A5091603992- Synthesis and biological activity
- vaccines and immunoinformatics approaches
- Computational Drug Discovery Methods
- Click Chemistry and Applications
- Rabbits: Nutrition, Reproduction, Health
- Viral Infectious Diseases and Gene Expression in Insects
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- SARS-CoV-2 and COVID-19 Research
- CRISPR and Genetic Engineering
- Synthesis and Reactivity of Heterocycles
- Insects and Parasite Interactions
- Helminth infection and control
- Insect Resistance and Genetics
National University of the Littoral
2017-2023
Institut Pasteur de Montevideo
2022-2023
Introduction: The identification of chemical compounds that interfere with SARS-CoV-2 replication continues to be a priority in several academic and pharmaceutical laboratories. Computational tools approaches have the power integrate, process analyze multiple data short time. However, these initiatives may yield unrealistic results if applied models are not inferred from reliable resulting predictions confirmed by experimental evidence. Methods: We undertook drug discovery campaign against...
The COVID-19 pandemic prompted several drug repositioning initiatives with the aim to rapidly deliver pharmacological candidates able reduce SARS-CoV-2 dissemination and mortality. A major issue shared by many of in silico studies addressing discovery compounds or drugs targeting molecules is that they lacked experimental validation results. Here we present a computer-aided drug-repositioning campaign against indispensable main protease (MPro 3CLPro) involved development ligand-based...
Fil: Ruatta, Santiago Matias. Universidad Nacional del Litoral. Facultad de Bioquimica y Ciencias Biologicas; Argentina.