A5073604991- Synthesis and biological activity
- Synthesis and Biological Evaluation
- Quinazolinone synthesis and applications
- Protein Interaction Studies and Fluorescence Analysis
- Bioactive Compounds and Antitumor Agents
- Enzyme function and inhibition
- Metal complexes synthesis and properties
- Synthesis and Catalytic Reactions
- Cancer therapeutics and mechanisms
- Computational Drug Discovery Methods
- Phenothiazines and Benzothiazines Synthesis and Activities
- Cholinesterase and Neurodegenerative Diseases
- Hepatitis C virus research
- Synthesis and Characterization of Heterocyclic Compounds
- Advanced Breast Cancer Therapies
- DNA and Nucleic Acid Chemistry
- Drug Transport and Resistance Mechanisms
- Monoclonal and Polyclonal Antibodies Research
- Cancer Mechanisms and Therapy
- Click Chemistry and Applications
- Metabolism, Diabetes, and Cancer
- Lanthanide and Transition Metal Complexes
- HER2/EGFR in Cancer Research
- Nanoparticles: synthesis and applications
- Biochemical and Molecular Research
Ain Shams University
2025
Dar Al Uloom University
2025
King Saud University
2018-2023
Vascular endothelial growth factor receptor-2 (VEGFR-2) plays a critical role in cancer angiogenesis. Inhibition of VEGFR-2 activity proved effective suppression tumour propagation. Accordingly, two series new 3-methylquinoxaline derivatives have been designed and synthesised as inhibitors. The were evaluated vitro for their cytotoxic activities against MCF-7and HepG2 cell lines. In addition, the inhibitory target compounds estimated to indicate potential mechanism cytotoxicity. To great...
A new series of 3-methylquinoxaline-based derivatives having the same essential pharmacophoric features as VEGFR-2 inhibitors have been synthesized and evaluated for their antiproliferative activities against two human cancer cell lines, MCF-7 HepG-2. Compounds 15b 17b demonstrated a significant effect with IC50 ranging from 2.3 to 5.8 μM. An enzymatic assay was carried out all tested candidates VEGFR-2. Compound most potent inhibitor (IC50 = 2.7 nM). Mechanistic investigation including...
Quetiapine (QTP) is a short-acting atypical antipsychotic drug that treats schizophrenia or manic episodes of bipolar disorder. Human serum albumin (HSA) an essential transport protein transports hormones and various other ligands to their intended site action. The interactions QTP with HSA binding mechanism in the HSA-QTP system was studied using spectroscopic molecular docking techniques. UV-Vis absorption study shows hyperchromicity spectra on addition QTP, suggesting complex formation...
The interaction between erlotinib (ERL) and bovine serum albumin (BSA) was studied in the presence of quercetin (QUR), a flavonoid with antioxidant properties. Ligands bind to transport protein BSA resulting competition different ligands displacing bound ligand, higher plasma concentrations. Therefore, various spectroscopic experiments were conducted addition silico studies evaluate behavior BSA-ERL system absence QUR. quenching curve binding constants values suggest QUR ERL BSA. constant...
Alzheimer's disease (AD) is a progressive neurological illness that distinguished clinically by cognitive and memory decline adversely affects the people of old age. The treatments for this gained much attention have prompted increased interest among researchers in field. As springboard to explore new anti-Alzheimer's chemical prototypes, present study was carried out synthesis benzoxazole-oxadiazole analogues as effective inhibitors. In research work, we focused our efforts synthesize...
Herein, a new wave of bis([1, 2, 4]triazolo)[4,3-a:3',4'-c]quinoxaline derivatives have been successfully designed and synthesised. The synthesised were biologically investigated for their cytotoxic activities against HepG2 MCF-7. Also, the tested compounds further examined in vitro VEGFR-2 inhibitory activity. most promising derivative 23j was its apoptotic behaviour cell lines using flow cytometric western-plot analyses. Additional in-silico studies performed to predict how can bind...
There is an urgent need to design new anticancer agents that can prevent cancer cell proliferation even with minimal side effects. Accordingly, two series of 3-methylquinoxalin-2(1H)-one and 3-methylquinoxaline-2-thiol derivatives were designed act as VEGFR-2 inhibitors. The synthesised evaluated in vitro cytotoxic against human lines namely, HepG-2 MCF-7. Also, the assessed for their VEGFR-2inhibitory effect. most promising member 11e further investigated reach a valuable insight about its...
In the field of nano-biotechnology, silver nanoparticles (AgNPs) share a status high repute owing to their remarkable medicinal values. Biological synthesis environment-friendly AgNPs using plant extracts has emerged as beneficial alternative approach chemical synthesis. current study, we have synthesized biogenic (PG-AgNPs) peel extract
A synthesized and promising biologically hypoglycemic compound 5,6-Dichloro-2-[2-(pyridin-2-yl)ethyl]isoindoline-1,3-dione ( 5e ) was studied for its binding to a model protein (bovine serum albumin; BSA) by spectroscopic molecular simulation approaches. Fluorescence studies revealed that quenched BSA's intrinsic fluorescence static quenching. The experiments were performed at three different temperatures the quenching constants evaluated. Stern-Volmer constant (K sv values decreased from...
Dapoxetine is a selective serotonin reuptake inhibitor, used to treat premature ejaculation in men.Dapoxetine may interact with the DNA and hence this study investigated dapoxetine calf thymus (ctDNA) binding interaction.The interaction of ligands importance development molecular probes therapeutic agents.Spectroscopic techniques including spectrofluorometry spectrophotometry were employed interaction.Fluorescence studies indicated static quenching mechanism between ctDNA.Groove was...
Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), resulting in a contagious tract infection that has become global burden since the end of 2019. Notably, fewer patients infected with SARS-CoV-2 progress from onset to death compared progression rate associated two other coronaviruses, SARS-CoV and Middle East (MERS-CoV). Several research organizations pharmaceutical industries have attempted develop successful vaccine candidates for...
A series of 12 compounds was designed and synthesized, based on 2-mercaptobenzoxazole derivatives containing either the substituted benzenes 4a-d, isatins 5a-f, or heterocycles 6a-b. The in vitro antiproliferative activity evaluated against hepatocellular carcinoma (HepG2), mammary gland cancer (MCF-7), breast (MDA-MB-231), epithelioid cervix (HeLa) cell lines. Compounds 4b, 4d, 5d, 6b had most potent activity, with IC50 values ranging from 2.14 to 19.34 µM, compared reference drugs,...
Nine N-alkylated phenytoin derivatives (5-13) have been synthesized and characterized using spectroscopic tools with the structures of 4-6 confirmed by X-ray crystallography. The starting material, 2, was obtained a base-catalyzed condensation from benzyl urea. Its alkylation chloride yields 3 4. Subsequently, various alkyl halides under solid-liquid phase transfer catalysis (PTC) led to formation 5-13. intercontacts in crystals are identified analyzing their corresponding Hirshfeld surfaces...