A5000096741- Malaria Research and Control
- Quantum Dots Synthesis And Properties
- Mosquito-borne diseases and control
- vaccines and immunoinformatics approaches
- Computational Drug Discovery Methods
- Sulfur-Based Synthesis Techniques
- Chemical Synthesis and Reactions
- Organoselenium and organotellurium chemistry
- Chalcogenide Semiconductor Thin Films
- Hepatitis C virus research
- Advanced biosensing and bioanalysis techniques
- Traditional and Medicinal Uses of Annonaceae
- Nanocluster Synthesis and Applications
- Cyberloafing and Workplace Behavior
- Carbon and Quantum Dots Applications
Columbia University Irving Medical Center
2025
Universidade de São Paulo
2022-2024
Universidade Federal de São Carlos
2024
Universidade Federal de Pernambuco
2016-2023
Identification of novel drug targets is a key component modern discovery. While antimalarial are often identified through the mechanism action studies on phenotypically derived inhibitors, this method tends to be time- and resource-consuming. The discoverable target space also constrained by existing compound libraries phenotypic assay conditions. Leveraging recent advances in protein structure prediction, we systematically assessed Plasmodium falciparum genome 867 candidate with evidence...
Abstract In this study, we present the optimization of optical properties Mn 2+ doped ZnSe QDs (also referred to as d‐dots) coated with thioglycolic acid in aqueous medium. The nanoparticles were characterized by ionic coupled plasma, electron paramagnetic resonance, transmission microscopy and X‐ray diffractometry. By applying a controlled dose UV irradiation, obtained efficient orange emitting d‐dots ( 4 T 1 → 6 A transition centered at 580 nm). results point out doping fraction smaller...
Abstract The development of new catalytic methods based on lower-cost metals under environmentally friendly conditions is still a challenge. Herein, we report an efficient strategy for the synthesis vinyl sulfones from O-propargyl alkynes and sodium salts sulfinic acids using silver nitrate, inexpensive readily available catalyst, air atmosphere aqueous conditions. products were obtained in good to moderate yields, mechanism reaction was also investigated.
A novel strategy for the synthesis of sulfides and selenides from phosphonium salts thio- or selenesulfonates, commercially available compounds, is described. When phosphoranes were used in reaction, different products obtained. The methodology does not require use metals, reactive species, anhydrous conditions to be performed.
Malaria control and elimination efforts would benefit from the identification validation of new malaria chemotherapeutics. Recently, a transgenic Plasmodium berghei line was used to perform series high-throughput in vitro screens for antimalarials acting against parasite sexual stages. The identified pyrimidine azepine chemotypes with potent activity. Here, we validate activity PyAz90, most chemotype identified, P. falciparum vivax asexual PyAz90 blocked transmission mosquito vector at...
<title>Abstract</title> The identification of novel drug targets for the purpose designing small molecule inhibitors is key component to modern discovery. In malaria parasites, discoveries antimalarial have primarily occurred retroactively by investigating mode action compounds found through phenotypic screens. Although this method has yielded many promising candidates, it time- and resource-consuming misses not captured existing compound libraries assay conditions. Leveraging recent...
Malaria is a parasitic disease caused by protozoan parasites from the genus Plasmodium. Plasmodium falciparum most prevalent species worldwide and causative agent of severe malaria. The spread resistance to currently available antimalarial therapy major concern. Therefore, it imperative discover develop new drugs, which not only treat but also control emerging resistance. Brussonol an icetexane derivative member family diterpenoids that have been isolated several terrestrial plants. Here,...