylcholinesterase agents for the treatment of Alzheimer's disease (AD), a series novel Schiff base-coumarin hybrids was rationally designed, synthesized successfully, and structurally characterized using Fourier transform infrared (FTIR), Nuclear magnetic resonance (NMR), High-Resolution Mass Spectrometry (HRMS) analyses. These were evaluated their potential inhibitory effect on acetylcholinesterase (AChE). All them exhibited excellent activity against AChE. The IC50...