The preparation of N-methylpyrazoles is usually accomplished through reaction a suitable 1,3-diketone with methylhydrazine in ethanol as the solvent. This strategy, however, leads to formation regioisomeric mixtures N-methylpyrazoles, which sometimes are difficult separate. We have determined that use fluorinated alcohols such 2,2,2-trifluoroethanol (TFE) and 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) solvents dramatically increases regioselectivity pyrazole formation, we used this...

A small library of compounds with an oxa(thia)zole scaffold and structural diversity in both positions 2 5 has been synthesized. Double acylation a protected glycine affords intermediate α-amido-β-ketoesters, which turn can be dehydrated to afford 1,3-oxazoles or reacted Lawesson's reagent furnish 1,3-thiazoles. This procedure was designed its adaptation fluorous techniques mind. Thus, when tag the ester moiety is used as starting material, synthesis easily completed without column...

The use of bis(pyridine)iodonium tetrafluoroborate (IPy(2)BF(4)) as an oxidizing agent towards different types alcohols is reported. observed reactivity involves reaction pathways, a function both the structures starting materials and experimental conditions. Interestingly, title iodine-containing compound capable tuneable with simple cycloalkanols, providing straight selective access either to omega-iodocarbonyl compounds or ketones, previously unreported chemoselective range oxidation...

Abstract Neutral and cationic series of new trimeric β‐hydroxy amino or ammonium surfactants were synthesized via a two‐step process involving the Williamson etherification regioselective oxirane ring opening with primary tertiary amines, which afforded good to excellent yields. The compounds obtained in high purity by simple purification procedure on column chromatography. critical micelle concentration (CMC), effectiveness surface tension reduction ( γ CMC ), excess (Γ), area per molecule...

A novel series of neutral and cationic dimeric surfactants were prepared involving ketalization reaction, Williamson etherification, regioselective oxirane ring opening with primary tertiary alkyl amines. The critical micelle concentration (CMC), effectiveness surface tension reduction (gamma(CMC)), excess (Gamma), area per molecule at the interface (A) determined values indicate that is characterized by good surface-active self-aggregation properties. For first time, we reported...

This work studies the effect of mesostructured silica–zirconia–tungstophosphoric acid (SiO2-ZrO2-TPA) composites used as catalysts in synthesis nifedipine by Hantzsch methodology. The selectivity for is determined, along with that secondary products may form depending on reaction conditions. materials were synthesized via sol–gel method and characterized N2 adsorption–desorption isotherms, infrared spectroscopy (FT-IR), 31P solid-state nuclear magnetic resonance (NMR-MAS), X-ray diffraction...

Quaternary ammonium compounds are widely used as antiseptic and disinfectant. It is been a concern that their widespread use will lead to an increase of environmental problems, therefore the development biodegradable surfactants necessary. The present research aimed at design novel amphiphilic molecules with similar properties those already known but more biodegradable. Based on benzalkonium chloride (BAC), carbonate cleavable (CBAC) were synthesized. breakable sites make CBAC degradable...

Abstract A series of new N‐acetylated non‐ionic and cationic gemini surfactants ( 3a–f ) having dimeric structures derived from primary tertiary amines with variably long tails (C 8 –C 12 18 were synthesized. In addition, monomeric analogues 6a 6b prepared their antifungal potency surface properties also determined. Critical micelle concentration (CMC), effectiveness tension reduction (γ CMC ), excess (Γ), area per molecule at the interface determined resulting values indicate that is...

A series of N-acetylated cationic gemini surfactants (3a-e) having dimeric structures derived from tertiary amines were synthesized. Their antifungal potency and surface properties determined. It also studied the acute toxicity molecule with best performance water solubility (3e) through Chlorella vulgaris Daphnia magna bioassays. The results compared to those obtained for a commercially available reference compound 2-(thiocyanomethylthio) benzothiazole (TCMTB). Parameters such as tension...

New dimeric or gemini surfactants bearing double-chain with two four sulfonate groups, and quadruple-chain were prepared from pentaerythritol in good overall yields. All these showed excellent surface-active properties.

The selective preparation of monoketals 3a-f from pentaerythritol 1 and cyclic, acyclic, aromatic, aliphatic ketones 2a-f was achieved by a facile method. extreme polarity low solubility in almost all organic solvents were the main difficulties to be overcome for good yields high selectivity. A benzene-dimethylformamide (40:60) mixture proved excellent ketalization. one-step procedure developed allowed selectivity (higher than 90%).

Abstract A novel series of cleavable alkyltrimethylammonium surfactants with different hydrocarbon chain lengths (C8–16) were synthesized. carbonate break site inserted between the polar head and makes these compounds hydrolyzable. The reagents used are renewable, (bio)degradable, or reusable. hydrolysis will lead to generation fatty alcohols choline, which is an essential biological nutrient. surface activities in aqueous solution synthesized carbonates fulfill requirement being good...

Abstract A novel series of cationic dimeric surfactants was prepared involving the ketalization reaction, Williamson etherification, and regioselective oxirane ring opening with tertiary alkyl amines. The synthesized compounds were obtained in high purity by a simple purification procedure using column chromatography. critical micelle concentration (CMC), effectiveness surface tension reduction (γ CMC ), excess (Γ), area per molecule at interface ( ) determined values indicate that is...

A relative bioavailability study (RBA) of two phenytoin (PHT) formulations was conducted in rabbits, order to compare the results obtained from different matrices (plasma and blood dried spot (DBS) sampling) experimental designs (classic block). The method developed by liquid chromatography tandem-mass spectrometry (LC-MS/MS) plasma samples. sample preparation techniques, protein precipitation DBS, were validated according international requirements. analytical with ranges 0.20–50.80...

A series of six pyrazoles was synthesized by Michael-type addition reaction. The molecules 5-amino-1-aryl-1H-pyrazole-4-carbonitrile (3a-f) were from (ethoxymethylene)malo-nonitrile (1) and fluorinated non-fluorinated aryl hydrazines (2a-f) using ethanol as solvents at reflux. An excellent regio-selectivity found when pyrazole derivatives formed an exclusive product. No other regioisomer or uncyclised hydrazide observed. Their structures confirmed spectroscopy data (1H, 13C, 19F, COSY...

In recent years, the processing and consumption of functional foods worldwide have greatly increased. These benefit body functions which improve consumers’ health also reduce risk factors that cause onset disease. Furthermore, prebiotic substances favor multiplication beneficial intestinal bacteria rather than harmful ones. The purpose this study was to conduct sensory evaluation two cheeses containing inulin oligofructose as a distinctive ingredient, including testing cheese made with...