A5021503947- Chemical Synthesis and Analysis
- Synthesis and biological activity
- Synthesis and Biological Evaluation
- Trypanosoma species research and implications
- Asymmetric Synthesis and Catalysis
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Synthesis and Catalytic Reactions
- Synthesis and Characterization of Heterocyclic Compounds
- Research on Leishmaniasis Studies
- Synthetic Organic Chemistry Methods
- Bioactive Compounds and Antitumor Agents
- Synthesis and Reactions of Organic Compounds
- Marine Sponges and Natural Products
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Phytochemical compounds biological activities
- Quinazolinone synthesis and applications
- Synthesis of heterocyclic compounds
- Algal biology and biofuel production
- Metal complexes synthesis and properties
- Marine Toxins and Detection Methods
- Vanadium and Halogenation Chemistry
- Aquatic Ecosystems and Phytoplankton Dynamics
- Chemical synthesis and alkaloids
- Multicomponent Synthesis of Heterocycles
Universidad de la República
2013-2024
Rede de Química e Tecnologia
2012-2014
Universidad La República
2012-2014
Centro Uruguayo de Imagenología Molecular
1997-2013
Universidad de Montevideo
2006
University of Pittsburgh
2005
Development of a 99m Tc‐labelled glucose derivative as single‐photon emission computed tomography analogue to [ 18 F]‐2‐fluoro‐2‐deoxy‐D‐glucose (FDG) is considered great interest. Herein, we present the synthesis and preliminary bioevaluation Tc(CO) 3 ‐glucose derivative. Derivatization at C2 was achieved using so‐called ‘click chemistry’, forming histidine‐like, 1,4‐disubstituted triazole adequate donor atom system for Tc(I)‐tricarbonyl complexes. Synthesis intermediate azide by...
Introduction: The identification of chemical compounds that interfere with SARS-CoV-2 replication continues to be a priority in several academic and pharmaceutical laboratories. Computational tools approaches have the power integrate, process analyze multiple data short time. However, these initiatives may yield unrealistic results if applied models are not inferred from reliable resulting predictions confirmed by experimental evidence. Methods: We undertook drug discovery campaign against...
Macrocycle analogs and key fragments of aerucyclamides were obtained evaluated against <italic>Trypanosoma brucei brucei</italic>.
Azolic and non-azolic cyclohexapeptides were obtained and/or evaluated as promising antimalarial anti-trypanosomal agents.
Malaria is a major tropical disease where important needs are to mitigate symptoms and prevent the establishment of infection. Cyclopeptides containing N-methyl amino acids with in vitro activity against erythrocytic forms as well liver stage presented. The synthesis, parasitological characterization, physicochemical properties, vivo evaluation, mice pharmacokinetics described.
Using different heterocycle formation methodologies (Deoxo-Fluor, DAST, POCl3, TosMIC), [2,5]bis-1,3- azoles were prepared as stable analogs of bengazoles, a family potent anthelmintic marine natural products. The cytotoxic activity these heterocycles and their precursors on HCT-15 cells the effect L4 larvae Nippostrongylus brasiliensis evaluated. Keywords: Bis-1, 3-azoles, Anthelmintic, Cytotoxic, Bengazoles
Double cyclizations to bis-thiazolines have been performed using the Deoxo-Fluor cyclodehydration agent.Some limitations of use for synthesis oxazolines are described.Bis-thiazoles, bis-oxazoles and oxazole-thiazole systems found in numerous interesting biologically active natural products such: cystothiazoles, myxothiazoles, diazonamide bengazoles. 1
The synthesis of cyclotetrapeptides analogues the natural products tentoxin and versicotide D was achieved in good yield by solid phase peptide (SPPS) their linear precursors solution cyclization. All cyclopeptides several open were evaluated as herbicides. Five five lineal peptides showed a significant inhibition (>70%) Ryegrass seed’s radicle growth at 67 μg/mL. evaluation lower concentrations (4−11 μM) indicates two analogs tentoxin, which present one (N-Methyl-d-Phe), N-MeAA...
Tandem cyclizations to [2,5] bis-1,3-azoles provided simplified and stable models of biological active marine natural products. The cytotoxic activity in HCT-15 cells the effect on L4 larvae Nippostrongylus brasiliensis heterocycles were evaluated data that serve for preparation bioselective new therapeutic agents. Keywords: Bis-1,3-azoles, anthelmintic, cytotoxic, Bengazoles
Reaction of allyltriphenylphosphonium bromide and Garners aldehyde in basic media provided β- hydroxy-1,3-dienes. Similar results are described for other aliphatic aromatic aldehydes. Keywords: β-hydroxy-1, 3-diene, Garner's aldehyde, Wittig reactions,
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of Albendazole Metabolite: Characterization and HPLC DeterminationGraciela Mahler , Danilo Davyt Sandra Gordon Marcelo Incerti Ivana Núñez Horacio Pezaroglo Laura Scarone Gloria Serra Mauricio Silvera Eduardo Manta View Author Information Departamento de Química Orgánica, Cátedra Farmacéutica Facultad Química, Universidad la República, Montevideo, UruguayCite this: J. Chem. Educ. 2008, 85, 12, 1652Publication Date (Web):December 1,...
We present a concise and high-yielding route for the preparation of novel five-, six-, seven-membered cycloether systems bearing [2,4]-oxazoles units.The approach is based on intramolecular electrophilic oxirane ring expansion strategies β-hydroxyamide cyclodehydration-oxidation reactions mediated by Deoxo-Fluor BrCCl 3 /DBU.HETEROCYCLES, Vol.75, No. 6, 2008 1385which have inspired widespread interest among synthetic community led to nine published total syntheses date.
Natural products derived from plants or microorganisms have been considered as eco-friendly herbicides with application in crop protection. Several natural cyclopeptides reported herbicides, while others identified inhibitors of cyanobacteria. In this work, the syntheses cyclotetrapeptides and cyclopentapeptides analogues were successfully performed by solid-phase peptide synthesis their linear precursor solution-phase macrolactamization. Four obtained peptides present phytotoxicity more...