A5060851142- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Immune Response and Inflammation
- Neurogenesis and neuroplasticity mechanisms
- Neonatal and fetal brain pathology
- Olfactory and Sensory Function Studies
- Stress Responses and Cortisol
University of Coimbra
2022-2024
Centro de Neurociências e Biologia Celular
2022
Interleukin-4 (IL-4) is a type 2 cytokine with pleiotropic functions in adaptive immunity, allergies, and cognitive processes. Here, we show that low levels of IL-4 the early postnatal stage delineate critical period which microglia extensively prune cerebellar neurons. Elevating this via peripheral injection, or using mouse model allergic asthma, leads to defective pruning, permanent increase granule cells, circuit alterations. These animals also hyperkinetic impulsive-like phenotype,...
Microglia are crucial for brain development and their function can be impacted by postnatal insults, such as early-life allergies. These characterized an upregulation of interleukin (IL)-4 levels. Allergies share a strong comorbidity with Autism Spectrum Disorders (ASD) Attention-Deficit/Hyperactivity Disorder (ADHD). We previously showed that allergic asthma induces hyperactive impulsive behaviors in mice. This phenotype was reproduced animals administered IL-4 the second week....
SummaryInterleukin-4 (IL-4) is a Th2 cytokine with pleiotropic functions in adaptive immunity, allergies, and cognitive processes. We now show that low levels of IL-4 the early postnatal stage delineate critical period which microglia extensively prune cerebellar neurons. Elevating this via peripheral injection, or using mouse model allergic asthma, leads to defective pruning, permanent increase granule cells, circuit alterations. These animals also hyperkinetic impulsive-like phenotype,...