A5021712415- Bipolar Disorder and Treatment
- Schizophrenia research and treatment
- Neurotransmitter Receptor Influence on Behavior
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Mental Health and Psychiatry
- Electroconvulsive Therapy Studies
- Treatment of Major Depression
- Hepatitis C virus research
- Pharmaceutical studies and practices
- Electrolyte and hormonal disorders
- Psychiatric care and mental health services
- Liver Disease Diagnosis and Treatment
- Pituitary Gland Disorders and Treatments
- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- Receptor Mechanisms and Signaling
- Natural Compound Pharmacology Studies
- Hormonal Regulation and Hypertension
- Sleep and Wakefulness Research
- Obsessive-Compulsive Spectrum Disorders
- Growth Hormone and Insulin-like Growth Factors
- Mental Health Treatment and Access
- Mental Health Research Topics
- Child and Adolescent Psychosocial and Emotional Development
Brighton and Sussex Medical School
2015-2024
Sussex Partnership NHS Foundation Trust
2015-2024
University of Sussex
2021
Whale Museum
2021
University of South Wales
2010
University College Hospital
2010
University College London
2010
Mill View Hospital
2010
Leeds General Infirmary
2009
University of Brighton
2006
Evidence for the effectiveness of treatments in early-onset psychosis is sparse. Current guidance treatment mostly extrapolated from trials adult populations. The UK National Institute Health and Care Excellence has recommended evaluation clinical cost-effectiveness antipsychotic drugs versus psychological intervention (cognitive behavioural therapy [CBT] family intervention) combination these psychosis. aim this study was to establish feasibility a randomised controlled trial monotherapy,...
Background Neuroendocrine studies of brain serotonin (5-HT) function in depression generally show evidence impaired 5-HT but it is disputed whether or not this impairment resolves with clinical recovery. Aims To use the endocrine response to selective 5-HTreuptake inhibitor, citalopram, study acute and recovered depressed subjects relative healthy controls. Method We used a double-blind, placebo-controlled design measure prolactin cortisol responses citalopram (10 mg intravenously) patients...
One year of antipsychotic treatment from symptom remission is recommended following a first episode psychosis (FEP).To investigate the effectiveness commonly used medications in FEP.A retrospective cohort study naturalistic patients (N=460) accepted by FEP services across seven UK sites. Treatment initiation to all-cause discontinuation determined case files.Risk greatest within 3 months initiation. Risperidone had longest median survival time. No significant differences were observed time...
Antipsychotic long-acting injectable (LAI) medication has an important place as a treatment option in schizophrenia with evolving evidence to support clinical benefit over oral medication. Paliperidone palmitate is recently licensed LAI. We studied naturalistic cohort of all identifiable patients who initiated paliperidone LAI specific United Kingdom region (Sussex) from first availability up January 2013 (n = 179). Favorably, 60% the continued beyond 12 months initiation. Schizophrenia...
Acute tryptophan depletion (ATD) decreases levels of central serotonin. ATD thus enables the cognitive effects serotonin to be studied, with implications for understanding psychiatric conditions, including depression.To determine role in conscious (explicit) and unconscious/incidental processing emotional information.A randomized, double-blind, cross-over design was used 15 healthy female participants. Subjective mood recorded at baseline after 4 h, when participants performed an explicit...
Background Brain serotonin (5-HT) function is abnormal in major depression, but the involvement of different 5-HT receptor subtypes has been little studied. The availability selective ligands now makes it possible to test sensitivity 1D receptors patients with depression. Aims aim study was use agonist, zolmitriptan, depression before and after treatment reuptake inhibitors (SSRIs). Method We measured growth hormone response zolmitriptan (5 mg orally) SSRI treatment. A matched sample healthy...
Summary Remission is a new research outcome indicating long-term wellness. not only sets standard for minimal severity of symptoms and signs (resolution); it also how long need to remain at this level (6 months). Individuals who achieve remission from schizophrenia have better subjective well-being functional outcomes than those do not. Research suggests that can be achieved in 20–60% people with schizophrenia. There some evidence the usefulness as an indicator clinicians, service users...
When psychosis emerges in young people there is a risk of poorer outcomes, and access to evidence-based treatments paramount. The current evidence base limited. Antipsychotic medications show only small benefit over placebo, but experience more side effects than adults. There sparse for psychological intervention. Research needed determine the clinical effectiveness cost-effectiveness intervention versus antipsychotic medication combined treatment adolescents with psychosis.