A5085981421- Cardiac, Anesthesia and Surgical Outcomes
- Amyotrophic Lateral Sclerosis Research
- Neurogenetic and Muscular Disorders Research
- Erythrocyte Function and Pathophysiology
- Nutrition and Health in Aging
- Aortic aneurysm repair treatments
- Hip and Femur Fractures
- Abdominal vascular conditions and treatments
- Vascular anomalies and interventions
- Parkinson's Disease Mechanisms and Treatments
- Hemoglobinopathies and Related Disorders
- Enhanced Recovery After Surgery
- Autophagy in Disease and Therapy
- Alzheimer's disease research and treatments
- Spinal Cord Injury Research
- Hospital Admissions and Outcomes
- Cardiac Structural Anomalies and Repair
- biodegradable polymer synthesis and properties
- Prion Diseases and Protein Misfolding
- Nanofabrication and Lithography Techniques
- Surgical Simulation and Training
- Dendrimers and Hyperbranched Polymers
- Cardiac Valve Diseases and Treatments
- Lysosomal Storage Disorders Research
- Rheology and Fluid Dynamics Studies
Hospitais da Universidade de Coimbra
1992-2024
University of Lisbon
2021-2023
Background Clinical studies are coordinated by multidisciplinary teams, which often lack adequate training and competencies. In this study, ROCHE AICIB (Agency for Research Biomedical Innovation) conducted a self-assessment survey aiming to evaluate the competency of clinical research professionals conduct in Portugal promote identification key actions address priority gaps. Methods from 10 Portuguese centres answered an electronic survey, adapted translated Joint Task Force Trial Competency...
Malaria remains a major world public health problem, contributing to poverty and inequality. It is urgent find new efficacious tools with few adverse effects. has selected red blood cell (RBC) alterations linked resistance against infection, understanding the protective mechanisms involved may be useful for developing host-directed control Plasmodium infection. Pyruvate kinase deficiency been associated malaria. kinase-deficient RBCs display an increased concentration of...
Erythrocytes play a fundamental role in oxygen delivery to tissues and binding inflammatory mediators. Evidences suggest that dysregulated erythrocyte function could contribute the pathophysiology of several neurodegenerative diseases. We aimed evaluate changes morphological, biomechanical, biophysical properties erythrocytes from amyotrophic lateral sclerosis (ALS) patients, as new areas study this disease. Blood samples were collected ALS comparing with healthy volunteers. assessed using...
Abstract Erythrocytes are deformable cells that undergo progressive biophysical and biochemical changes affecting the normal blood flow. Fibrinogen, one of most abundant plasma proteins, is a primary determinant for in haemorheological properties, major independent risk factor cardiovascular diseases. In this study, adhesion between human erythrocytes measured by atomic force microscopy (AFM) its effect observed micropipette aspiration technique, absence presence fibrinogen. These...
The reported superiority of mitral valve (MV) repair for isolated MV regurgitation has not been confirmed in mitroaortic surgery. Our goals were to evaluate the feasibility patients undergoing and aortic surgery identify factors predisposing replacement, compare long-term outcomes (survival reoperation) replacement perform a subgroup analysis with rheumatic disease.From January 1992 through December 2016, 1122 consecutive submitted concomitant 2 different centres (Coimbra Santiago). Of...
ABSTRACT In atherosclerotic lesions, vascular smooth muscle cells (VSMCs) represent half of the foam cell population, which is characterized by an aberrant accumulation undigested lipids within lysosomes. Loss lysosome function impacts VSMC homeostasis and disease progression. Understanding molecular mechanisms underlying dysfunction in these is, therefore, crucial. We identify cholesteryl hemiazelate (ChA), a stable oxidation end-product cholesteryl-polyunsaturated fatty acid esters, as...
Introduction: The benefits of the multimodal Enhanced Recovery After Surgery® (ERAS) program have been described all over world. adoption several perioperative strategies translates into an improvement in quality healthcare provided. aim this study was to report results implementation ERAS® for colorectal surgery a tertiary hospital.Material and Methods: In single-center observational study, 534 patients who underwent between December 2018 May 2021 were included. Two groups considered:...
Amyotrophic lateral sclerosis (ALS) is a devastating and fatal neurodegenerative disorder.Death typically occurs within 3–5 years after disease onset. The main cause of death in ALS respiratory failure (RF). No effective treatment available no molecular biomarker related to outcome early ventilatory dysfunction was described so far. club-cell protein (CC-16) associated with distress lung inflammation.The aim this work test if CC-16 IL-6 could be new biomarkers for signs insufficiency...
Amyotrophic lateral sclerosis (ALS) is an aggressive neurodegenerative disorder related to neuroinflammation that associated with increased risk of thrombosis. We aimed evaluate γ' fibrinogen plasma level (an in vivo variant fibrinogen) as a biomarker ALS, and test its role predictor disease progression survival. Sixty-seven consecutive patients ALS were followed the results compared those from 82 healthy blood donors. Patients clinically evaluated at time sampling on follow-up (every 3...
Superior mesenteric artery aneurysms (SMAA) are rare and associated with a high risk of rupture, morbidity mortality. Their clinical presentation is heterogeneous, turning the diagnosis into difficult task-which can delay their treatment. We present case patient SMAA, treated successfully coil embolization.