A5044451789- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Phagocytosis and Immune Regulation
- Dermatological and COVID-19 studies
- Inflammasome and immune disorders
- Herpesvirus Infections and Treatments
- Natural Compounds in Disease Treatment
- Respiratory viral infections research
- Immune responses and vaccinations
- Retinal and Optic Conditions
- Vector-Borne Animal Diseases
- Dental Research and COVID-19
- Antimicrobial Peptides and Activities
- Vector-borne infectious diseases
- Infection Control and Ventilation
- COVID-19 Impact on Reproduction
- Rabies epidemiology and control
- SARS-CoV-2 detection and testing
- Poverty, Education, and Child Welfare
- Computational Drug Discovery Methods
- Bee Products Chemical Analysis
- Pancreatic function and diabetes
- Streptococcal Infections and Treatments
- Ocular Diseases and Behçet’s Syndrome
Universidade de São Paulo
2020-2024
Avanti (United Kingdom)
2023
Ministry of Science, Technology and Innovation
2023
Universidade Federal de São Paulo
2023
Universidade Federal do Ceará
2023
Secretaria da Saúde
2023
Universidade de Ribeirão Preto
2020-2022
Suma Indústria e Comércio (Brasil)
2021
San Antonio College
2021
Clinics Hospital of Ribeirão Preto
2020
Although SARS-CoV-2 severe infection is associated with a hyperinflammatory state, lymphopenia an immunological hallmark, and correlates poor prognosis in COVID-19. However, it remains unknown if circulating human lymphocytes monocytes are susceptible to infection. In this study, of peripheral blood mononuclear cells (PBMCs) was investigated both vitro vivo . We found that whole PBMCs from healthy donors productive virus progeny. Results revealed monocytes, as well B T lymphocytes, active...
COVID-19 is a disease of dysfunctional immune responses, but the mechanisms triggering immunopathogenesis are not established. The functional plasticity macrophages allows this cell type to promote pathogen elimination and inflammation or suppress tissue remodeling injury repair. During an infection, clearance dead dying cells, process named efferocytosis, can modulate interplay between these contrasting functions. Here, we show that engulfment SARS-CoV-2-infected apoptotic cells exacerbates...
Abstract The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with a hyperinflammatory state and lymphocytopenia, hallmark that appears as both signature prognosis of disease severity outcome. Although cytokine storm sustained inflammatory are commonly immune cell depletion, it still unclear whether direct SARS-CoV-2 cells could also play role in this scenario by harboring viral replication. We found monocytes, well B T lymphocytes, were susceptible to...
Occurrence of hyperglycemia upon infection is associated with worse clinical outcome in COVID-19 patients. However, it still unknown whether SARS-CoV-2 directly triggers hyperglycemia. Herein, we interrogated and how causes by infecting hepatocytes increasing glucose production. We performed a retrospective cohort study including patients that were admitted at hospital suspicion COVID-19. Clinical laboratory data collected from the chart records daily blood values analyzed to test hypothesis...
The rapid spread of SARS-CoV-2 caused a global pandemic. Due to the lack treatment and vaccines, safety strategies must be found stop virus dissemination. objective this study was evaluate virucidal activity ozonated water, powerful oxidizing agent, against SARS-CoV-2. A special faucet source water at low concentration (0.2–0.8 ppm). At concentration, tests with SARS-Cov-2 in Vero CCL81 lineage showed two log10 reduction infectivity upon 1 min exposure comparison controls. It shows potential...
ABSTRACT In the present study, we show that SARS-CoV-2 can infect palatine tonsils, adenoids, and secretions in children without symptoms of COVID-19, with no history recent upper airway infection. We studied 48 undergoing tonsillectomy due to snoring/OSA or recurrent tonsillitis between October 2020 September 2021. Nasal cytobrushes, nasal washes, tonsillar tissue fragments obtained at surgery were tested by RT-qPCR, immunohistochemistry (IHC), flow cytometry, neutralization assay. detected...
The global emergence of coronavirus disease 2019 (COVID-19) has caused substantial human casualties. Clinical manifestations this vary from asymptomatic to lethal, and the symptomatic form can be associated with cytokine storm hyperinflammation. In face urgent demand for effective drugs treat COVID-19, we have searched candidate compounds using in silico approach followed by experimental validation. Here identified celastrol, a pentacyclic triterpene isolated Tripterygium wilfordii Hook F,...
