A5101932674- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Hormonal Regulation and Hypertension
- Genomics, phytochemicals, and oxidative stress
- Cardiovascular Disease and Adiposity
- Galectins and Cancer Biology
- Advanced Nanomaterials in Catalysis
- Glycogen Storage Diseases and Myoclonus
- Peer-to-Peer Network Technologies
- Pharmacovigilance and Adverse Drug Reactions
- Malaria Research and Control
- Caveolin-1 and cellular processes
- Hydrogels: synthesis, properties, applications
- Mosquito-borne diseases and control
- Corrosion Behavior and Inhibition
- Nerve injury and regeneration
- Long-Term Effects of COVID-19
- Magnetic Properties of Alloys
- Trypanosoma species research and implications
- Advanced Drug Delivery Systems
- Signaling Pathways in Disease
- Apelin-related biomedical research
- Protease and Inhibitor Mechanisms
- Advanced Photocatalysis Techniques
- Magnetic Properties and Synthesis of Ferrites
- ATP Synthase and ATPases Research
Universidade de Ribeirão Preto
2019-2024
Universidade de São Paulo
2019-2024
Swedish Institute
2022
Karolinska Institutet
2022
Karolinska University Hospital
2022
British Heart Foundation
2020
University of Glasgow
2020
Instituto de Investigación Sanitaria de Santiago
2018
Universidade do Porto
2015-2017
European Organization for Nuclear Research
2010
The cytokine storm in SARS-CoV-2 infection contributes to the onset of inflammation and target-organ damage. endothelium is a key player COVID-19 pathophysiology it an important target for cytokines. Considering that cytokines trigger oxidative stress negatively impact endothelial cell function, we sought determine whether serum from individuals with severe decreases cells' main antioxidant defense, i.e., transcriptional factor Nrf2. Human umbilical vein cells (HUVECs) were incubated...
Abstract Perivascular adipose tissue (PVAT) negatively regulates vascular muscle contraction. However, in the context of obesity, PVAT releases vasoconstrictor substances that detrimentally affect function. A pivotal player this scenario is peptide endothelin-1 (ET-1), which induces oxidative stress and disrupts The present study postulates obesity augments ET-1 production PVAT, decreases function nuclear factor erythroid 2-related factor-2 (Nrf2) transcription factor, further increasing...
Vascular smooth muscle cell (VSMC) function is regulated by Nox-derived reactive oxygen species (ROS) and redox-dependent signaling in discrete cellular compartments. Whether cholesterol-rich microdomains (lipid rafts/caveolae) are involved these processes unclear. Here we examined the sub-cellular compartmentalization of Nox isoforms lipid rafts/caveolae assessed role VSMC ROS production pro-contractile growth signaling. Intact small arteries primary VSMCs from humans were studied. Vessels...
Chikungunya virus (CHIKV) infection is characterized by febrile illness, severe joint pain, myalgia, and cardiovascular complications. Given that CHIKV stimulates reactive oxygen species (ROS) pro- anti-inflammatory cytokines, events disrupt vascular homeostasis, we hypothesized induces arterial dysfunction directly impacting redox-related mechanisms in cells. Wild-type (WT) iNOS knockout (iNOS−/−) mice were administered either (1.0 × 106 PFU/µL) or Mock vehicle via the intracaudal route. In...
High levels of aldosterone (Aldo) trigger oxidative stress and vascular dysfunction independent effects on blood pressure. We sought to determine whether Aldo disrupts Nrf2 signaling, the main transcriptional factor involved in antioxidant responses that aggravate cell injury. Thoracic aorta from male C57Bl/6J mice cultured human endothelial cells (EA.hy926) were stimulated with (100 nM) presence tiron [reactive oxygen species (ROS) scavenger, eplerenone [mineralocorticoid receptor (MR)...
Instrumentation of jobs throughout its life-cycle is not obvious, as they are quite independent after being submitted, crossing multiple environments and locations until landing on a worker node. In order to measure correctly the resources used at each step, compare it with view from Fabric Infrastructure, solution proposed using Messaging System for Grids (MSG) integrating information coming different sources.
Hyperaldosteronism (HA), characterized by the independent overproduction of aldosterone (Aldo), leads to cardiovascular damage and perivascular adipose tissue (PVAT) dysfunction. Beclin-1 (Becn1) is a key protein regulating autophagy, recycling process unwanted components. Whether HA disturbs autophagic flux in PVAT via Becn1 unknown. Thus, we hypothesize that Becn1-dependent will improve function inhibit genesis hypertension (HTN) HA. 10-12-weeks-old male C57BL/6J (WT) or knock-in mice...
Obesity triggers functional changes in the perivascular adipose tissue (PVAT), favoring release of vasoconstrictor factors and activation contractile mechanisms vascular smooth muscle cells. In PVAT obese individuals, there is infiltration immune cells, including neutrophils. A neutrophil defense mechanism formation extracellular traps (NETs), a cytotoxic framework that allows maintenance expansion inflammatory processes. We hypothesize dysfunction mice due to increased infiltration, NETs...
Abstract Rationale: Mucopolysaccharidosis type VI (MPS VI) or Maroteaux-Lamy syndrome is produced by the deficiency of enzyme arylsulfatase B, responsible for hydrolysis N-acetyl-D-galactosamine, chondroitin sulfate, and dermatan sulfate. Patient concerns: A 3-year-old male with Moroccan origins index case. He had healthy consanguineous parents 4 brothers sisters. The patient showed a wide spectrum symptoms including skeletal dysplasia short stature elevated glycosaminoglycans (GAGs) in...
Hyperaldosteronism (HA), characterized by an autonomous production of aldosterone, promotes increased blood pressure and cardiovascular damage. The perivascular adipose tissue (PVAT) participates the control vascular function is inflamed in HA. Autophagy a recycling process unnecessary or dysfunctional components it important for inflammatory tolerance, but whether autophagic flux dysregulated PVAT during HA, which would contribute to inflammation dysfunction this tissue, still be...
Abstract The glycosylation with O -linked- N -acetylglucosamine ( -GlcNAc) is an enzymatic process found on nuclear and cytoplasmic proteins. Augmented levels of -GlcNAc-modified proteins have been associated to cardiovascular disease (CD) in male. However, the association -GlcNAc CD females it’s not understood. Increased risk women linked menopause occurs about 10 years later than men. We tested hypothesis that aging promotes vascular dysfunction, which aggravated by augmented -GlcNAc. used...
Abstract Introduction Chronic increases in aldosterone (Aldo) levels (hyperaldosteronism) blood pressure and induces hypertension. In the cardiovascular system, Aldo stimulates reactive oxygen species (ROS) generation. ROS contribute to vascular dysfunction by increasing smooth muscle contractile tone, among other effects. Nuclear factor erythroid 2–related 2 (Nrf2), it’s one of main factors adaptive response oxidative stress. Hypothesis negatively regulates antioxidant system Nrf2, favoring...