A5002392174- Multiple Myeloma Research and Treatments
- Chronic Lymphocytic Leukemia Research
- Acute Myeloid Leukemia Research
- Autism Spectrum Disorder Research
- Hematopoietic Stem Cell Transplantation
- Histone Deacetylase Inhibitors Research
- Advanced biosensing and bioanalysis techniques
- Antifungal resistance and susceptibility
- Lysosomal Storage Disorders Research
- Genetics and Neurodevelopmental Disorders
- Lymphoma Diagnosis and Treatment
- Neuroendocrine regulation and behavior
- Fungal Infections and Studies
- Immunotherapy and Immune Responses
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- RNA modifications and cancer
- HIV/AIDS drug development and treatment
- Retinoids in leukemia and cellular processes
- Soft tissue tumor case studies
- Nerve injury and regeneration
- Protein Degradation and Inhibitors
- Chemokine receptors and signaling
- Oral and Maxillofacial Pathology
- Ferroptosis and cancer prognosis
- Hemoglobinopathies and Related Disorders
University of Coimbra
2010-2024
Hospitais da Universidade de Coimbra
2008-2024
i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto
2023
Faculty (United Kingdom)
2019
Centro de Neurociências e Biologia Celular
2019
Universidade do Porto
2015
Abstract Autism spectrum disorder (ASD) is characterized by dysfunction in social interactions, stereotypical behaviours and high co-morbidity with intellectual disability. A variety of syndromic non-syndromic neurodevelopmental disorders have been connected to alterations metabotropic glutamate receptor (mGluR) signalling. These receptors contribute synaptic plasticity, spine maturation circuit development. Here, we investigate the physiological role Gprasp2 , a gene linked disabilities...
Interleukin-4 (IL-4) is a type 2 cytokine with pleiotropic functions in adaptive immunity, allergies, and cognitive processes. Here, we show that low levels of IL-4 the early postnatal stage delineate critical period which microglia extensively prune cerebellar neurons. Elevating this via peripheral injection, or using mouse model allergic asthma, leads to defective pruning, permanent increase granule cells, circuit alterations. These animals also hyperkinetic impulsive-like phenotype,...
Notwithstanding the advances in treatment of lung cancer with immune checkpoint inhibitors, high percentage non-responders supports development novel anticancer treatments. Herein, expression onco-target nucleolin patient-derived pulmonary carcinomas was characterized, along assessment its potential as a therapeutic target. The clinical prognostic value for human evaluated through data mining from Cancer Genome Atlas project and immunohistochemical detection samples. Cell surface by flow...
Autism spectrum disorders (ASDs) are known to present sex-specific differences. At the same time, understanding how maternal behaviours affected by pathogenic mutations is crucial translate research efforts since rearing may recursively modulate neurodevelopment phenotype of progeny. In this work, we focused on effects Gprasp2 deletion in females and its impact progeny care development. Female mice, wild-type (WT),
In Krabbe disease (KD), mutations in β-galactosylceramidase (GALC), a lysosomal enzyme responsible for the catabolism of galactolipids, leads to accumulation its substrates galactocerebroside and psychosine. This neurologic condition is characterized by severe progressive demyelination together with neuron-autonomous defects degeneration. Twitcher mice mimic infantile form KD, which most common human disease. The CNS PNS present demyelination, axonal loss neuronal including decreased levels...
Hodgkin's variant of Richter transformation is a rare complication chronic lymphocytic leukemia and associated with inferior outcomes compared to de novo Hodgkin lymphoma. Further data concerning prognosis treatment occurring in the setting novel targeted therapies are needed.
Effective clearance rates of HCV with interferon alpha plus ribavirin treatment are reported to be reduced in the co‐infected HIV/HCV population when compared monoinfected [ 1 ]. Neuropsychiatric adverse events associated hepatitis C and alpha‐induced major depressive disorder is commonly 2 This study examined rate predictors depression during a Brighton, UK cohort HCV‐infected patients including subsample HIV coinfection. Depressive was explored at baseline monthly up 6 months using...
Background: Daratumumab (Dara) is a monoclonal antibody (mAb) directed against CD38, that extensively expressed on plasma cells, but also in adipocytes, being an important determinant for adipose tissue differentiation. Some studies revealed lower serum levels of mAb overweight (OW) pts, with decreased efficacy. Besides that, the best method to establish dosage debated–actual body weight (ABW), surface area (BSA) or fixed dosing (FD). Because there probability Dara‐adipocyte interaction, and...
Topic: 4. Acute myeloid leukemia - Clinical Background: (AML) with mutated Nucleophosmin-1 (NPM1MT) occurs in approximately 30% of patients (pts) AML and usually carries a better prognosis. However, the positive prognostic impact NPM1MT does not seem to extend elderly pts. Aims: To analyse age clinical characteristics, outcomes, prognosis pts NPM1MT. Methods: Retrospective, single-centre study 41 AML-NPM1MT diagnosed between jan/2015 jul/2022. Clinical, cytogenetic molecular data at...
Abstract In Krabbe disease (KD), mutations in β-galactosylceramidase (GALC), a lysosomal enzyme responsible for the catabolism of galactolipids, lead to accumulation its substrates galactocerebroside and psychosine. This neurologic condition is characterized by severe progressive demyelination together with neuron-autonomous defects degeneration. Twitcher mice mimic infantile form KD, which most common human disease. The CNS PNS present demyelination, axonal loss neuronal including decreased...
Topic: 4. Acute myeloid leukemia - Clinical Background: (AML) with mutated Nucleophosmin-1 (NPM1) usually carries a better prognosis, being associated favorable response to standard intensive chemotherapy (IC). However, the impact of additional molecular and cytogenetic alterations on incited redefining AML risk classification by European LeukemiaNet (ELN). Aims: To compare prognostic ELN2017 ENL2022 in real-life cohort. Methods: Retrospective, single-centre study 41 AML-NPM1 pts diagnosed...
Topic: 4. Acute myeloid leukemia - Clinical Background: Nucleolin (NCL) is a nucleolar phosphoprotein involved in DNA repair, ribosomal biogenesis, and mRNA metabolism, localized to the nucleolus through its interaction with Nucleophosmin (NPM). NCL NPM shuttle between nucleoli cytoplasmic membrane, as protein chaperones. Cellular stress leads translocation of cytoplasm heterotopic overexpression acute (AML) blasts. C-terminal NPM1 mutations – conferring favorable prognosis (Px) AML cause...