Marcelo C. Murguía

ORCID: 0000-0003-2222-8690
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About
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Research Areas
  • Surfactants and Colloidal Systems
  • Environmental Chemistry and Analysis
  • Synthesis and Biological Evaluation
  • Synthesis and Reactions of Organic Compounds
  • Antimicrobial agents and applications
  • Multicomponent Synthesis of Heterocycles
  • Synthesis and biological activity
  • Fluorine in Organic Chemistry
  • Chemical Synthesis and Reactions
  • Synthesis of heterocyclic compounds
  • Oxidative Organic Chemistry Reactions
  • Analytical Chemistry and Chromatography
  • Crystallization and Solubility Studies
  • Organic and Inorganic Chemical Reactions
  • Advanced Polymer Synthesis and Characterization
  • Synthetic Organic Chemistry Methods
  • Click Chemistry and Applications
  • Inorganic and Organometallic Chemistry
  • Synthesis and Reactivity of Sulfur-Containing Compounds
  • Porphyrin and Phthalocyanine Chemistry
  • Microbial bioremediation and biosurfactants
  • Biosimilars and Bioanalytical Methods
  • Clinical Laboratory Practices and Quality Control
  • Nanocomposite Films for Food Packaging
  • Synthesis and Reactivity of Heterocycles

National University of the Littoral
2011-2025

Consejo Nacional de Investigaciones Científicas y Técnicas
2001-2024

Instituto de Desarrollo Tecnológico para la Industria Química
2001-2021

Weatherford College
2008-2012

Universitat de València
2008-2010

Centro de Investigacion Principe Felipe
2008

Universidad de Oviedo
2004

Universidad Nacional de Córdoba
1997

The preparation of N-methylpyrazoles is usually accomplished through reaction a suitable 1,3-diketone with methylhydrazine in ethanol as the solvent. This strategy, however, leads to formation regioisomeric mixtures N-methylpyrazoles, which sometimes are difficult separate. We have determined that use fluorinated alcohols such 2,2,2-trifluoroethanol (TFE) and 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) solvents dramatically increases regioselectivity pyrazole formation, we used this...

10.1021/jo800251g article EN The Journal of Organic Chemistry 2008-04-10

A small library of compounds with an oxa(thia)zole scaffold and structural diversity in both positions 2 5 has been synthesized. Double acylation a protected glycine affords intermediate α-amido-β-ketoesters, which turn can be dehydrated to afford 1,3-oxazoles or reacted Lawesson's reagent furnish 1,3-thiazoles. This procedure was designed its adaptation fluorous techniques mind. Thus, when tag the ester moiety is used as starting material, synthesis easily completed without column...

10.1021/jo9016265 article EN The Journal of Organic Chemistry 2009-11-06

The use of bis(pyridine)iodonium tetrafluoroborate (IPy(2)BF(4)) as an oxidizing agent towards different types alcohols is reported. observed reactivity involves reaction pathways, a function both the structures starting materials and experimental conditions. Interestingly, title iodine-containing compound capable tuneable with simple cycloalkanols, providing straight selective access either to omega-iodocarbonyl compounds or ketones, previously unreported chemoselective range oxidation...

10.1002/chem.200400136 article EN Chemistry - A European Journal 2004-07-09

Abstract Neutral and cationic series of new trimeric β‐hydroxy amino or ammonium surfactants were synthesized via a two‐step process involving the Williamson etherification regioselective oxirane ring opening with primary tertiary amines, which afforded good to excellent yields. The compounds obtained in high purity by simple purification procedure on column chromatography. critical micelle concentration (CMC), effectiveness surface tension reduction ( γ CMC ), excess (Γ), area per molecule...

10.1007/s11743-007-1052-4 article EN Journal of Surfactants and Detergents 2008-01-03

A novel series of neutral and cationic dimeric surfactants were prepared involving ketalization reaction, Williamson etherification, regioselective oxirane ring opening with primary tertiary alkyl amines. The critical micelle concentration (CMC), effectiveness surface tension reduction (gamma(CMC)), excess (Gamma), area per molecule at the interface (A) determined values indicate that is characterized by good surface-active self-aggregation properties. For first time, we reported...

10.5650/jos.57.301 article EN Journal of Oleo Science 2008-01-01

This work studies the effect of mesostructured silica–zirconia–tungstophosphoric acid (SiO2-ZrO2-TPA) composites used as catalysts in synthesis nifedipine by Hantzsch methodology. The selectivity for is determined, along with that secondary products may form depending on reaction conditions. materials were synthesized via sol–gel method and characterized N2 adsorption–desorption isotherms, infrared spectroscopy (FT-IR), 31P solid-state nuclear magnetic resonance (NMR-MAS), X-ray diffraction...

