A5089380977- Computational Drug Discovery Methods
- Synthesis and biological activity
- Nanoparticle-Based Drug Delivery
- Cholinesterase and Neurodegenerative Diseases
- Graphene and Nanomaterials Applications
- Synthesis and Characterization of Heterocyclic Compounds
- Phytochemicals and Antioxidant Activities
- Nanoparticles: synthesis and applications
- Nanoplatforms for cancer theranostics
- Alzheimer's disease research and treatments
- Synthesis and Biological Evaluation
- Medicinal Plants and Neuroprotection
- Retinoids in leukemia and cellular processes
- Pharmacological Effects of Natural Compounds
- RNA Interference and Gene Delivery
- Quinazolinone synthesis and applications
- Electrospun Nanofibers in Biomedical Applications
- Botanical Research and Applications
- Fungal Plant Pathogen Control
- Synthesis of Tetrazole Derivatives
- Diverse Scientific Research Studies
- Fungal Biology and Applications
- Click Chemistry and Applications
- Bioactive Compounds and Antitumor Agents
- Dyeing and Modifying Textile Fibers
M S Ramaiah University of Applied Sciences
2018-2025
Kalasalingam Academy of Research and Education
2023-2024
Al-Ameen College of Pharmacy
2017
Bharathiar University
2014
Periyar University
2014
Pondicherry University
2012
Kovai Medical Center and Hospital
2012
Research Institute of Health Sciences
2012
Abstract Spice-rich recipes are referred to as “functional foods” because they include a variety of bioactive chemicals that have health-promoting properties, in addition their nutritional value. Using pharmacoinformatics-based analysis, we explored the relevance found Rasam (a South Indian cuisine) against oxidative stress-induced human malignancies. The is composed twelve main ingredients, each which contains chemicals. Sixty-six compounds were from these and structures downloaded Pubchem....
The synthesis of copper nanoparticles (CuNPs) using Wrightia tinctoria (Wt) R.Br extract is defined in this article as being convenient, environmentally friendly, and non-toxic. UV-visible spectrophotometry, FT-IR, XRD, particle size analyser, SEM-EDAX TEM methods were used to describe the physicochemical properties Wt mediated synthesized CuNPs (Wt-CuNPs). Wt-CuNPs was found be monodispersed spherical, with an average 15 nm. Gas chromatography mass spectrometry (GC-MS) research revealed...
Plant materials are a rich source of polyphenolic compounds with interesting health-beneficial effects. The present study aimed to determine the optimized condition for maximum extraction polyphenols from grape seeds through RSM (response surface methodology), ANFIS (adaptive neuro-fuzzy inference system), and machine learning (ML) algorithm models. Effect five independent variables their ranges, particle size (X
Lower doses of capsaicin (8-methyl-N-vanillyl-6-nonenamide) have the potential to serve as an anticancer drug, however, due its pungency, irritant effect, poor water solubility and high distribution volume often linked various off-target effects, therapeutic use is limited. This study aimed determine biodistribution efficacy loaded solid lipid nanoparticles (SLNs) in human hepatocellular carcinoma vitro. In this study, SLNs stearic acid with was formulated by solvent...
Plants and their derived molecules have been traditionally used to manage numerous pathological complications, including male erectile dysfunction (ED). Mimosa pudica Linn. commonly referred as the touch-me-not plant, its extract are important sources of new lead in drug discovery research. The main goal this study was predict highly effective from M. for reaching maintaining penile erection before during sexual intercourse through silico molecular docking dynamics simulation tools. A total...
The present study investigated the antioxidant potential of aqueous methanolic extracts Hemidesmus indicus (L.) R.Br., followed by a pharmacoinformatics-based screening novel Keap1 protein inhibitors. Initially, this plant extract was assessed via assays (DPPH, ABTS radical scavenging, and FRAP). Furthermore, 69 phytocompounds in total were derived from using IMPPAT database, their three-dimensional structures obtained PubChem database. chosen docked against Kelch-Neh2 complex (PDB entry ID:...
Abstract: Breast cancer is a complex disease caused by the aberrant and unchecked proliferation of breast cells, which leads to development tumours. In various types cancer, Phosphoinositide 3- kinase/Protein kinase B (PKB, also known as Akt (PI3K/Akt) signalling pathway, essential for controlling cell survival, metastasis, metabolism. Currently, marketed PI3K inhibitors treating face several issues, including toxicity, resistance, etc. Significant efforts have been made develop synthetic...
Parkinson's disease (PD) is an advanced neurodegenerative condition distinguished by the rapid decline of dopamine neurons in midbrain, leading to imbalance and acetylcholine levels, precipitating associated symptoms. The main objective this work was fabricate solid lipid nanoparticles (SLNs) loaded with S-carboxymethyl-L-cystine (SC) for enhanced delivery brain. This study examines impact these SLNs on rotenone (RT) caused both rat zebrafish models. process loading SC into achieved through...
Targeted drug delivery systems are a promising field of research. Nano-engineered material-mediated possesses remarkable potential for the treatment various malignancies. Here, folic acid (FA)-conjugated bovine serum albumin (BSA) nanoparticles (NPs) were used to encapsulate myricetin (Myr). Subsequently, Myr via naturally overexpressed folate receptor (FR) FR-positive breast cancer cells was studied. Myr-loaded BSA NPs assembled by modified desolvation cross-linking technique. An...
Neglected tropical diseases (NTDs) afflict more than one billion peoples in the world’s poorest countries. The World Health Organization (WHO) has recorded seventeen NTDs its portfolio, mainly caused by bacterial, protozoal, parasitic, and viral infections. Each of unique challenges on human health such as interventions for control, prevention, diagnosis, treatment. Research development new drug molecules against not been undertaken pharmaceutical industries due to high investment...
Endophytic fungi are a diverse group of microorganisms that colonize the inter- or intracellular spaces plants and exhibit mutual benefits. Their interactions with host plant other microbiomes multidimensional play crucial role in production secondary metabolites. We screened bioactive compounds present extracts Aspergillus flavus, an endophytic fungus isolated from roots medicinal grass Cynodon dactylon, for its anticancer potential. An vitro analysis Ethyl acetate extract A. flavus showed...