A5030161052- Parkinson's Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis B Virus Studies
- Genetic Neurodegenerative Diseases
- Tryptophan and brain disorders
- Lysosomal Storage Disorders Research
- Sleep and Wakefulness Research
- Neurogenesis and neuroplasticity mechanisms
- Child Development and Digital Technology
- Pituitary Gland Disorders and Treatments
- Advanced Glycation End Products research
- Cancer Immunotherapy and Biomarkers
- Adrenal Hormones and Disorders
- Neurological disorders and treatments
- Cancer, Stress, Anesthesia, and Immune Response
- Endoplasmic Reticulum Stress and Disease
- Cellular transport and secretion
- Neural dynamics and brain function
- Immune Response and Inflammation
- Neonatal and fetal brain pathology
- Single-cell and spatial transcriptomics
- Neuroendocrine regulation and behavior
University of Coimbra
2018-2023
Centro de Neurociências e Biologia Celular
2022
Massachusetts Institute of Technology
2020
McGovern Institute for Brain Research
2020
University of Lisbon
2014-2017
Association for Innovation and Biomedical Research on Light and Image
2013
Universidade de São Paulo
1999
α-Synuclein misfolding and aggregation is a hallmark in Parkinson's disease several other neurodegenerative diseases known as synucleinopathies. The toxic properties of α-synuclein are conserved from yeast to man, but the precise underpinnings cellular pathologies associated still elusive, complicating development effective therapeutic strategies. Combining molecular genetics with target-based approaches, we established that glycation, an unavoidable age-associated post-translational...
Parkinson's disease (PD) is a progressive neurodegenerative disorder known for the typical motor features associated. Pathologically, it characterized by intracellular accumulation of alpha-synuclein (aSyn) in Lewy bodies and neurites. Currently, there are no established biochemical markers diagnosing or following progression, major limitation clinical practice. Posttranslational modifications (PTMs) aSyn have been identified implicated on its pathobiology. Since abundant blood erythrocytes,...
Interleukin-4 (IL-4) is a type 2 cytokine with pleiotropic functions in adaptive immunity, allergies, and cognitive processes. Here, we show that low levels of IL-4 the early postnatal stage delineate critical period which microglia extensively prune cerebellar neurons. Elevating this via peripheral injection, or using mouse model allergic asthma, leads to defective pruning, permanent increase granule cells, circuit alterations. These animals also hyperkinetic impulsive-like phenotype,...
Abstract Protein glycation is an age-dependent posttranslational modification associated with several neurodegenerative disorders, including Alzheimer’s and Parkinson’s diseases. By modifying amino-groups, interferes folding of proteins, increasing their aggregation potential. Here, we studied the effect pharmacological genetic manipulation on huntingtin (HTT), causative protein in Huntington’s disease (HD). We observed that increased mutant HTT exon 1 fragments HD (HTT72Q HTT103Q) yeast...
Hepatocellular carcinoma is the fifth most common cancer in men and seventh women, as diagnosed more than half a million individuals worldwide every year. In Portugal, its incidence mortality rates are low compared to other types of cancers. Brazil, city São Paulo, according data released by Brazilian Unified Health System (Sistema Único de Saúde – SUS), primary liver was 2.07/100,000 inhabitants. Although vast majority cases (85%) mainly affect developing countries, especially where...
Colorectal cancer (CRC) is the second most frequent and fatal in Western countries. Understanding its biology with different incidence along colon rectum, genetic profile how these factors contribute to local/distant progression, has been hampered by lack of a suitable CRC model. We report reproducible model, using human cell lines (CL) (WiDr, LS1034, C2BBe1) injected (1 × 107 cells/animal) RNU rats (n = 55) which underwent cecostomy descending colostomy mucosal-cutaneous fistula sigmoid...
<h3></h3> Glycation, an age-dependent posttranslational protein modification, has been reported in several neurodegenerative disorders, including Alzheimer’s and Parkinson’s disease. This non-enzymatic reaction between reducing sugars free amino-groups from proteins, interferes with the aggregation process of proteins such as amyloid-beta alpha-synuclein. As methylglyoxal (MGO) is most important glycation agent, here we interrogated whether MGO could also play a role huntingtin (HTT)...
Abstract Background Autism Spectrum Disorders (ASDs) are known to present sex-specific differences. Understanding how maternal behaviours affected by pathogenic mutations is crucial translate research efforts, since rearing may recursively modulate neurodevelopment phenotype of the progeny. In this work, we focused on effects Gprasp2 deletion in females and its impact progeny care development. Methods Female mice, wild-type (WT), +/- (HET) or -/- (KO) mutants their were used. Behavioural...
SummaryInterleukin-4 (IL-4) is a Th2 cytokine with pleiotropic functions in adaptive immunity, allergies, and cognitive processes. We now show that low levels of IL-4 the early postnatal stage delineate critical period which microglia extensively prune cerebellar neurons. Elevating this via peripheral injection, or using mouse model allergic asthma, leads to defective pruning, permanent increase granule cells, circuit alterations. These animals also hyperkinetic impulsive-like phenotype,...