ABSTRACT In the present study, we show that SARS-CoV-2 can infect palatine tonsils and adenoids in children without symptoms of COVID-19, with no history recent upper airway infection. We studied 48 undergoing tonsillectomy due to snoring/OSA or recurrent tonsillitis between October 2020 September 2021. Briefly, nasal cytobrush (NC), wash (NW) tonsillar tissue fragments obtained at surgery were tested by RT-PCR, immunohistochemistry (IHC), flow cytometry neutralization assay. detected...
Abstract COVID-19 is a disease of dysfunctional immune responses, but the mechanisms triggering immunopathogenesis are not established. The functional plasticity macrophages allows this cell type to promote pathogen elimination and inflammation or suppress tissue remodeling injury repair. During an infection, clearance dead dying cells, process named efferocytosis, can modulate interplay between these contrasting functions. Here, we show that engulfment SARS-CoV2-infected apoptotic cells...
A cinomose canina é uma enfermidade infectocontagiosa causada por um RNA vírus do gênero Morbillivirus. De relevância mundial considerada como a segunda principal causa de morte entre os cães dentre as doenças infecciosas, perdendo apenas para raiva. Com alta capacidade imunossupressora o leva à doença neurológica e sistêmica graves. Acomete principalmente não vacinados ou submetidos vacinas com doses incompletas, colostro materno título baixo anticorpos sem título, imunossupressão histórico...
ABSTRACT The world is enduring the SARS CoV-2 pandemic, and although extensive research has been conducted on issue, only a few antivirals have approved to treat patients with COVID-19. Bromhexine hydrochloride was previously identified as potent inhibitor of TMPRSS2, an essential protease for ACE-2 virus receptor interactions. In present study, we investigated whether bromhexine treatment could reduce replication in vitro. To evaluate bromhexine’s effectiveness against COV-2 infection,...
Abstract The global emergence of Covid-19 has caused huge human casualties. Clinical manifestations the disease vary from asymptomatic to lethal, and symptomatic form can be associated with cytokine storm non-homeostatic inflammatory response. In face urgent demand for effective drugs treat Covid-19, we have searched candidate compounds using a drug repurposing approach based on in silico analysis followed by biological validation. Here identified celastrol, pentacyclic triterpene isolated...
Canine monocytic ehrlichiosis is an infectious disease of zoonotic character with worldwide distribution, transmitted by ticks the species Rhipicephalus sanguineus that carry Ehrlichia canis, bacterium responsible for disease. The has three phases: acute, subclinical and chronic, whose approach accurate diagnosis depend directly on Diagnostic techniques are based direct blood analysis, molecular biology also presence of. This study was carried out a comparative analysis diagnostic efficacy...
Treatment options for mild to moderate COVID-19 is limited. N-acetylcysteine and bromhexine have antiviral activity show potential as treatment against SARS-CoV-2 infections. This study evaluates the in vitro effect of (BMX) determines efficacy with BMX combination (NAC) reduce clinical scores patients COVID-19. Upon evidence from pre-clinical studies, a single center randomized trial + NAC (ClinicalTrials.gov Identifier: NCT04928495) 420 participants total took place Fortaleza, CE, Brazil....
Although the COVID-19 pandemic has increased prevalence of cases with olfactory loss, other respiratory viruses can also cause this condition. We aimed to compare acute SARS-CoV-2 infection and in patients sudden smell assess impact viral load co-infection on symptoms.
Treatment options for mild to moderate COVID-19 is limited. N-acetylcysteine and bromhexine have antiviral activity show potential as treatment against SARS-CoV-2 infections. This study evaluates the in vitro effect of (BMX) determines efficacy with BMX combination (NAC) reduce clinical scores patients COVID-19. Upon evidence from preclinical studies, a single center randomized trial + NAC (ClinicalTrials.gov Identifier: NCT04928495) 420 participants total took place Fortaleza, CE, Brazil....
A acupuntura é um dos métodos mais antigos da Medicina Tradicional Chinesa (MTC) que consiste na técnica de estímulo cutâneo com agulhas em locais pré-determinados (os acupontos), para prevenir ou tratar doenças, sendo usada imunomodulação, onde atua atividade hemodinâmica, aumentando a população e das células Natural Killers, CD4+, CD8+, dentre outras. Por este motivo, vem utilizada como terapia complementar no tratamento algumas doenças infecciosas, cinomose canina uma infecciosas...