A5083999048- Malaria Research and Control
- Mosquito-borne diseases and control
- Hemoglobinopathies and Related Disorders
- Drug Transport and Resistance Mechanisms
- Erythrocyte Function and Pathophysiology
- HIV Research and Treatment
- Travel-related health issues
- Tuberculosis Research and Epidemiology
- Advanced Drug Delivery Systems
- Nanoparticle-Based Drug Delivery
- Neonatal Health and Biochemistry
- Metabolism and Genetic Disorders
- Quinazolinone synthesis and applications
Universidade Nova de Lisboa
2024
Severe malaria is a major public health concern in Angola, particularly among adults, with limited data on clinical outcomes and manifestations. The study therefore assessed the manifestations outcome of severe Plasmodium falciparum adult patients admitted to Hospital Central Dr. António Agostinho Neto Lubango, Angola. retrospectively reviewed individual records over 14 years old, for during first trimester 2021 2022. World Health Organization (WHO) criteria were used define severity. A...
Malaria remains a major world public health problem, contributing to poverty and inequality. It is urgent find new efficacious tools with few adverse effects. has selected red blood cell (RBC) alterations linked resistance against infection, understanding the protective mechanisms involved may be useful for developing host-directed control Plasmodium infection. Pyruvate kinase deficiency been associated malaria. kinase-deficient RBCs display an increased concentration of...
Mechanisms of malaria parasite interaction with its host red blood cell may provide potential targets for new antimalarial approaches. Pyruvate kinase deficiency has been associated resistance to in both experimental models and population studies. Two the major pyruvate deficient-cell disorders are decrease ATP increase 2,3-biphosphoglycerate (2,3-BPG) concentration. High levels this metabolite, only present mammalian cell, an inhibitory effect on glycolysis we hypothesized that accumulation...
Severe malaria poses a significant public health concern in Angola, particularly among adults. This study assessed the clinical manifestations and outcomes of severe