A5013008004- Obsessive-Compulsive Spectrum Disorders
- Amyotrophic Lateral Sclerosis Research
- Brazilian Legal Issues
- Neurogenetic and Muscular Disorders Research
- Stress Responses and Cortisol
- Neural and Behavioral Psychology Studies
- Parkinson's Disease Mechanisms and Treatments
- Public Health in Brazil
- Academic Research in Diverse Fields
- Autism Spectrum Disorder Research
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Cellular transport and secretion
- Psychology of Moral and Emotional Judgment
- Lysosomal Storage Disorders Research
- Neural dynamics and brain function
- Mental Health Research Topics
- Sphingolipid Metabolism and Signaling
- Medical Malpractice and Liability Issues
- Peripheral Neuropathies and Disorders
- Neurotransmitter Receptor Influence on Behavior
- Science and Science Education
- Spinal Cord Injury Research
- Personality Disorders and Psychopathology
- COVID-19 and Mental Health
- Neurological and metabolic disorders
University of Lisbon
2017-2023
Universidade Lusófona
2020
Instituto de Medicina Molecular João Lobo Antunes
2020
Abstract Background Chorea‐acanthocytosis (ChAc) is associated with mutations of VPS13A , which encodes for chorein, a protein implicated in lipid transport at intracellular membrane contact sites. Objectives The goal this study was to establish the lipidomic profile patients ChAc. Methods We analyzed 593 species caudate nucleus (CN), putamen, and dorsolateral prefrontal cortex (DLPFC) from postmortem tissues four ChAc six without Results found increased levels...
To identify serum sphingolipids that could act as candidate biomarkers in RA.We performed lipidomic analyses the of 82 participants: 19 established RA patients, 18 untreated early 13 arthritis patients not fulfilling classification criteria for RA, 12 SpA and 20 controls. We compared lipid levels from different patient groups with control group through multiple-regression controlling age at diagnosis, gender medication (cDMARDs corticoids).Established had significantly increased sphingosine,...
Acute stress is ubiquitous in everyday life, but the extent to which acute affects how people learn from outcomes of their choices still poorly understood. Here, we investigate impacts reward and punishment learning men using a reinforcement-learning task. Sixty-two male participants performed task whilst under control conditions. We observed that impaired participants' choice performance towards monetary gains, not losses. To unravel mechanism(s) underlying such impairment, fitted model...
Alterations in the levels of serum sphingolipids and phospholipids have been reported Gaucher disease Parkinson's disease, suggesting a potential role these lipids as biomarkers. This project's objective is to detect novel associations candidate biomarkers largest Spanish Parkinson diseases Iberian Peninsula. For that, 278 participants were included: 100 sporadic patients, 70 15 GBA1-mutation-carrier patients 93 controls. A lipidomics array including 10 phospholipid groups, 368 species, was...
Erythrocytes play a fundamental role in oxygen delivery to tissues and binding inflammatory mediators. Evidences suggest that dysregulated erythrocyte function could contribute the pathophysiology of several neurodegenerative diseases. We aimed evaluate changes morphological, biomechanical, biophysical properties erythrocytes from amyotrophic lateral sclerosis (ALS) patients, as new areas study this disease. Blood samples were collected ALS comparing with healthy volunteers. assessed using...
Acute stress is pervasive in everyday modern life and thought to affect how people make choices learn from them. Reinforcement learning, which implicates learning the unexpected rewarding punishing outcomes of our (i.e., prediction errors), critical for adjusted behaviour seems be affected by acute stress. However, neural mechanisms disrupts this type are still poorly understood. Here, we investigate whether blunts signalling errors during reinforcement using model-based functional magnetic...
In amyotrophic lateral sclerosis (ALS) lower plasma creatinine level has been associated with shorter survival and faster functional decline. It not clear if is respiratory outcome. We analyzed retrospectively a population of unselected ALS patients. Multiple-regression Cox-regression analyses were performed. included 233 patients, mean age 62.8, disease duration 18.6 months. At baseline, was significantly ALSFRS-R, but its decline rate. No predictive value disclosed for FVC, rate, or...
Amyotrophic lateral sclerosis (ALS) is an aggressive neurodegenerative disorder related to neuroinflammation that associated with increased risk of thrombosis. We aimed evaluate γ' fibrinogen plasma level (an in vivo variant fibrinogen) as a biomarker ALS, and test its role predictor disease progression survival. Sixty-seven consecutive patients ALS were followed the results compared those from 82 healthy blood donors. Patients clinically evaluated at time sampling on follow-up (every 3...
Individuals with high levels of psychopathic traits are often characterized by aberrant reinforcement learning. This type learning, which implicates making choices that maximize rewards and minimize punishments, may be affected acute stress. However, how stress affects learning in individuals different is not well-understood. Here, we investigated whether individual differences modulated the impact on reward punishment learning.Sixty-two male participants from a university sample completed...
Abstract Reinforcement learning, which implicates learning from the rewarding and punishing outcomes of our choices, is critical for adjusted behaviour. Acute stress seems to affect this ability but neural mechanisms by it disrupts type are still poorly understood. Here, we investigate whether how acute blunts signalling prediction errors during reinforcement using model-based functional magnetic resonance imaging. Male participants completed a well-established task involving monetary gains...
ABSTRACT Serotonin fosters cognitive flexibility, but how, exactly, remains unclear. We show that serotonin reduces belief stickiness: the tendency to get “stuck” in a about state of world despite incoming contradicting evidence. Participants performed task assessing stickiness randomized, double-blind, placebo-controlled study using single dose selective reuptake inhibitor (SSRI) escitalopram. In escitalopram group, higher plasma levels reduced more, resulting better inference world....