Five community-based cross-sectional surveys of malaria morbidity and associated risk factors in remote riverine populations northwestern Brazil showed average parasite rates 4.2% (thick-smear microscopy) 14.4% (polymerase chain reaction [PCR]) the overall population, with a spleen rate 13.9% among children 2–9 years age. Plasmodium vivax was 2.8 times more prevalent than P. falciparum , rare instances malariae mixed-species infections confirmed by PCR; 9.6% asymptomatic subjects had...

The relation of Zika virus (ZIKV) with microcephaly is well established. However, knowledge lacking on later developmental outcomes in children evidence maternal ZIKV infection during pregnancy born without microcephaly. objective this analysis to investigate the impact prenatal exposure neuropsychomotor development We evaluated 274 including 235 exposed and 39 controls using Bayley-III Scales Infant Toddler Development (BSIDIII) neurological examination. observed a difference cognition...

Malaria remains a major world public health problem, contributing to poverty and inequality. It is urgent find new efficacious tools with few adverse effects. has selected red blood cell (RBC) alterations linked resistance against infection, understanding the protective mechanisms involved may be useful for developing host-directed control Plasmodium infection. Pyruvate kinase deficiency been associated malaria. kinase-deficient RBCs display an increased concentration of...

A descriptive, entomological and seroepidemiological study on Chagas disease was conducted in a place of recent occupation the outskirts Cochabamba, Bolivia: Avaroa/Primer de Mayo (population:3,000), where socio-economic level is low no control measures have been made available.The immunofluorescent antibody test (IFAT) used for IgG IgM anti-Trypanosoma cruzi antibodies filter paper bloodspot eluates from 128 subjects (73 females, 55 males) selected by systematic sampling. Concerning each...

A critical role has been proposed for the switch from non-cytophilic IgG2 to cytophilic antibodies of IgG1 and IgG3 subclasses observed in humoral immune responses Plasmodium falciparum some Africans. These Africans have acquired clinically immunity naturally, after several years exposure holo-endemic malaria. In present study, possibility that life-long low levels malarial endemicity may be associated with changes IgG-subclass composition P. was investigated a native Amazonian community....

Registraram-se, nos últimos vinte anos, casos autóctones de malária por Plasmodium vivax no Município Peruíbe (24,19ºS e 47,00ºW), Litoral Sul do Estado São Paulo, com presença portadores assintomáticos ou oligossintomáticos associada não a parasitemias subpatentes. O problema na área é também conhecido como "bromélia-malária"; os vetores pertencem ao subgênero Kerteszia: Anopheles (K.) cruzii A. bellator. A partir segundo semestre 1984 foram realizados, semestralmente, inquéritos...

OBJETIVO: Analisar dados de reações sorológicas realizadas em dois períodos, entre fins da década 1960 e o ano 1983, quando a sorologia passou complementar informação sobre triatomíneos vetores do Estado São Paulo e, 1984 até 1999, caracterizando panorama atual endemia nessa região. MÉTODOS: Foram análises soroepidemiológicas reações, obtidas inquéritos escolares (fins 1973 1983), populacionais Cananéia, Iguape Peruíbe (entre 1980 1982) moradores unidades domiciliares. Os resultados análise...

Mechanisms of malaria parasite interaction with its host red blood cell may provide potential targets for new antimalarial approaches. Pyruvate kinase deficiency has been associated resistance to in both experimental models and population studies. Two the major pyruvate deficient-cell disorders are decrease ATP increase 2,3-biphosphoglycerate (2,3-BPG) concentration. High levels this metabolite, only present mammalian cell, an inhibitory effect on glycolysis we hypothesized that accumulation...

Blood sampling on filter paper is a current practice in malaria seroepidemiological studies by indirect fluorescent antibody test (IFAT). There is, however, scant comparative information about the use of bloodspot eluates for detection malarial IgG antibodies simultaneously IFAT and enzyme immunoassay (ELISA). Here we report data obtained both serological methods done 219 eluate samples collected rural community Brazilian Amazon Basin (Alto Paraíso, Ariquemes municipality) where endemic....

O objetivo, aqui, é relatar a persistência, em localidades do Estado de São Paulo, alta infestação triatomíneos vetores da doença Chagas. Analisaram-se bancos dados com informações trabalhadas para todo o no período 1990 1999. Em 43 localidades, distribuídas 21 municípios concentrados na região Araçatuba, observaram-se, sempre, altos índices infestação. A espécie predominante foi Triatoma sordida presença marcante peridomicílio. Os exemplares capturados, sua maioria adultos fêmeas e ninfas...

Como parte de avaliação medidas controle vetores, levadas a efeito no Estado São Paulo, na década 60, inquéritos sorológicos entre crianças escolares nascidas após sua aplicação foram realizados nos períodos abrangidos os anos 1968 e 1970, em todos municípios do estado, à exceção dos da Grande Paulo e, anualmente, 1973 1983, amostra selecionada partir daqueles com as maiores soroprevalências para infecção chagásica. No primeiro caso, metodologia sorológica previu exames base reação fixação...

This study aims to analyze the effect of domiciliary infestation by triatomine bugs on degree which inhabitants are aware potential vector transmission Chagas disease. Such recently constructed dwellings comprise housing groups classified as settlements and re-settlements, selected respectively in municipalities Euclides da Cunha Paulista Paulicéia, São Paulo State, Brazil. Both under jurisdiction Presidente Prudente Health Administrative Region. Of 319 residents, some 100 (76.0% whom were...

