A5087444551- Gut microbiota and health
- Malaria Research and Control
- Epigenetics and DNA Methylation
- Clostridium difficile and Clostridium perfringens research
- Mycobacterium research and diagnosis
- Ginseng Biological Effects and Applications
- vaccines and immunoinformatics approaches
- Computational Drug Discovery Methods
- Food composition and properties
- Peptidase Inhibition and Analysis
- Microbial Metabolites in Food Biotechnology
- Aquaculture disease management and microbiota
- Outsourcing and Supply Chain Management
- Food Quality and Safety Studies
- Trypanosoma species research and implications
- Employment and Welfare Studies
- RNA modifications and cancer
- Invertebrate Immune Response Mechanisms
- Hepatitis C virus research
- RNA and protein synthesis mechanisms
- Seed and Plant Biochemistry
- Multiple Myeloma Research and Treatments
- Mosquito-borne diseases and control
- Phytoestrogen effects and research
- Biochemical and Molecular Research
University of California, San Diego
2022-2025
University of California, Los Angeles
2021-2023
National Changhua University of Education
2015
Although the ecological dynamics of infant gut microbiome have been intensely studied, relatively little is known about evolutionary in microbiome. Here we analyze longitudinal fecal metagenomic data from more than 700 infants and their mothers over first year life find that microbiomes are distinct those adults. We evidence for a 10-fold increase rate evolution strain turnover compared with healthy adults, mother-infant transition at delivery being particularly dynamic period which gene...
Identification of novel drug targets is a key component modern discovery. While antimalarial are often identified through the mechanism action studies on phenotypically derived inhibitors, this method tends to be time- and resource-consuming. The discoverable target space also constrained by existing compound libraries phenotypic assay conditions. Leveraging recent advances in protein structure prediction, we systematically assessed Plasmodium falciparum genome 867 candidate with evidence...
The human gut microbiome contains a diversity of microbial species that varies in composition over time and across individuals. These (and strains within species) can migrate hosts evolve by mutation recombination hosts. How the ecological process community assembly interacts with intra-species evolutionary change is longstanding question. Two contrasting hypotheses have been proposed based on observations theory: Diversity Begets (DBD), which taxa tend to become more diverse already...
Genetic variation in the human gut microbiome is responsible for conferring a number of crucial phenotypes like ability to digest food and metabolize drugs. Yet, our understanding how this arises maintained remains relatively poor. Thus, largely untapped resource, as large coexisting species presents unique opportunity compare contrast evolutionary processes across identify universal trends deviations. Here we outline features that, while not isolation, an assemblage make it system with...
Herein we report the finding and structure determination of a natural product based on methyldeoxaphomin scaffold family from fungus Trichocladium asperum that shows promising antiplasmodial activity selectivity against host cells. In vitro evolution whole genome analysis in Plasmodium falciparum with most potent member, NPDG-F (EC 50 550 nM Dd2; 290 3D7), parasite resistance to methyldeoxaphomins is strongly associated mutations PfActin1 (PF3D7_1246200), critically essential ATPase needed...
Surveillance of drug resistance and the discovery novel targets—key objectives in fight against malaria—rely on identifying resistance-conferring mutations Plasmodium parasites. Current approaches, while successful, require laborious experimentation or large sample sizes. To elucidate shared determinants antimalarial that can empower silico inference, we examined genomes 724 falciparum clones, each selected vitro for to one 118 compounds. We identified 1448 variants 128 recurrently mutated...
Malaria is a devastating disease caused by
Abstract The human gut microbiome contains a diversity of microbial species that varies in composition over time and across individuals. These (and strains within species) can migrate hosts evolve by mutation recombination hosts. How the ecological process community assembly interacts with intra-species evolutionary change is longstanding question. Two contrasting hypotheses have been proposed based on observations theory: Diversity Begets (DBD), which taxa tend to become more diverse...
<title>Abstract</title> The precise mode of action ganaplacide (KAF156), a phase III antimalarial candidate, remains elusive. Here we employ omics-based methods with the closely related chemical analog, GNF179, to search for potential <italic>Plasmodium</italic> targets. Ranking targets derived from genetics and proteomic affinity chromatography methodologies identifies <italic>SEY1</italic>, or Synthetic Enhancement YOP1, which is predicted encode an essential dynamin-like GTPase implicated...
<title>Abstract</title> The identification of novel drug targets for the purpose designing small molecule inhibitors is key component to modern discovery. In malaria parasites, discoveries antimalarial have primarily occurred retroactively by investigating mode action compounds found through phenotypic screens. Although this method has yielded many promising candidates, it time- and resource-consuming misses not captured existing compound libraries assay conditions. Leveraging recent...
Abstract The genetic variation in the human gut microbiome is responsible for conferring a number of crucial phenotypes like ability to digest food and metabolize drugs. Yet, our understanding how this arises maintained remains relatively poor. Thus, largely untapped resource, as large co-existing species presents unique opportunity compare contrast evolutionary processes across identify universal trends deviations. Here we outline features that, while not isolation, an assemblage make it...