A5042255401- Antibiotic Resistance in Bacteria
- Enterobacteriaceae and Cronobacter Research
- Pharmaceutical and Antibiotic Environmental Impacts
- Bacterial biofilms and quorum sensing
- Bacterial Identification and Susceptibility Testing
- Infections and bacterial resistance
- Salmonella and Campylobacter epidemiology
- Antibiotics Pharmacokinetics and Efficacy
- Vibrio bacteria research studies
- Escherichia coli research studies
- Antimicrobial Resistance in Staphylococcus
- Bacteriophages and microbial interactions
- Bacterial Genetics and Biotechnology
- Plant Pathogenic Bacteria Studies
- Pneumonia and Respiratory Infections
- Tuberculosis Research and Epidemiology
- Antibiotic Use and Resistance
- Mycobacterium research and diagnosis
- Plant Pathogens and Fungal Diseases
- Streptococcal Infections and Treatments
- Neonatal and Maternal Infections
- Urinary Tract Infections Management
- Enzyme Production and Characterization
- Diphtheria, Corynebacterium, and Tetanus
- Plant Disease Management Techniques
University of Buenos Aires
2016-2025
Consejo Nacional de Investigaciones Científicas y Técnicas
2017-2025
Centro Científico Tecnológico - San Juan
2018-2021
Universidad Adventista del Plata
2021
National University of the Littoral
2007-2016
Consejo Superior de Investigaciones Científicas
2001
Early after the introduction of first (narrow spectrum) penicillins into clinical use, penicillinase-producing staphylococci replaced (worldwide) previously susceptible microorganisms. Similarly, extensive use broad-spectrum, orally administered β- lactams (like ampicillin, amoxicillin or cefalexin) provided a favorable scenario for selection gram-negative microorganisms producing broad spectrum β-lactamases almost 45 years ago. These could be controlled by so called "extended...
The use of antimicrobial growth promoters (AGPs) in sub-therapeutic doses for long periods promotes the selection resistant microorganisms and subsequent risk spreading this resistance to human population environment. Global concern about development transference genes from animal has been rising. goal our research was evaluate susceptibility pattern different classes antimicrobials colistin-resistant Escherichia coli poultry production systems that AGPs, characterize determinants associated...
ABSTRACT The genetic organization of the region coding for CTX-M-2 in Salmonella enterica serovar Infantis was determined by PCR mapping. This gene seems to have been mobilized from Kluyvera ascorbata chromosome a complex sulI -type integron, similar In6 and In7.
ABSTRACT A multicenter survey, carried out in 2010 Argentina, showed an increased prevalence of extended-spectrum β-lactamase (ESBL)-producing enterobacteria, with some changes the molecular epidemiology circulating ESBLs. While enzymes CTX-M-2 group remain endemic, emergence CTX-M-15 and CTX-M-8 CTX-M-9 groups was observed. The CTX-M-15-positive isolates represented 40% CTX-M producers included representatives Escherichia coli ST131 Klebsiella pneumoniae ST11.
Objective: to describe at genomic level nine carbapenemase-producing Klebsiella pneumoniae ST307 (Kp-ST307) clinical isolates recovered in Buenos Aires during 2017-2021, investigating their resistome, virulome and phylogeny. Methods: Antimicrobial susceptibility was determined according CLSI. Genomic DNA sequenced by Illumina MiSeq analyzed using SPAdes, PROKKA Kleborate. Phylogeny of 355 randomly selected Kp-ST307 genomes those from local inferred a maximum-likelihood approach. The tree...
Abstract Neutral and cationic series of new trimeric β‐hydroxy amino or ammonium surfactants were synthesized via a two‐step process involving the Williamson etherification regioselective oxirane ring opening with primary tertiary amines, which afforded good to excellent yields. The compounds obtained in high purity by simple purification procedure on column chromatography. critical micelle concentration (CMC), effectiveness surface tension reduction ( γ CMC ), excess (Γ), area per molecule...