We estimated the proportion of seropositivity for infection with Trypanosoma cruzi (Chagas’ disease) in a sample rural population Province Nasca, Department Ica, southwestern Peru. Although Triatoma infestans, only vector species identified is often found domestic environments, data extent human T. are scant. This study comprised 446 houses, known to be infested triatomines, distributed 19 localities. While visiting those houses we collected filter paper bloodspots from 864 occupants (of...

A eficácia do controle da esquistossomose depende em grande parte sensibilidade coproscopia. Passamos a utilizar, além técnica de Kato-Katz, prensagem fezes entre lâmina e lamínula polipropileno, segundo Ferreira. De 1.282 amostras fecais colhidas 1998 2000 no Bairro Palha, Município Bananal, São Paulo, Brasil, 105 (8,2%) resultaram positivas. primeira revelou 90 (7%) segunda, 88 (6,9%) Os resultados concordaram, estatística kappa. Valores baixos percentagens positivos opg (ovos por grama)...

A critical role has been proposed for the switch from non-cytophilic IgG2 to cytophilic antibodies of IgG1 and IgG3 subclasses observed in humoral immune responses Plasmodium falciparum some Africans. These Africans have acquired clinically immunity naturally, after several years exposure holo-endemic malaria. In present study, possibility that life-long low levels malarial endemicity may be associated with changes IgG-subclass composition P. was investigated a native Amazonian community....

O Programa de Controle da Doença Chagas (PCDCh) no Estado São Paulo encontra-se na fase vigilância entomológica, submetendo a exames sorológicos os moradores unidades domiciliares (UDs), em que triatomíneos vetores tenham sido encontrados infectados por Trypanosoma cruzi. No decênio 1990-1999 foram trabalhadas localidades que, segundo graus infestações intra ou peridomicílio, desencadearam trabalhos rotina busca desses e atendimento notificações parte moradores. Em 1.415 UDs examinadas,...

Este estudo teve o objetivo de avaliar, em assentamentos e reassentamentos rurais, tendo conta seu tempo formação, características da infestação habitações por triatomíneos. Analisamos dados referentes a 48 pesquisas triatomíneos, colhidos durante período entre janeiro 1984 junho 2005, 105 seis do Pontal Paranapanema. Das 16 realizadas nos assentamentos, sete (43,8%) resultaram positivas. Todos os positivos haviam sido estabelecidos oito ou mais anos antes. 32 reassentamentos, 23 (71,9%)...

Between the years 1976 and 1980, American trypanosomiasis was searched for among residents in two geographic microregions of State São Paulo: Campos de Itapetininga, region Sorocaba, Encosta Ocidental da Mantiqueira Paulista, Campinas. Both areas have past been colonized by Triatoma infestans. Itapetininga remained, until beginning 1970s as a stronghold this species Paulo. Panstrongylus megistus has currently these areas, now classified having serological titer profiles characteristic low...

Atendendo a notificação de encontro, por habitantes da Fazenda Paraíso, área rural do Município Paulínia, Estado São Paulo, um exemplar alado triatomíneo, procedeu-se uma investigação epidemiológica em que capturaram-se 109 exemplares Triatoma infestans focos situados construções peridomiciliares. As condições locais favoreciam colonização triatomíneos: grande número peridomiciliares abandonadas, habitadas pombos e pardais, fornecedores farto alimento para os hemípteros. Eliminaram-se meio...

The Palha district, municipality of Bananal, State São Paulo, Brazil, had 10.3% cases Schistosoma mansoni diagnosed from 1994 to 2000 by coproscopy: about three times the average. immunofluorescent antibody test was used assess gut-associated IgM titers samples 452 inhabitants. It disclosed 129 (28.5%) positive cases. Subjects were classified according age, sex, birthplace, and period residence. Titers varied 8 4,096 (geometric mean: 170.2). Seropositives aged 6 69 years (average: 24.5), 75%...

We conducted monthly snail captures in Bananal, State of São Paulo, Brazil, between March 1998 and February 2001, to identify Schistosoma mansoni vectors, estimate seasonal population changes, delimit foci. also evaluated the impact improvements city water supply basic sanitation facilities. identified 28,651 vector specimens, 28,438 as Biomphalaria tenagophila, 49 them (0.2%) infected with S. mansoni, 213 B. straminea, none latter infected. Vectors predominated bodies having some vegetation...

The purpose of our study in the municipality Bananal, state São Paulo, Brazil, was to stop transmission schistosomiasis mansoni. Particular emphasis given such items as active surveillance and eventual treatment hosts, mapping parasite foci, increasing extent basic sanitation municipality. Now, records indicate that eradication Bananal is attainable. However, vector Biomphalaria tenagophila can still be found some water bodies within this municipality, it remains included area where endemic,...

The study is part of a project intended to retrieve information about the serology American trypanosomiasis in state São Paulo, Brazil, during period when there was effort control vector. Data from municipality Taquarituba, administrative region Sorocaba, which then important epidemiology Chagas disease that region, were analyzed. Despite government efforts started 1950s, domiciliary triatomines still being captured 1970s.Population samples selected five localities Taquarituba. Age, sex,...

Bananal is an important focus of Schistosoma mansoni in the State São Paulo. Accordingly, programmed active search for human cases, annual coproscopic surveys and treatment infected cases were started 1998, aiming at producing a sharp prevalence rate drop by year 2000. S. eggs searched two Kato-Katz slides per patient. Cases followed up according to routine local Family Health Program. In 130 samples out 3,860 showed eggs; 1999, 105 3,550, 2000, 64 3,528. Prevalence rates 3.4%, 2.9%, 1.8%,...