A5060174671- COVID-19 Clinical Research Studies
- Cardiovascular Disease and Adiposity
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Sexual function and dysfunction studies
- Erythrocyte Function and Pathophysiology
- Spaceflight effects on biology
- Urinary Bladder and Prostate Research
- Adipose Tissue and Metabolism
- Hormonal Regulation and Hypertension
- Eicosanoids and Hypertension Pharmacology
- Inflammasome and immune disorders
- Exercise and Physiological Responses
- Diverticular Disease and Complications
- Adipokines, Inflammation, and Metabolic Diseases
- Atherosclerosis and Cardiovascular Diseases
- Effects and risks of endocrine disrupting chemicals
- Chemical Safety and Risk Management
- Medicinal Plants and Bioactive Compounds
- Inflammatory Bowel Disease
- Birth, Development, and Health
- Antioxidant Activity and Oxidative Stress
- Cholesterol and Lipid Metabolism
- Carcinogens and Genotoxicity Assessment
- Heart rate and cardiovascular health
- Eosinophilic Esophagitis
Universidade de São Paulo
2020-2024
University of South Carolina
2024
Universidade de Ribeirão Preto
2022-2024
Hospital da Senhora da Oliveira Guimarães
2023
Clinics Hospital of Ribeirão Preto
2022
Universidade São Francisco
2017-2021
Universidade Estadual de Campinas (UNICAMP)
2020
Universidade Católica de Pelotas
2008
Abstract Background The release of neutrophil extracellular traps (NETs) is associated with inflammation, coagulopathy, and organ damage found in severe cases COVID-19. However, the molecular mechanisms underlying NETs COVID-19 remain unclear. Objectives We aim to investigate role Gasdermin-D (GSDMD) pathway on development during Methods performed a single-cell transcriptome analysis public data bronchoalveolar lavage. Then, we enrolled 63 hospitalized patients moderate analyze blood lung...
Abstract Visceral adiposity is a risk factor for severe COVID-19, and link between adipose tissue infection disease progression has been proposed. Here we demonstrate that SARS-CoV-2 infects human undergoes productive in fat cells. However, susceptibility to the cellular response depends on anatomical origin of cells viral lineage. express more ACE2 are susceptible than their subcutaneous counterparts. leads inhibition lipolysis cells, while visceral it results higher expression...
Occurrence of hyperglycemia upon infection is associated with worse clinical outcome in COVID-19 patients. However, it still unknown whether SARS-CoV-2 directly triggers hyperglycemia. Herein, we interrogated and how causes by infecting hepatocytes increasing glucose production. We performed a retrospective cohort study including patients that were admitted at hospital suspicion COVID-19. Clinical laboratory data collected from the chart records daily blood values analyzed to test hypothesis...
± 3.85).In addition, we evaluated the possible association between creatine levels, smoking, alcohol intake, age, duration of treatment, and incomes individuals (separately analyzed according to their gender) frequency micronuclei.The results reported here indicate that treatment is only factor associated with increased MNC among hemodialysis patients (Spearman coefficient 0.414, P = 0.01).The number found in six years or less was significantly lower (2.91 2.74) compared seven more (8.89...
The aim of the study was to evaluate effects supplementation with glucosyl hesperidin (GH), or without physical training, on body weight, fat depot, glucose and plasma lipids, oxidative status vascular function rats fed high-fat diet (HFD).After weaning, male Wistar were an HFD plus fructose for 12 weeks started receiving oral antioxidant and/or training after fourth week eight further weeks. Body epididymal retroperitoneal fat, mesenteric artery reactivity evaluated.Rats presented higher...
Abstract The release of neutrophil extracellular traps (NETs) is associated with inflammation, coagulopathy, and organ damage found in severe cases COVID-19. However, the molecular mechanisms underlying NETs COVID-19 remain unclear. Using a single-cell transcriptome analysis we observed that expression GSDMD inflammasome-related genes were increased neutrophils from patients. Furthermore, high was structures lung tissue activation requires live SARS-CoV-2 occurs after infection via ACE2...
