Abstract Seven chalcone derivatives were synthesized by the Claisen-Schmidt condensation. The structures of compounds confirmed spectral data (Ultraviolet/visible, infrared, nuclear magnetic resonance and mass spectroscopy). tested for their in silico vitro antimicrobial antioxidant activities. molecular docking assessments showed that all exhibited good binding affinity with target microorganism proteins but, 6e 6g better compared standards. test revealed screened active against S...

Twelve new derivatives of benzothiazole bearing benzenesulphonamide and carboxamide were synthesised investigated for their in vivo anti-inflammatory, analgesic ulcerogenic activities. Molecular docking showed an excellent binding interaction the compounds with receptors, 17c showing highest energy (-12.50 kcal/mol). Compounds 17i inhibited carrageenan-induced rat paw oedema at 72, 76, 80% 64, 73, 78% 1 h, 2 3 respectively. In activity experiment, 17c, 17 g, had ED50 (µM/kg) 96, 127, 84...

Abstract A new series of novel dipeptide sulfonamide analogues were designed, synthesized, and screened for their in silico studies vivo antimalarial activities. The synthesized compounds (50 mg/Kg) showed significant activity against P. berghei (NK65) with % inhibition values (5.9 to 64.7 %) range when compared reference drug, artemisinin (66.7 a four day suppressive assay. predicted favorable binding affinity target protein residues high dock score falciparum falcipain 2 (FP‐2) 3 (FP‐3)...

Sulfonamide-based carboxamide drugs have multiple active sites that confers them with a variety of chemical and pharmacological activities. The combination structural functionalities has been established to be vital in the drug discovery process. synthesis novel, nontoxic, cheap effective anti-parasitic analogues is trending aspect pharmaceutical medicinal chemistry research. In this research, synthesis, characterization, density functional theory (DFT) investigation reactivity...

Water pollution is responsible for over 1.8 million global death annually. Among the water pollutants are heavy metals including chromium, nickel, copper, arsenic, mercury, and lead. Interestingly, some of cobalt, iron, zinc, manganese components important biological enzymes involved in redox reactions body. However, transitions between various oxidation states these essential sources free radicals leading to oxidative stress. Adsorption has been a well-researched means removing metal...

Background: Cardiovascular disease (CVD) is a major global health challenge, influenced by various demographic, socioeconomic, and lifestyle factors. Understanding the role of modifiable risk factors crucial for developing targeted public interventions. This study investigates predictors CVD using data from Behavioral Risk Factor Surveillance System (BRFSS), with focus on identifying high-risk populations key contributors. Methods: A generalized linear model (GLM) logit link was applied to...

A series of nine substituted derivatives 4‐methyl‐2‐(3‐methyl‐2‐(4‐methylphenylsulfonamido)‐butanamido)thiazole‐5‐carboxylate were synthesized, characterized, and evaluated for antimalarial activity. The synthesis involved a two‐step process using methyl acetoacetate various benzenesulfonamoyl alkanamides. Structural confirmation was achieved NMR mass spectroscopy. in vivo efficacy tested against Plasmodium berghei Swiss albino mice, with artemisinin as the reference drug. Compounds 4e 4h...

The detection and response to infectious disease outbreaks remain a crucial global public health challenge because these produce substantial difficulties for authorities. study summarizes recent research about outbreak management techniques through discussions of efficient surveillance programs control measures along with community participation. Study results show that suffers setbacks due restricted funding challenges in data exchange compliance from the population, mostly affecting...

This literature review examines the multifaceted challenges and strategies related to health equity within public initiatives. It highlights critical importance of addressing structural barriers historical injustices perpetuating disparities among marginalized communities. Key for improving equity, such as community-led approaches, place-based initiatives, workforce development, data-driven management, equitable financial systems, are analyzed through lens successful programs like STRETCH...

Bacterial resistance to antibiotics over the past few decades has become one of most challenging problems infectious treatment. Sulphonamides and carboxamides have shown quite a number pharmacological properties against different types diseases among which is microbial infection. Ten new derivatives benzenesulphonamide bearing carboxamide functionality were synthesized investigated for their in vivo anti-inflammatory, vitro anti-microbial anti-oxidant activities. The base promoted reactions...

Self-assembly is the organization of molecular units into ordered structures using non-covalent interactions like hydrogen bonding, Van der Waals forces, π-π stacking, capillarity, entropy, and others. The most widely reported in self-assembly are bonding stacking interactions. can be employed synthesis bidentate ligands their complexes bond interaction monodentate ligands. These self-assembled metal have found applications hydrogenation, hydroformylation, hydrocyanation, hydration reactions...

Experimental and theoretical investigation of the anti-hypertensive activity novel 2-[N-(4-methylbenzenesulfonyl)-1-phenylformamido]-N-(4-nitrophenyl)-3-phenylpropenamide (MBPNPP) was carried out. The experimental approach followed dietary induction spontaneously hypertensive adult male Wistar rats (SHRs) using 66% w/v D-fructose angiotensin I-converting enzyme (ACE) inhibitory assay while study achieved DFT calculations molecular docking against hypertension responsive proteins....

Pyrimidines, sulphonamides and carboxamides have shown a large number of pharmacological properties against different types diseases including helminthiasis. Seventeen new pyrimidine derivatives bearing sulphonamide carboxamide were synthesized investigated for their in vitro anthelmintic properties. Substituted benzenesulphonyl chlorides 15a?c treated with various amino acids (16a?h) to obtain benzenesulphonamide 17a?l. Compounds 17a?f subsequently benzoyl chloride the N-benzoylated 19a?f....

The study aimed to investigate novel pyrrolidine-pentanamide derivatives of sulfonamides as potential anti-malaria agents through a comprehensive approach involving experimental, theoretical, and in silico evaluations. compounds were synthesized using standard methods characterized NMR, FT-IR, HRMS techniques. molecular properties the investigated density functional theory (DFT) at B3LYP-D3 meta-functional/GenECP theoretical level. calculated vibrational frequencies showed good agreement...

The successful nickel catalyzed synthesis of N-(aryl) substituted p-toluene sulphonamides is reported. intermediate 4-methylbenzenesulphonamide was obtained by the reaction p-toluenesulphonyl chloride and ammonium hydroxide. Substituted were coupling with readily available aryl halides via Buchwald-Hartwig cross-coupling reaction. structures compounds confirmed using Fourier Transform Infrared (FT-IR), proton NMR, carbon-13 NMR mass spectroscopy. new screened for antibacterial antifungal...

Fourteen novel dipeptide carboxamide derivatives bearing benzensulphonamoyl propanamide were synthesized and characterized using 1H NMR, 13C FTIR MS spectroscopic techniques. In vivo antimalarial in vitro antimicrobial studies carried out on these compounds. Molecular docking, haematological analysis, liver kidney function tests also evaluated to assess the effect of compounds organs. At 200 mg/kg body weight, 7i inhibited multiplication parasite by 81.38% day 12 post-treatment exposure....