A5023523642- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Inhalation and Respiratory Drug Delivery
- Nanoplatforms for cancer theranostics
- Advanced Drug Delivery Systems
- Radiopharmaceutical Chemistry and Applications
- Lipid Membrane Structure and Behavior
- Microencapsulation and Drying Processes
- Computational Drug Discovery Methods
- Natural Antidiabetic Agents Studies
- Pharmacological Effects of Natural Compounds
- Advancements in Transdermal Drug Delivery
- Protein Tyrosine Phosphatases
- Organ Transplantation Techniques and Outcomes
- Metal complexes synthesis and properties
- Advanced biosensing and bioanalysis techniques
- Characterization and Applications of Magnetic Nanoparticles
- Vitamin C and Antioxidants Research
- Graphene and Nanomaterials Applications
- Rheumatoid Arthritis Research and Therapies
- Chemical Reactions and Isotopes
- Microfluidic and Capillary Electrophoresis Applications
- Biochemical Acid Research Studies
- Atherosclerosis and Cardiovascular Diseases
- Drug Solubulity and Delivery Systems
University of Lisbon
2016-2025
Instituto Politécnico de Lisboa
2017-2020
Rede de Química e Tecnologia
2008
Universidade do Porto
2008
National Institute of Engineering, Technology and Innovation
1997-2006
Utrecht University
1997-1999
Acute gastric mucosal injury is a common disorder of the gastrointestinal tract and search for new therapeutics ongoing. The aim this study to update expand information related most widely used rat models acute ulcer, ethanol-induced ulcer indomethacin-induced ulcer. These two are compared in terms macroscopic microscopic features. Experimentally, ethanol was given orally single dose indomethacin subcutaneously injected into male Wistar rats. After ulcerative challenges, stomachs were...
Ischemia and reperfusion injury (IRI) is a common complication caused by inflammation oxidative stress resulting from liver surgery. Current therapeutic strategies do not present the desirable efficacy, severe side effects can occur. To overcome these drawbacks, new alternatives are necessary. Drug delivery nanosystems have been explored due to their capacity improve index of conventional drugs. Within nanocarriers, liposomes one most successful, with several formulations currently in...
In type 2 diabetes mellitus, hepatic insulin resistance is intricately associated with oxidative stress and inflammation. Nonetheless, the lack of therapeutic interventions directly targeting dysfunction represents a notable gap in current treatment options. Flavonoids have been explored due to their potential antidiabetic effects. However, these compounds are low bioavailability high metabolization. present study, four flavonoids, kaempferol, quercetin, kaempferol-7-O-glucoside...
Nitroaromatic-based triazene prodrugs elicited enhanced cytotoxicity and apoptosis in hypoxic LN-229 glioblastoma cells comparing to temozolomide, highlighting their therapeutic potential for multiforme.
Although silver nanoparticles (AgNPs) are widely disseminated and show great potential in the biomedical field, there is a recognized need to better understand their action at metabolic functional levels. In this work, we have used NMR metabolomics, together with conventional clinical chemistry histological examination, characterize multi-organ systemic responses AgNPs intravenously administered mice 8 mg/kg body weight (a dose not eliciting overt toxicity). The major target organs of...
Here, a continuous two-step glass-capillary microfluidic technique to produce multistage oral insulin delivery system is reported. This represents promising alternative for the common protein/peptide-loaded liposome formulations.
Resistance to chemotherapy is a major problem facing current cancer therapy, which continuously aiming at the development of new compounds that are capable tackling tumors developed resistance toward common chemotherapeutic agents, such as doxorubicin (DOX). Alongside generations compounds, nanotechnology-based delivery strategies can significantly improve in vivo drug stability and target specificity for overcoming resistance. In this study, multifunctional gold nanoparticles (AuNP) have...