A5035580410- Chemical synthesis and alkaloids
- Aquatic Ecosystems and Phytoplankton Dynamics
- Algal biology and biofuel production
- Agronomic Practices and Intercropping Systems
- Fungal Biology and Applications
- Biocrusts and Microbial Ecology
- Weed Control and Herbicide Applications
- Biochemical and Structural Characterization
- Phytochemical compounds biological activities
- Allelopathy and phytotoxic interactions
- Plant tissue culture and regeneration
- Microbial Natural Products and Biosynthesis
Universidad de la República
2022-2024
Abstract The first total synthesis of cyclopeptides versicotide E and F, natural products produced by marine fungus Aspergillus versicolor LZD‐14‐1 , was achieved in good yield solid phase peptide (SPPS) their linear precursors solution cyclization. All the versicotides A−F were evaluated as herbicides inhibitors cyanobacterial growth. Versicotides A, B, D, F showed a significant inhibition Rye grass seed's radicle growth at concentration 67 μg/mL. B D also inhibited seed germination leaf...
The synthesis of cyclotetrapeptides analogues the natural products tentoxin and versicotide D was achieved in good yield by solid phase peptide (SPPS) their linear precursors solution cyclization. All cyclopeptides several open were evaluated as herbicides. Five five lineal peptides showed a significant inhibition (>70%) Ryegrass seed’s radicle growth at 67 μg/mL. evaluation lower concentrations (4−11 μM) indicates two analogs tentoxin, which present one (N-Methyl-d-Phe), N-MeAA...
Natural products derived from plants or microorganisms have been considered as eco-friendly herbicides with application in crop protection. Several natural cyclopeptides reported herbicides, while others identified inhibitors of cyanobacteria. In this work, the syntheses cyclotetrapeptides and cyclopentapeptides analogues were successfully performed by solid-phase peptide synthesis their linear precursor solution-phase macrolactamization. Four obtained peptides present phytotoxicity more...
The syntheses of cyclotetrapeptides and cyclopentapeptides analogues natural products were successfully performed by SPPS their linear precursor solution phase macrolactamization. Four the obtained peptides cyclopeptides present phytotoxicity with more than 70% radicle growth inhibition at 67 μg/mL. In addition, evaluation 20 cyclopeptides, as inhibitors cyanobacteria rendered five active compounds that reduced concentration mycrocistins in culture medium 40