A5089941882- Coccidia and coccidiosis research
- HIV/AIDS drug development and treatment
- Carbohydrate Chemistry and Synthesis
- Synthesis and biological activity
- Biochemical and Molecular Research
- Drug Solubulity and Delivery Systems
- Nematode management and characterization studies
- Helminth infection and control
- vaccines and immunoinformatics approaches
- Crystallization and Solubility Studies
- Computational Drug Discovery Methods
Universidad de la República de Uruguay
2020-2023
Introduction: The identification of chemical compounds that interfere with SARS-CoV-2 replication continues to be a priority in several academic and pharmaceutical laboratories. Computational tools approaches have the power integrate, process analyze multiple data short time. However, these initiatives may yield unrealistic results if applied models are not inferred from reliable resulting predictions confirmed by experimental evidence. Methods: We undertook drug discovery campaign against...
Background: Infections caused by helminth parasites are the main cause of economic losses in livestock industry worldwide. The rapid resistance acquired different against commercially available drugs motivates search, design and development new compounds capable overcoming this situation. Previously, our group reported novel hybrid valerolactam-fenbendazole (VAL-FBZ) compound with vitro anthelmintic activity good ex vivo parasite permeation. Objective: Optimization VAL-FBZ synthesis scale-up...
The preparation of a new non-natural gabosine is reported, in which the chirality transferred from toluene’s biotransformed metabolite (1R,2S)-3-methylcyclohexa-3.5-diene-1,2-diol. Further chemical transformations to introduce additional functionality and molecule were also accomplished.