10.3390/catal15060537 article EN Catalysts 2025-05-28

Quaternary ammonium compounds are widely used as antiseptic and disinfectant. It is been a concern that their widespread use will lead to an increase of environmental problems, therefore the development biodegradable surfactants necessary. The present research aimed at design novel amphiphilic molecules with similar properties those already known but more biodegradable. Based on benzalkonium chloride (BAC), carbonate cleavable (CBAC) were synthesized. breakable sites make CBAC degradable...

10.5650/jos.ess20216 article EN cc-by-sa Journal of Oleo Science 2021-01-01

Abstract A series of new N‐acetylated non‐ionic and cationic gemini surfactants ( 3a–f ) having dimeric structures derived from primary tertiary amines with variably long tails (C 8 –C 12 18 were synthesized. In addition, monomeric analogues 6a 6b prepared their antifungal potency surface properties also determined. Critical micelle concentration (CMC), effectiveness tension reduction (γ CMC ), excess (Γ), area per molecule at the interface determined resulting values indicate that is...

10.1007/s11743-008-1076-4 article EN Journal of Surfactants and Detergents 2008-07-10

A series of N-acetylated cationic gemini surfactants (3a-e) having dimeric structures derived from tertiary amines were synthesized. Their antifungal potency and surface properties determined. It also studied the acute toxicity molecule with best performance water solubility (3e) through Chlorella vulgaris Daphnia magna bioassays. The results compared to those obtained for a commercially available reference compound 2-(thiocyanomethylthio) benzothiazole (TCMTB). Parameters such as tension...

10.4236/aces.2015.52023 article EN Advances in Chemical Engineering and Science 2015-01-01

New dimeric or gemini surfactants bearing double-chain with two four sulfonate groups, and quadruple-chain were prepared from pentaerythritol in good overall yields. All these showed excellent surface-active properties.

10.1055/s-2001-16060 article EN Synlett 2001-01-01

The selective preparation of monoketals 3a-f from pentaerythritol 1 and cyclic, acyclic, aromatic, aliphatic ketones 2a-f was achieved by a facile method. extreme polarity low solubility in almost all organic solvents were the main difficulties to be overcome for good yields high selectivity. A benzene-dimethylformamide (40:60) mixture proved excellent ketalization. one-step procedure developed allowed selectivity (higher than 90%).

10.1055/s-2001-14569 article EN Synthesis 2002-07-26

Abstract A novel series of cleavable alkyltrimethylammonium surfactants with different hydrocarbon chain lengths (C8–16) were synthesized. carbonate break site inserted between the polar head and makes these compounds hydrolyzable. The reagents used are renewable, (bio)degradable, or reusable. hydrolysis will lead to generation fatty alcohols choline, which is an essential biological nutrient. surface activities in aqueous solution synthesized carbonates fulfill requirement being good...

10.1002/jsde.12507 article EN Journal of Surfactants and Detergents 2021-03-24

Abstract A novel series of cationic dimeric surfactants was prepared involving the ketalization reaction, Williamson etherification, and regioselective oxirane ring opening with tertiary alkyl amines. The synthesized compounds were obtained in high purity by a simple purification procedure using column chromatography. critical micelle concentration (CMC), effectiveness surface tension reduction (γ CMC ), excess (Γ), area per molecule at interface ( ) determined values indicate that is...

10.1007/s11743-012-1337-0 article EN Journal of Surfactants and Detergents 2012-03-07

A relative bioavailability study (RBA) of two phenytoin (PHT) formulations was conducted in rabbits, order to compare the results obtained from different matrices (plasma and blood dried spot (DBS) sampling) experimental designs (classic block). The method developed by liquid chromatography tandem-mass spectrometry (LC-MS/MS) plasma samples. sample preparation techniques, protein precipitation DBS, were validated according international requirements. analytical with ranges 0.20–50.80...

10.1177/0023677217734235 article EN Laboratory Animals 2017-10-23

A series of six pyrazoles was synthesized by Michael-type addition reaction. The molecules 5-amino-1-aryl-1H-pyrazole-4-carbonitrile (3a-f) were from (ethoxymethylene)malo-nonitrile (1) and fluorinated non-fluorinated aryl hydrazines (2a-f) using ethanol as solvents at reflux. An excellent regio-selectivity found when pyrazole derivatives formed an exclusive product. No other regioisomer or uncyclised hydrazide observed. Their structures confirmed spectroscopy data (1H, 13C, 19F, COSY...

10.4236/aces.2015.53025 article EN Advances in Chemical Engineering and Science 2015-01-01

In recent years, the processing and consumption of functional foods worldwide have greatly increased. These benefit body functions which improve consumers’ health also reduce risk factors that cause onset disease. Furthermore, prebiotic substances favor multiplication beneficial intestinal bacteria rather than harmful ones. The purpose this study was to conduct sensory evaluation two cheeses containing inulin oligofructose as a distinctive ingredient, including testing cheese made with...

10.4236/fns.2015.616153 article EN Food and Nutrition Sciences 2015-01-01
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