A5113512431- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Crystallization and Solubility Studies
- Lanthanide and Transition Metal Complexes
- X-ray Diffraction in Crystallography
- Functional Brain Connectivity Studies
- Mitochondrial Function and Pathology
- Traumatic Brain Injury Research
- Nanoparticle-Based Drug Delivery
- Alzheimer's disease research and treatments
- Electron Spin Resonance Studies
- Click Chemistry and Applications
- Nanoplatforms for cancer theranostics
- Iron oxide chemistry and applications
- Angiogenesis and VEGF in Cancer
- Computational Drug Discovery Methods
- Traumatic Brain Injury and Neurovascular Disturbances
- Graphene and Nanomaterials Applications
- Neurological disorders and treatments
- Cholinesterase and Neurodegenerative Diseases
- Advanced Drug Delivery Systems
- Carbon Nanotubes in Composites
- Characterization and Applications of Magnetic Nanoparticles
- Genetic Neurodegenerative Diseases
- Medical Imaging Techniques and Applications
M S Ramaiah University of Applied Sciences
2024
Institute of Nuclear Medicine & Allied Sciences
2012-2018
O'Brien Institute
2008
The University of Melbourne
2008
Parkinson's disease (PD) is an advanced neurodegenerative condition distinguished by the rapid decline of dopamine neurons in midbrain, leading to imbalance and acetylcholine levels, precipitating associated symptoms. The main objective this work was fabricate solid lipid nanoparticles (SLNs) loaded with S-carboxymethyl-L-cystine (SC) for enhanced delivery brain. This study examines impact these SLNs on rotenone (RT) caused both rat zebrafish models. process loading SC into achieved through...
Synthesis of a contrast agent for biomedical imaging is great interest where magnetic nanoparticles are concerned, because the strong influence particle size on transverse relaxivity. In present study, biocompatible iron oxide were synthesized by co-precipitation Fe2+ and Fe3+ salts, followed surface adsorption with reduced dextran. The spherical in shape, 12 ± 2 nm as measured using transmission electron microscopy; this was corroborated results from X-ray diffraction dynamic light...
In the present study, engineered lactoferrin (Lf)-conjugated pH and redox-sensitive polymersomes derived from triblock copolymer polyethylene glycol-S-S-polylactic acid-polycaprolactone (PEG-S-S-PLA-PCL-OH) have been used to deliver bacosides brain.
Abstract The nuclear arsenal and the use of technologies have enhanced likelihood whole‐body/partial‐body radiation exposure. central nervous system is highly susceptible to even low doses radiation. With aim detecting monitoring pathologic changes radiation‐induced damage in brain parenchyma, we used serial diffusion tensor magnetic resonance imaging (DTI) with a 7T unit neurobehavioral assessments mice irradiated 3‐, 5‐, 8‐Gy Fractional anisotropy (FA) mean diffusivity (MD) values at each...
Abstract Using an in vivo arterio‐venous loop‐containing tissue‐engineering chamber, we have created a variety of vascularized tissue blocks, including functional myocardium. The viability the transplanted cells is limited by rate neovascularization chamber. A Nox2‐containing nicotinamide adenine dinucleotide phosphate (NADPH) oxidase thought to critical role ischaemic angiogenesis. In this study investigated whether NADPH involved process New blood vessels originating from venous and...
Ionizing radiation is known to a cause systemic inflammatory response within hours of exposure that may affect the central nervous system (CNS). The present study was carried out look upon influence induced in hippocampus 24 hr whole body exposure. A Diffusion Tensor Imaging (DTI) conducted mice exposed 5-Gy dose through 60 Co source operating at 2.496 Gy/min 3 and post irradiation sham-irradiated controls using 7 T animal MRI system. results showed significant decrease Mean Diffusivity...
Understanding early differential response of brain during whole body radiation or cranial exposure is significant importance for better injury management accidental intentional to ionizing radiation. We investigated the microstructural and metabolic profiles using in vivo diffusion tensor imaging (DTI) proton magnetic resonance spectroscopy ( 1 H MRS) following 8 Gy mice a 7.0 T animal MRI system compared with sham controls at days 1, 3, 5 10 post irradiation. A decrease fractional...
Purpose: In the classical description of acute radiation syndrome, role central nervous system (CNS) is underestimated. It now well recognised that ionising radiation-induced oxidative stress may bring about functional changes in brain. this study, we prospectively evaluated metabolic brain after whole body irradiation mice using vivo proton (1H) nuclear magnetic resonance spectroscopy (MRS).Material and methods: Young adult were exposed to 8 Gy controls sham irradiated. 1H MRS from...
Alzheimer's disease (AD) is a gradual degenerative ailment of the nervous system that marked by buildup amyloid-β plaques and neurofibrillary tangles. This accumulation causes problems with connections between nerve cells loss these cells. review paper explores complex pathophysiology AD, analyzing neuronal reported in key brain regions like entorhinal cortex, amygdala, hippocampus, cortical association areas. The text also examines subcortical nuclei participation, such as noradrenergic...
Abstract Rational design of a new class MR (magnetic resonance) contrast agent for enhance relaxivity has been described. The click chemistry was employed to incorporate two moieties 1‐(2‐methoxyphenyl)piperazine and serinol as linker the affinity at recognition sites. designed ligand attached DO3A synthesize DO3A‐serinol‐bis‐MPP (SBMPP) in 89 % yield. Gd‐DO3A‐SBMPP showed enhanced r 1 10.85±0.04 mM −1 s compare known gadolinium based agents clinics. potentiometric titration loaded SBMPP...