Hyperaldosteronism (HA), characterized by the independent overproduction of aldosterone (Aldo), leads to cardiovascular damage and perivascular adipose tissue (PVAT) dysfunction. Beclin-1 (Becn1) is a key protein regulating autophagy, recycling process unwanted components. Whether HA disturbs autophagic flux in PVAT via Becn1 unknown. Thus, we hypothesize that Becn1-dependent will improve function inhibit genesis hypertension (HTN) HA. 10-12-weeks-old male C57BL/6J (WT) or knock-in mice...
Background: Erectile dysfunction (ED) is largely associated with obesity, however, the consequences of early life obesity for ED in young adulthood are unknown. We hypothesize that induced by preweaning overfeeding impairs vascular and erectile function affects blood pressure adult male rats (5-month-old). Methods: At postnatal day (PND) 1, Wistar were divided into a normal litter (NL, 5 female + pups/dam) or small (SL, 2 1 pup/dam) during lactation. After weaning, SL pups had increased body...
Introduction: Piezo1, a mechanosensitive nonselective cation channel, is expressed in endothelial and vascular smooth muscle cells. It plays critical role sensing shear stress, generating nitric oxide (NO), regulating tone, promoting angiogenesis, controlling blood pressure. Yoda1, tool compound for has limitations due to its low potency poor water solubility. To overcome these limitations, Yoda1 analogue, Yoda2, was developed. Yoda2 features 4-benzoic acid moiety replacing the pyrazine of...
Introduction: It is well known that lipid mediators secreted by brown adipose tissue (BAT) during cold exposure or beta-adrenergic stimulation can exert beneficial effects on glucose and lipoprotein homeostasis. Recently, Leiria et al. demonstrated one of these mediators, 12-hydroxyeicosapentaenoic acid (12-HEPE), BAT, enhances tolerance insulin sensitivity through the a G protein-coupled receptor (GPCR). However, 12(S)-HEPE binds to its functions was unknown. Therefore, this study aimed...
Obesity is a worldwide public health problem and its treatment includes limited dietary intake of saturated fats physical activity. may be accompanied by metabolic changes cause several organic dysfunctions such as vascular due to reduced bioavailability vasodilatory substances nitric oxide (NO). There are evidences that the related increased reactive oxygen species (ROS), which leads an oxidative stress. Additionally, antioxidant flavonoids has been largely proposed therapy for...
Hyperaldosteronism (HA), characterized by an autonomous production of aldosterone, promotes increased blood pressure and cardiovascular damage. The perivascular adipose tissue (PVAT) participates the control vascular function is inflamed in HA. Autophagy a recycling process unnecessary or dysfunctional components it important for inflammatory tolerance, but whether autophagic flux dysregulated PVAT during HA, which would contribute to inflammation dysfunction this tissue, still be...
Background: Ulcerative Colitis (UC) is a chronic inflammatory disease affecting the colon. Its acute form can be life-threatening, necessitating hospital admission and intravenous (IV) corticosteroid treatment. This study aimed to predict IV response in UC patients based on endoscopic findings at admission. Methods: Individuals admitted for treatment were selected. Those with gastrointestinal infections those without endoscopy excluded. Results: A retrospective analysis was conducted cohort...
Heart failure (HF) is a major public health issue, with an increasing prevalence in the world. Studies have shown strong association of HF development low urinary tract symptoms (LUTS), where approximately 34% men and 62% women reported having LUTS. Moreover, 57% these patients present overactive bladder syndrome. Dysfunction autonomic nervous system alterations important signaling pathways such as nitric oxide/cyclic guanosine monophosphate pathway (NO‐GCs‐GMPc) are HF. Therefore, drugs...
Hesperidin has been used to manage venous disease and shown have vasodilator, antiinflammatory antioxidant properties. The aim of this work was evaluate the efects acute treatment with hesperidin (HD) on vascular reactivity rats in onset arterial hypertension induced by L-NAME. Male Wistar were divided into 3 groups as follow: 1- Control (CTL); 2- L-NAME (LN); 3- + (LNHD). LN given gavage at dose 75mg/Kg, concomitantly HD 0.5 mmol/Kg, 24 hours previously sacrifice. After sacrifice, blood...