A5011634437- Research on Leishmaniasis Studies
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Synthesis and Biological Evaluation
- Advancements in Transdermal Drug Delivery
- Trypanosoma species research and implications
- Advanced Drug Delivery Systems
- Nanoparticle-Based Drug Delivery
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Toxin Mechanisms and Immunotoxins
- SARS-CoV-2 detection and testing
- RNA modifications and cancer
- Synthesis and Characterization of Heterocyclic Compounds
- Autism Spectrum Disorder Research
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Landfill Environmental Impact Studies
- Health Education and Validation
- Drug Solubulity and Delivery Systems
- Family and Disability Support Research
- Cannabis and Cannabinoid Research
- Electrical and Bioimpedance Tomography
- Biochemical Acid Research Studies
- Surfactants and Colloidal Systems
- Lipid Membrane Structure and Behavior
University College London
2020-2024
St Mark's Hospital
2024
University of Coimbra
2012-2021
University College Lahore
2020
University of Lisbon
2009-2015
National Institute of Engineering, Technology and Innovation
2005
Abstract There are currently no cures for coronavirus infections, making the prevention of infections only course open at present time. The COVID-19 pandemic has been difficult to prevent, as infection is spread by respiratory droplets and thus effective, scalable safe preventive interventions urgently needed. We hypothesise that preventing viral entry into mammalian nasal epithelial cells may be one way limit COVID-19. Here we show...
Main-stay in treatment of leishmaniasis relies on chemotherapy but none the current drugs combines high activity and low toxicity at affordable costs. Dinitroanilines are a new class with proved vitro antileishmanial activity. However development their pharmaceutical formulations has been compromised by water solubility accumulation diseased organs. These limitations can be overcome incorporation lipid-based nanoformulations such as liposomes solid lipid nanoparticles. In previous work this...
This work aims at developing and optimizing a valuable oral delivery carrier for the cannabinoid derivative CB13, which presents high therapeutic potential in chronic pain states that respond poorly to conventional analgesics, but also shows highly unfavorable physicochemical properties. CB13-loaded lipid nanoparticles (LNP) formulations were developed through solvent-emulsion evaporation optimized terms of properties, long-term stability, integrity under gastric simulated conditions vitro...
The administration of lipid nanoparticles (LNP) by different routes involves technological challenges, particularly those associated with sterilization and stability. Publications suggest that the stability LNP formulations throughout harsh production conditions involved in pharmaceutical procedures is highly dependent on type surfactant used. Therefore, capacity tripalmitin‐based to withstand moist heat freeze‐drying has been evaluated using poly (vinyl alcohol), soya lecithin, polysorbate...
Levodopa (L-DOPA) is an oral Parkinson's Disease drug that generates the active metabolite - dopamine (DA) in vivo. However, L-DOPA exhibits low bioavailability, limited brain uptake, peripheral DA-mediated side effects and its poor bioavailability can lead to long-term complications. Here we show forms stable (for at least 5 months) 300 nm nanoparticles when encapsulated within N-palmitoyl-N-monomethyl-N,N-dimethyl-N,N,N-trimethyl-6-O-glycolchitosan (GCPQ). A nano-in-microparticle...
To improve the potential of trifluralin (TFL) in management Leishmania infantum infections through synthesis analogs (TFLA) and incorporation nanoparticulate drug delivery systems (NanoDDS), liposomes solid lipid nanoparticles, for selective targeting to leishmania infection sites.In vitro screening 18 TFLA was performed by flow cytometry. NanoDDS were loaded with active evaluated antileishmanial efficacy mice determination parasite burden liver spleen.The testing revealed most nontoxic...
Abstract There are currently no cures for coronavirus infections, making the prevention of infections only course open at present time. The COVID-19 pandemic has been difficult to prevent, as infection is spread by respiratory droplets and thus effective, scalable safe preventive interventions urgently needed. We hypothesise that preventing viral entry into mammalian nasal epithelial cells may be one way limit COVID-19. Here we show...
Este estudo bibliográfico examinou a Aprendizagem Baseada em Problemas (ABP) como metodologia ativa no contexto do suporte educacional para estudantes com Transtorno Espectro Autista (TEA), focando suas estratégias e benefícios potencializar o processo de ensino-aprendizagem. A pesquisa analisou literatura atual sobre tema, investigando aplicação da ABP ensino alunos TEA, seus desafios possibilidades. Os achados sugerem que pode promover significativamente desenvolvimento habilidades...
Abstract A multiphase Volume‐of‐fluid (VOF) model was developed to gain further insights into the reactive flow parameters and electrical capacitance tomography (ECT) measurements on remediation of hazardous organic pollutants. Low ozone bubble frequencies were obtained for high surface tension fluids, liquid viscosity affected bubbling frequency. The VOF indicated that increase inlet gas velocity enriched detachment concomitantly generated larger bubbles, decreasing detoxification rates....