A5070731204- Aquatic Ecosystems and Phytoplankton Dynamics
- Algal biology and biofuel production
- Biocrusts and Microbial Ecology
- Chemical synthesis and alkaloids
- Computational Drug Discovery Methods
- Malaria Research and Control
- Plant tissue culture and regeneration
- Quinazolinone synthesis and applications
- Phytochemical compounds biological activities
- Biochemical and Structural Characterization
- Metabolomics and Mass Spectrometry Studies
- Synthesis and biological activity
- Synthesis and Characterization of Heterocyclic Compounds
Universidad de la República
2021-2024
The synthesis of cyclotetrapeptides analogues the natural products tentoxin and versicotide D was achieved in good yield by solid phase peptide (SPPS) their linear precursors solution cyclization. All cyclopeptides several open were evaluated as herbicides. Five five lineal peptides showed a significant inhibition (>70%) Ryegrass seed’s radicle growth at 67 μg/mL. evaluation lower concentrations (4−11 μM) indicates two analogs tentoxin, which present one (N-Methyl-d-Phe), N-MeAA...
Natural products derived from plants or microorganisms have been considered as eco-friendly herbicides with application in crop protection. Several natural cyclopeptides reported herbicides, while others identified inhibitors of cyanobacteria. In this work, the syntheses cyclotetrapeptides and cyclopentapeptides analogues were successfully performed by solid-phase peptide synthesis their linear precursor solution-phase macrolactamization. Four obtained peptides present phytotoxicity more...
The syntheses of cyclotetrapeptides and cyclopentapeptides analogues natural products were successfully performed by SPPS their linear precursor solution phase macrolactamization. Four the obtained peptides cyclopeptides present phytotoxicity with more than 70% radicle growth inhibition at 67 μg/mL. In addition, evaluation 20 cyclopeptides, as inhibitors cyanobacteria rendered five active compounds that reduced concentration mycrocistins in culture medium 40
Abstract During the last years, progression to control malaria disease seems be slowed and WHO (World Health Organization) reported a modelling analysis with prediction of increase in morbidity mortality sub-Saharan Africa during COVID-19 pandemic. A rapid way discovery new drugs could carried out by performing investigations identify based on repurposing “old” drugs. The 5-nitrothiazole drug, Nitazoxanide was shown active against intestinal protozoa, human helminths, anaerobic bacteria,...