A novel series of neutral and cationic dimeric surfactants were prepared involving ketalization reaction, Williamson etherification, regioselective oxirane ring opening with primary tertiary alkyl amines. The critical micelle concentration (CMC), effectiveness surface tension reduction (gamma(CMC)), excess (Gamma), area per molecule at the interface (A) determined values indicate that is characterized by good surface-active self-aggregation properties. For first time, we reported...
Reports of Gram-negative bacteria harboring multiple carbapenemase genes have increased in South America, leading to an urgent need for appropriate microbiological diagnosis. We evaluated phenotypic methods detecting Klebsiella pneumoniae 2 (KPC-2) and New Delhi metallo-β-lactamase-1 (NDM-1) coexpression members the K. complex (i.e., pneumoniae, quasipneumoniae, variicola) isolated from human animal hosts, based on inhibition ceftazidime-avibactam (CZA) aztreonam (ATM) by dipicolinic acid...
Abstract In physics education, the perception of a low level significant learning has been evident regarding one-dimensional motion in Ecuador; this may be due to lack modernization teaching methods, which have remained rooted traditional education. From perspective, present research work is focused on analysing implication using an active strategy, such as flipped classroom, and its impact about motion. For purpose, control experimental group was selected pre-test post-test were applied....
During the COVID-19 pandemic, emergence of multidrug-resistant (MDR) pathogens, driven by heightened antibiotic usage and device-associated infections, has posed significant challenges to healthcare. This study reports an outbreak Proteus mirabilis producing NDM-5 CTX-M-15 β-lactamases in a hospital Buenos Aires, Argentina, from October 2020 April 2021. To our knowledge, this represents first documented NDM-5-producing P. country. Eighty-two isolates were recovered 40 patients, 41.5% blood...
Background: During the COVID-19 pandemic, emergence of multidrug-resistant (MDR) pathogens, driven by heightened antibiotic usage and device-associated infections, has posed significant challenges to healthcare. This study reports an outbreak Proteus mirabilis producing NDM-5 CTX-M-15 β-lactamases in a hospital Buenos Aires, Argentina, from October 2020 April 2021. To our knowledge, this represents first documented NDM-5-producing P. country. Methods: A total 82 isolates were recovered 40...
Objectives: We analysed the architecture and probable origin of a class 1 integron from cefotaxime-resistant Morganella morganii isolates.
Resistance to β-lactam/β-lactamase inhibitors in enterobacteria is a growing problem that has not been intensively studied Argentina. In the present work, 54/843 collected teaching hospital of Buenos Aires city were ampicillin-sulbactam-resistant isolates remaining susceptible second- and third-generation cephalosporins. The enzymatic mechanisms isolates, which also amoxicillin-clavulanic acid (AMC)-resistant (18/54) herein analyzed. Sequencing revealed two different variants blaTEM-1, being...
High quinolone resistance rates were observed among oxyiminocephalosporin-resistant enterobacteria. In the present study, we searched for prevalence of plasmid-mediated (PMQR) genes within 55 enterobacteria collected in a previous survey. The main PMQR determinants aac(6')-Ib-cr and qnrB, which had 42.4% 33.3%, respectively. aac(6')-Ib-crgene was more frequently found CTX-M-15-producing isolates, while qnrB homogeneously distributed all CTX-M producers.
Nosocomial infections caused by multidrug-resistant (MDR) Klebsiella pneumoniae are a major health problem worldwide. The aim of this study was to describe NDM-1-producing K. strains causing bacteremia in tertiary referral hospital Mexico. MDR isolates were screened polymerase chain reaction for the presence resistance genes. In resistant isolates, plasmids identified and conjugation assays performed. Clonal diversity sequence types determined pulsed-field gel electrophoresis multilocus...
The aim of this study was to investigate the presence class 1 integrons in a collection Shiga toxin-producing Escherichia coli (STEC) from different origins and characterize pheno- genotypically antimicrobial resistance associated them. A 649 isolates were screened for integrase gene (intI1) by Polymerase chain reaction variable region amplified sequenced. Positive strains evaluated genes with microarray susceptibility disk diffusion method. Seven out STEC some serogroups, O26, O103 O130...